ES425350A1 - Amines and process for their manufacture - Google Patents

Abstract

Procedure for obtaining new amines of formula Ia **(See formula)** where A means a 1- or 2- [9,10-ethane (or ethene) -antrilic] residue, especially of formula Ib **(See formula)** where Ph signifies an o-phenylene moiety, optionally substituted, Z means an ethylene or ethenylene moiety, optionally with lower alkyl, R3 means lower alkyl moieties, lower alkoxy moieties, hydroxyl groups, nitro groups, amino groups, trifluoromethyl, cyano groups or halogen atoms, or above all it means hydrogen, and n represents the numbers 1, 2 or 3, R1 represents hydrogen or lower alkyl, and R2 represents hydrogen, lower alkyl, arylalkyl lower or carboxyalkyl, in case given functionally modified or R1 and R2 together represent a hydrocarbon moiety of aliphatic character that, if necessary, can be interrupted by heteroatoms and/or substituted, characterized in that a) a compound AO-CH2-CH (X1) -CH2-Z1 (IV) is reacted with a compound Z2-Rxx (V), where one of the residues Z1 and Z2, represents the radical -NH-Rx and the another means an esterified hydroxy group, capable of reaction, one of the residues Rx and Rxx means R1 and the other R2, with A, R1 and R2 having the meaning of above and X1 meaning hydroxy, or where Z1 together with X1 forms an epoxy group and where Z2 signifies -NH-Rx, where Rx signifies R1 or R2, or b) a compound A-OH (VI) is reacted with a compound Z3-CH2-CH (X1) -CH2-N (R1) (R2) (VII), where A, R1 and R2 have the meanings above, means an esterified hydroxyl group, capable of reaction and X1 is hydroxy, or Z3 and X1 together form an epoxy group, or c) in a compound of formula Ia, where A, R1 and R2 have the meanings above and that in the nitrogen atom of the amino group and/or in the hydroxyl group it carries a dissociable residue, this (these) residue (s) dissociate (n), or d) a Schiff base AO-CH2-CH (OH) -CH = N-R2 (IX) or AO-CH2-CH (OH) -CH2-N = R'2 (X) or a corresponding ring tautomer to formula X of formula Xa **(See formula)** where A and R2 have the meaning of above and R'2H is equal to R2 and where compounds of formulas X and Xa can also be presented side by side, it is reduced and, if desired, within the scope of the definition Substituents are introduced, modified or dissociated from the final products, and/or the obtained racemate mixtures are separated into the pure racemates, and/or the obtained racemates are separated into the optical antipodes, and/or the obtained salts are transformed into the free compound or the free compounds obtained in their salts. (Machine-translation by Google Translate, not legally binding)