ES419660A1 - Isoquinolinium compounds - Google Patents
Isoquinolinium compoundsInfo
- Publication number
- ES419660A1 ES419660A1 ES419660A ES419660A ES419660A1 ES 419660 A1 ES419660 A1 ES 419660A1 ES 419660 A ES419660 A ES 419660A ES 419660 A ES419660 A ES 419660A ES 419660 A1 ES419660 A1 ES 419660A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- group
- aryl
- groups
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/10—Quaternary compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
A procedure for the preparation of new isoquinoline derivatives of general formula I **(See formula)** where R1 and R5, which may be the same or different, represent an alkyl, alkenyl or alkynyl group, the groups of which may optionally be substituted with amino, alkylamino or dialkylamino groups or with hydroxy, (C1-4) alkoxy, aroyl, aryl or aryloxy groups., where the aroyl, aryl or aryloxy groups may contain a (C1-4) alkoxy substituent; and R5 may further represent a cycloalkyl group containing from 4 to 8 carbon atoms or a heterocyclic group; R2 and R3, which may be the same or different, represent a hydrogen atom or an alkyl group; R4 represents a hydrogen atom or an alkyl group, which in turn can be substituted with an aryl or aryloxy group, whose aryl or aryloxy group can also be substituted with a (C1-4) alkoxy substituent; or R4 may represent an aryl group which may be substituted with a (C1-4) alkoxy substituent; and X represents a pharmaceutically acceptable anion of an organic or inorganic acid; with the proviso that R1 is not methyl when R2 and R3 are hydrogen, R4 is hydrogen or benzyl, R5O is methoxy and X-represents an iodide or perchlorate radical; the procedure of which is to react, in any desired order, a compound of the formula: **(See formula)** with a compound of formula R1X to form the quaternary derivative and react the latter with a compound of formula R5X to form the desired ether of formula I (where R1, R2, R3, R4, R5 and X have the meaning given above) and then, if desired, react the compound obtained to effect the conversion of any of R1-R5 and X into other groups within the meanings given. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB4821172A GB1407685A (en) | 1972-10-19 | 1972-10-19 | Isoquinolinium compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES419660A1 true ES419660A1 (en) | 1976-07-01 |
Family
ID=10447780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES419660A Expired ES419660A1 (en) | 1972-10-19 | 1973-10-15 | Isoquinolinium compounds |
Country Status (15)
Country | Link |
---|---|
JP (1) | JPS49132081A (en) |
AT (1) | AT333283B (en) |
BE (1) | BE806131A (en) |
CA (1) | CA1019743A (en) |
CH (1) | CH598224A5 (en) |
DE (1) | DE2351184A1 (en) |
DK (1) | DK134013B (en) |
ES (1) | ES419660A1 (en) |
FR (1) | FR2203629B1 (en) |
GB (1) | GB1407685A (en) |
IE (1) | IE38339B1 (en) |
LU (1) | LU68628A1 (en) |
NL (1) | NL7314378A (en) |
SE (1) | SE402286B (en) |
ZA (1) | ZA737712B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7067529B2 (en) * | 2003-05-19 | 2006-06-27 | Hoffmann-La Roche Inc. | Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors |
BRPI0415497A (en) * | 2003-10-16 | 2006-12-26 | Hoffmann La Roche | process compound for its preparation, pharmaceutical composition comprising the same, use of a compound and method for treating type II diabetes |
FR3135816A1 (en) | 2022-05-20 | 2023-11-24 | Elno | Militarized electrical connector intended to be connected to audio equipment, associated connection cable and audio system |
-
1972
- 1972-10-19 GB GB4821172A patent/GB1407685A/en not_active Expired
-
1973
- 1973-10-01 IE IE1747/73A patent/IE38339B1/en unknown
- 1973-10-02 ZA ZA737712A patent/ZA737712B/en unknown
- 1973-10-11 DE DE19732351184 patent/DE2351184A1/en active Pending
- 1973-10-15 ES ES419660A patent/ES419660A1/en not_active Expired
- 1973-10-16 CA CA183,479A patent/CA1019743A/en not_active Expired
- 1973-10-16 AT AT878373A patent/AT333283B/en not_active IP Right Cessation
- 1973-10-16 BE BE136736A patent/BE806131A/en unknown
- 1973-10-16 LU LU68628A patent/LU68628A1/xx unknown
- 1973-10-18 JP JP48117362A patent/JPS49132081A/ja active Pending
- 1973-10-18 FR FR7337198A patent/FR2203629B1/fr not_active Expired
- 1973-10-18 DK DK564673AA patent/DK134013B/en unknown
- 1973-10-18 SE SE7314205A patent/SE402286B/en unknown
- 1973-10-18 NL NL7314378A patent/NL7314378A/xx not_active Application Discontinuation
- 1973-10-18 CH CH1472273A patent/CH598224A5/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FR2203629A1 (en) | 1974-05-17 |
SE402286B (en) | 1978-06-26 |
FR2203629B1 (en) | 1976-07-02 |
NL7314378A (en) | 1974-04-23 |
LU68628A1 (en) | 1973-12-27 |
AU6123573A (en) | 1975-04-10 |
IE38339L (en) | 1974-04-19 |
JPS49132081A (en) | 1974-12-18 |
DE2351184A1 (en) | 1974-05-02 |
ZA737712B (en) | 1974-08-28 |
GB1407685A (en) | 1975-09-24 |
IE38339B1 (en) | 1978-02-15 |
CA1019743A (en) | 1977-10-25 |
ATA878373A (en) | 1976-03-15 |
DK134013C (en) | 1977-01-31 |
AT333283B (en) | 1976-11-10 |
CH598224A5 (en) | 1978-04-28 |
BE806131A (en) | 1974-04-16 |
DK134013B (en) | 1976-08-30 |
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