ES419660A1 - Isoquinolinium compounds - Google Patents

Isoquinolinium compounds

Info

Publication number
ES419660A1
ES419660A1 ES419660A ES419660A ES419660A1 ES 419660 A1 ES419660 A1 ES 419660A1 ES 419660 A ES419660 A ES 419660A ES 419660 A ES419660 A ES 419660A ES 419660 A1 ES419660 A1 ES 419660A1
Authority
ES
Spain
Prior art keywords
formula
group
aryl
groups
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES419660A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Publication of ES419660A1 publication Critical patent/ES419660A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

A procedure for the preparation of new isoquinoline derivatives of general formula I **(See formula)** where R1 and R5, which may be the same or different, represent an alkyl, alkenyl or alkynyl group, the groups of which may optionally be substituted with amino, alkylamino or dialkylamino groups or with hydroxy, (C1-4) alkoxy, aroyl, aryl or aryloxy groups., where the aroyl, aryl or aryloxy groups may contain a (C1-4) alkoxy substituent; and R5 may further represent a cycloalkyl group containing from 4 to 8 carbon atoms or a heterocyclic group; R2 and R3, which may be the same or different, represent a hydrogen atom or an alkyl group; R4 represents a hydrogen atom or an alkyl group, which in turn can be substituted with an aryl or aryloxy group, whose aryl or aryloxy group can also be substituted with a (C1-4) alkoxy substituent; or R4 may represent an aryl group which may be substituted with a (C1-4) alkoxy substituent; and X represents a pharmaceutically acceptable anion of an organic or inorganic acid; with the proviso that R1 is not methyl when R2 and R3 are hydrogen, R4 is hydrogen or benzyl, R5O is methoxy and X-represents an iodide or perchlorate radical; the procedure of which is to react, in any desired order, a compound of the formula: **(See formula)** with a compound of formula R1X to form the quaternary derivative and react the latter with a compound of formula R5X to form the desired ether of formula I (where R1, R2, R3, R4, R5 and X have the meaning given above) and then, if desired, react the compound obtained to effect the conversion of any of R1-R5 and X into other groups within the meanings given. (Machine-translation by Google Translate, not legally binding)
ES419660A 1972-10-19 1973-10-15 Isoquinolinium compounds Expired ES419660A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4821172A GB1407685A (en) 1972-10-19 1972-10-19 Isoquinolinium compounds

Publications (1)

Publication Number Publication Date
ES419660A1 true ES419660A1 (en) 1976-07-01

Family

ID=10447780

Family Applications (1)

Application Number Title Priority Date Filing Date
ES419660A Expired ES419660A1 (en) 1972-10-19 1973-10-15 Isoquinolinium compounds

Country Status (15)

Country Link
JP (1) JPS49132081A (en)
AT (1) AT333283B (en)
BE (1) BE806131A (en)
CA (1) CA1019743A (en)
CH (1) CH598224A5 (en)
DE (1) DE2351184A1 (en)
DK (1) DK134013B (en)
ES (1) ES419660A1 (en)
FR (1) FR2203629B1 (en)
GB (1) GB1407685A (en)
IE (1) IE38339B1 (en)
LU (1) LU68628A1 (en)
NL (1) NL7314378A (en)
SE (1) SE402286B (en)
ZA (1) ZA737712B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067529B2 (en) * 2003-05-19 2006-06-27 Hoffmann-La Roche Inc. Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors
BRPI0415497A (en) * 2003-10-16 2006-12-26 Hoffmann La Roche process compound for its preparation, pharmaceutical composition comprising the same, use of a compound and method for treating type II diabetes
FR3135816A1 (en) 2022-05-20 2023-11-24 Elno Militarized electrical connector intended to be connected to audio equipment, associated connection cable and audio system

Also Published As

Publication number Publication date
FR2203629A1 (en) 1974-05-17
SE402286B (en) 1978-06-26
FR2203629B1 (en) 1976-07-02
NL7314378A (en) 1974-04-23
LU68628A1 (en) 1973-12-27
AU6123573A (en) 1975-04-10
IE38339L (en) 1974-04-19
JPS49132081A (en) 1974-12-18
DE2351184A1 (en) 1974-05-02
ZA737712B (en) 1974-08-28
GB1407685A (en) 1975-09-24
IE38339B1 (en) 1978-02-15
CA1019743A (en) 1977-10-25
ATA878373A (en) 1976-03-15
DK134013C (en) 1977-01-31
AT333283B (en) 1976-11-10
CH598224A5 (en) 1978-04-28
BE806131A (en) 1974-04-16
DK134013B (en) 1976-08-30

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