ES425791A1 - Procedure for the preparation of new amino-phenyl-etanolamines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of new amino-phenyl-etanolamines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES425791A1
ES425791A1 ES425791A ES425791A ES425791A1 ES 425791 A1 ES425791 A1 ES 425791A1 ES 425791 A ES425791 A ES 425791A ES 425791 A ES425791 A ES 425791A ES 425791 A1 ES425791 A1 ES 425791A1
Authority
ES
Spain
Prior art keywords
general formula
compound
group
transformed
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES425791A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2261914A external-priority patent/DE2261914C3/en
Priority claimed from DE19732345442 external-priority patent/DE2345442C2/en
Priority claimed from DE19732351281 external-priority patent/DE2351281C3/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES425791A1 publication Critical patent/ES425791A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the preparation of new amino-phenyl-ethanolamines of the general formula I ** (See formula) ** where R1 signifies a chlorine, bromine or iodine atom; R2 signifies a fluorine atom, a straight chain or branched alcohol group with 1 to 5 carbon atoms, a hydroxyalkyl, aminoalcohyl, dialkoylamino-alcohol, trifluoromethyl, alkoxy, nitro, cyano, carboxy, carbalkoxy or carbamoyl group; R3 and R4, which may be the same or different, mean hydrogen atoms, straight-chain or branched alcohol groups with 1 to 6 carbon atoms, hydroxyalkyl groups, cycloalkyl, cycloalkyl alkoxy or optionally substituted aralkyl groups, as well as their optically active antipodes and of its acid addition salts with physiologically compatible organic or inorganic acids, characterized in that a compound of the general formula II is subjected to halogenation, ** (See formula) ** wherein R2 through R4, are as initially defined; and a compound of the general formula I, obtained according to the procedure, in which R2 represents a cyano group, is then transformed, if desired, by means of hydrolysis, into the corresponding compound of the general formula I, in which R2 represents a carbamoyl or carboxyl group, and/or a compound obtained from the general formula I, in which R2 represents a carbamoyl or carbalkoxy group, is transformed if desired into the corresponding compound of the general formula I, where R2 means a carboxyl group, by hydrolysis, and/or a compound obtained from the general formula I is optionally split into its optically active antipodes and/or a compound of the general formula I, in which R3 or R4 represents an atom Hydrogen is transformed if desired by reaction with an aldehyde of the general formula IV R5 - CHO (IV) wherein R5 signifies a hydrogen atom or a straight or branched chain alcohol group, in an oxazolidine of the general formula Ia ** (See formula) ** wherein R1, R2 and R3 as well as R5 are as initially defined, and/or if desired is transformed into an acid addition salt with a physiologically compatible organic or inorganic acid. (Machine-translation by Google Translate, not legally binding)
ES425791A 1972-12-18 1974-04-30 Procedure for the preparation of new amino-phenyl-etanolamines. (Machine-translation by Google Translate, not legally binding) Expired ES425791A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2261914A DE2261914C3 (en) 1972-12-18 1972-12-18 Amino-phenyl-ethanolamines and their acid addition salts, processes for their production and pharmaceuticals
DE19732345442 DE2345442C2 (en) 1973-09-08 1973-09-08 d- and l-phenylethanolamines and their salts, manufacturing processes and drugs based on them
DE19732351281 DE2351281C3 (en) 1973-10-12 1973-10-12 Aminophenylethanolamine derivatives, their production and use

Publications (1)

Publication Number Publication Date
ES425791A1 true ES425791A1 (en) 1976-06-16

Family

ID=27184904

Family Applications (4)

Application Number Title Priority Date Filing Date
ES421350A Expired ES421350A1 (en) 1972-12-18 1973-12-11 Procedure for the preparation of new amino-phenyl-etanolamines. (Machine-translation by Google Translate, not legally binding)
ES425793A Expired ES425793A1 (en) 1972-12-18 1974-04-30 Procedure for the preparation of new amino-phenyl-etanolamines. (Machine-translation by Google Translate, not legally binding)
ES425791A Expired ES425791A1 (en) 1972-12-18 1974-04-30 Procedure for the preparation of new amino-phenyl-etanolamines. (Machine-translation by Google Translate, not legally binding)
ES425792A Expired ES425792A1 (en) 1972-12-18 1974-04-30 Procedure for the preparation of new amino-phenyl-etanolamines. (Machine-translation by Google Translate, not legally binding)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES421350A Expired ES421350A1 (en) 1972-12-18 1973-12-11 Procedure for the preparation of new amino-phenyl-etanolamines. (Machine-translation by Google Translate, not legally binding)
ES425793A Expired ES425793A1 (en) 1972-12-18 1974-04-30 Procedure for the preparation of new amino-phenyl-etanolamines. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES425792A Expired ES425792A1 (en) 1972-12-18 1974-04-30 Procedure for the preparation of new amino-phenyl-etanolamines. (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
AT (1) AT333251B (en)
CH (2) CH605623A5 (en)
ES (4) ES421350A1 (en)
PH (2) PH20591A (en)
PL (3) PL96538B1 (en)

Also Published As

Publication number Publication date
PL96221B1 (en) 1977-12-31
AT333251B (en) 1976-11-10
CH605656A5 (en) 1978-10-13
PH19317A (en) 1986-03-18
PL96535B1 (en) 1977-12-31
PH20591A (en) 1987-02-20
ATA1028573A (en) 1976-03-15
ES425792A1 (en) 1976-06-16
CH605623A5 (en) 1978-10-13
ES425793A1 (en) 1977-07-01
ES421350A1 (en) 1976-12-01
PL96538B1 (en) 1977-12-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19930125