ES427457A1 - Procedure for the preparation of 2-carbalcoxy-amino-benzymidazol-5 (6) -fenileteres. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 2-carbalcoxy-amino-benzymidazol-5 (6) -fenileteres. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES427457A1
ES427457A1 ES427457A ES427457A ES427457A1 ES 427457 A1 ES427457 A1 ES 427457A1 ES 427457 A ES427457 A ES 427457A ES 427457 A ES427457 A ES 427457A ES 427457 A1 ES427457 A1 ES 427457A1
Authority
ES
Spain
Prior art keywords
carbon atoms
preparation
formula
fenileteres
benzymidazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES427457A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of ES427457A1 publication Critical patent/ES427457A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C07D235/32—Benzimidazole-2-carbamic acids, unsubstituted or substituted; Esters thereof; Thio-analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Preparation of novel 2-carbalkoxyamino-5(6)-benzimidazole phenyl ethers of the formula I < IMAGE > in which R1 denotes alkyl having 1 to 4 carbon atoms, phenyl or p-nitrophenyl R2 and R3, in each case independently of one another, denote hydrogen, hydroxyl, alkoxy having 1 to 4 carbon atoms, halogen, trifluoromethyl, alkyl having 1 to 4 carbon atoms or carbalkoxy having 1 to 4 carbon atoms in the alkoxy radical R4 denotes hydrogen or chlorine and X denotes oxygen or sulphur. The compounds of the formula I are useful chemotherapeutics and are suitable for the control of parasitic disorders in humans and animals. They are particularly active against a large number of helminths, their activity being particularly pronounced against gastrointestinal strongylidae. The compounds of the formula I are prepared by reacting appropriately substituted 2-aminobenzimidazoles with carbonic acid esters.
ES427457A 1973-06-26 1974-06-20 Procedure for the preparation of 2-carbalcoxy-amino-benzymidazol-5 (6) -fenileteres. (Machine-translation by Google Translate, not legally binding) Expired ES427457A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2332487A DE2332487A1 (en) 1973-06-26 1973-06-26 2-CARBALCOXY-AMINO-BENZIMIDAZOL-5 (6) PHENYL ETHER, THEIR PRODUCTION AND USE IN AGENTS AGAINST HELMETS

Publications (1)

Publication Number Publication Date
ES427457A1 true ES427457A1 (en) 1976-07-16

Family

ID=5885126

Family Applications (1)

Application Number Title Priority Date Filing Date
ES427457A Expired ES427457A1 (en) 1973-06-26 1974-06-20 Procedure for the preparation of 2-carbalcoxy-amino-benzymidazol-5 (6) -fenileteres. (Machine-translation by Google Translate, not legally binding)

Country Status (11)

Country Link
JP (1) JPS5753792B2 (en)
AT (1) AT342044B (en)
CH (1) CH608005A5 (en)
DE (1) DE2332487A1 (en)
DK (1) DK341774A (en)
ES (1) ES427457A1 (en)
HU (1) HU168403B (en)
IT (1) IT1056738B (en)
NL (1) NL7408393A (en)
SE (1) SE7408323L (en)
YU (1) YU37149B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9900752D0 (en) * 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents

Also Published As

Publication number Publication date
CH608005A5 (en) 1978-12-15
SE7408323L (en) 1974-12-27
DK341774A (en) 1975-03-17
HU168403B (en) 1976-04-28
YU37149B (en) 1984-08-31
AT342044B (en) 1978-03-10
DE2332487A1 (en) 1975-01-16
YU178274A (en) 1982-06-18
JPS5040566A (en) 1975-04-14
ATA525574A (en) 1977-07-15
NL7408393A (en) 1974-12-30
JPS5753792B2 (en) 1982-11-15
IT1056738B (en) 1982-02-20

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19880208