ES421598A1 - Pharmaceutical composition - Google Patents

Pharmaceutical composition

Info

Publication number
ES421598A1
ES421598A1 ES421598A ES421598A ES421598A1 ES 421598 A1 ES421598 A1 ES 421598A1 ES 421598 A ES421598 A ES 421598A ES 421598 A ES421598 A ES 421598A ES 421598 A1 ES421598 A1 ES 421598A1
Authority
ES
Spain
Prior art keywords
formula
temperature
halogenated compound
pharmaceutical composition
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES421598A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AFFILIATED MED RES
Original Assignee
AFFILIATED MED RES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US00315836A external-priority patent/US3839346A/en
Application filed by AFFILIATED MED RES filed Critical AFFILIATED MED RES
Publication of ES421598A1 publication Critical patent/ES421598A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A procedure for the synthesis of pyridones of the formula ** (See formula) ** wherein A is an aromatic group R3, R4, R5 and R6 are individually, each hydrogen, alkyl, aryl or substituted aryl, characterized in that it comprises the steps of reacting a pyridone of the formula ** (See formula) ** where R3, R4, R5 and R6 are as disclosed above, with a halogenated compound of the formula AX, where X is either chlorine, bromine or iodine, at a temperature that varies between temperature melting point and boiling temperature of the halogenated compound, in the presence of an alkali metal carbonate and finely divided metal copper. (Machine-translation by Google Translate, not legally binding)
ES421598A 1972-12-18 1973-12-18 Pharmaceutical composition Expired ES421598A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US00315836A US3839346A (en) 1972-12-18 1972-12-18 N-substituted pyridone and general method for preparing pyridones
US38065573A 1973-07-19 1973-07-19

Publications (1)

Publication Number Publication Date
ES421598A1 true ES421598A1 (en) 1977-01-01

Family

ID=26980095

Family Applications (1)

Application Number Title Priority Date Filing Date
ES421598A Expired ES421598A1 (en) 1972-12-18 1973-12-18 Pharmaceutical composition

Country Status (6)

Country Link
JP (1) JPS4987677A (en)
DE (2) DE2366349C2 (en)
ES (1) ES421598A1 (en)
FR (1) FR2232316B1 (en)
GB (2) GB1458049A (en)
NL (1) NL7317316A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1049411A (en) * 1972-12-18 1979-02-27 Affiliated Medical Research N-substituted pyridone and general method for preparing pyridones
JPS5350179A (en) * 1976-10-15 1978-05-08 Rikagaku Kenkyusho Novel 2-pyridone compounds and their preparation
JP4542743B2 (en) * 2002-12-26 2010-09-15 Ｋｄｌ株式会社 Solution pharmaceutical composition of pyridone derivatives
DK1928454T3 (en) * 2005-05-10 2014-11-03 Intermune Inc PYRIDONE DERIVATIVES FOR MODULATING STRESS-ACTIVATED PROTEINKINATION SYSTEM
MX2007009796A (en) 2007-08-14 2009-02-25 Cell Therapy And Technology S Gel containing pirfenidone.
EP2296653B1 (en) 2008-06-03 2016-01-27 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
AU2012212269B2 (en) * 2011-01-31 2016-05-19 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
MX2011007675A (en) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Process for manufacturing a pharmaceutical composition in a sustained-release tablet form containing pirfenidone and the application thereof in the regression of chronic renal failure, breast capsular contracture and liver fibrosis in humans.
MX346763B (en) 2012-03-28 2017-03-31 Cell Therapy And Tech S A De C V Semi-solid topical composition which contains pirfenidone and modified diallyl disulphide oxide (m-ddo) for eliminating or preventing acne.
AR092742A1 (en) 2012-10-02 2015-04-29 Intermune Inc ANTIFIBROTIC PYRIDINONES
RU2692485C2 (en) 2014-04-02 2019-06-25 Интермьюн, Инк. Antifibrous pyridinones
ITUB20154832A1 (en) 2015-10-29 2017-04-29 Procos Spa PROCESS FOR SYNTHESIS OF PYRPHENING
CA3108048A1 (en) * 2017-07-31 2019-02-07 Washington University Pirfenidone derivatives for modulation of b lymphocyte activity and organ protection

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2947755A (en) * 1959-02-05 1960-08-02 Wallace & Tiernan Inc Substituted 1-m-aminophenyl-2-pyridones
US3655897A (en) * 1971-01-25 1972-04-11 Merck & Co Inc Anti-inflammatory agents

Also Published As

Publication number Publication date
GB1458048A (en) 1976-12-08
DE2362958C2 (en) 1984-06-14
DE2362958A1 (en) 1974-06-27
JPS4987677A (en) 1974-08-22
FR2232316A1 (en) 1975-01-03
FR2232316B1 (en) 1978-03-24
NL7317316A (en) 1974-06-20
GB1458049A (en) 1976-12-08
AU6374673A (en) 1975-06-19
DE2366349C2 (en) 1986-03-27

Similar Documents

Publication Publication Date Title
ES421598A1 (en) Pharmaceutical composition
ES278066A1 (en) Method of preparation of a compound corresponding to the formula (Machine-translation by Google Translate, not legally binding)
ES375199A1 (en) Substituted-1,2,3,4-tetrahydrobenzothieno 2,3-pyridine
ES399003A1 (en) 2-aryl-amino-imidazoline-2 compounds
ES384991A1 (en) Production of adiponitrile
ES449777A1 (en) Substituted pyrimido-quinoline derivatives and pharmaceutical compositions containing them
ES454502A1 (en) Preparation of 1*22benzothiadinee33carboxyamide
ES302251A1 (en) A procedure for the production of 2,1-benzoisotiazoles. (Machine-translation by Google Translate, not legally binding)
ES418666A1 (en) (2-(2-methyl-5-nitro-1-imidazolyl)ethyl)heteroaryloxy ethers
ES417337A2 (en) Derivatives of phenylaminopyridine
ES458198A1 (en) Process for preparing n-chlorophthalimide
ES408746A1 (en) Process for the preparation of 2-/2-aminobenzoyl/ pyridines
ES401239A1 (en) Procedure for the obtaining of heterociclic compounds. (Machine-translation by Google Translate, not legally binding)
ES447185A1 (en) Process for the production of iminopyrrolinones
ES434842A1 (en) Procedure for the preparation of esters of the oxima of erythromycin. (Machine-translation by Google Translate, not legally binding)
ES462774A1 (en) Procedure for the obtaining of new ftalil derivatives of sulfamides. (Machine-translation by Google Translate, not legally binding)
ES454469A1 (en) 7-methoxy cephalosporin derivative
ES440711A1 (en) Process for the production of beta-2-p-chlorophenoxy-isobutyryloxy -ethyl nicotinate
ES327383A1 (en) A procedure for the preparation of antibacterial agents. (Machine-translation by Google Translate, not legally binding)
ES376120A1 (en) Procedure for the preparation of eteres derived from cycleheptanol. (Machine-translation by Google Translate, not legally binding)
ES429319A1 (en) Pyridine derivatives
ES281030A1 (en) Procedure for the preparation of new derivatives of the cumarina (Machine-translation by Google Translate, not legally binding)
ES285739A1 (en) A procedure for the manufacture of heterocyclic compounds (Machine-translation by Google Translate, not legally binding)
ES332176A1 (en) Procedure for the preparation of antibacterial agents (Machine-translation by Google Translate, not legally binding)
ES388250A1 (en) A procedure for preparing pirazolo-piridincarboxilico acid compounds. (Machine-translation by Google Translate, not legally binding)