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ENDO LAB
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A method of preparing octahydroindolobenzazepines, of the formula: **(See formula)** where the hydrogens at positions 4a and 14a are in trans relation to each other; n is 0 or 1; X is an anion of a pharmaceutically suitable acid and Ra is benzyl; benzyl substituted on the ring with methyl, methoxy or chlorine; phenethyl; 3-phenylpropyl; 3-phenylpropyl ring substituted with chlorine, bromine or methoxy; furfuryl; 2-tenyl; cyclopropyl alkyl; C4-C8 alkylmethyl ring; (methylcyclopropyl) methyl; exo-7-norkarylmethyl; (4-methylbicyclo [2.2,2] oct-1-yl) methyl; (bicyclo [2.2.1] hept-1-yl) methyl; 1-adamantylmethyl; or 2-adamantylmethyl; whose method consists in reducing with a boron hydride/tetrahydrofuran complex a compound of the formula: where R2 is the same as Ra or is methoxymethyl, (see formula), where R7 is phenyl; chlorophenyl; methylpheilot methoxyphenyl, benzyl; phenethyl; ring-substituted phenethyl with chlorine; bromine or methoxy; 2-furyl; 2-thienyl; hydrogen; C1-C4 alkyl; C2-C4 alkenyl; styryl; styryl substituted on the ring with chlorine, bromine or methoxy; C3-C7 cycloalkyl methylcyclopropyl; C5-C7-cycloalkenyl-C5-C7-cycloalcadienyl 2,3-dimethylcycloprop-2-en-1-yl; exo-7-norkaryl; 4-methylbicyclo [.2.2] oct-1-yl; bicyclo [2.2.1] hept-2-yl; 4-methylbicyclo [.2.2.2] oct-2-en-1-yl; bicyclo [2.2.2] hept-2-en-5yl; 1-adamantyl; or 2-adamnnthyl; optionally, formylate, alkylate, acylate and reduce sequentially, or hydrogenate the corresponding obtained compounds to transform Ra radicals into other Ra radicals also included within the general definition, and then, optionally, to convert the free base into a salt by reaction with a pharmaceutically suitable acid. (Machine-translation by Google Translate, not legally binding)
ES422528A1973-01-221974-01-22A method of preparation of octahydroindolobenzacepinas. (Machine-translation by Google Translate, not legally binding)
ExpiredES422528A1
(en)
A procedure for preparing N-tienyl alcohil - beta - alcoxitrifluoro-metifenol-cohilaminas. (Machine-translation by Google Translate, not legally binding)
Method of preparation of endomythenic analogue 1,2-dimetilexahidropirilazinas of the same and pharmaceutically acceptable adhesive salts (Machine-translation by Google Translate, not legally binding)