ES419093A3 - Procedure for preparing quinoxalin - 2 - carboxamide - 1,4 - bioxides replaced in position 3. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for preparing quinoxalin-2-carboxamide-1,4-dioxides substituted in position 3, of the formula **(See formula)** where X is a substituent at the 6 or 7 position and is hydrogen, methyl, methoxy, chlorine, fluorine, bromine or trifluoromethyl; Y is lower alkylthio; R is hydrogen or lower alkyl; R2 is hydrogen, lower alkyl or substituted lower alkyl where the substituent is (a) amino, mono (lower alkyl) amino, di (lower alkyl) amino, pyrrolidino, piperidino, morpholino, N- (lower alkyl) piperazino, N- hydroxy (lower alkyl) piperazino, N- (lower alkalyl) piperazino, N-carbon (lower alkoxy) piperazino, pyrrolo, piperazino, imidazolidino, (b) hydroxy, lower alkoxy, carboxy, carbo (lower) alkoxy, carbamyl, mono (lower alkyl) carbamyl, di (lower alkyl) carbamyl, lower alkanoyloxy, lower alkanoylamino; and R1 and R2 when taken together with the nitrogen to which they are fixed are pyrrolo, pyrrolidino, piperidino, morpholino, thiomorpholino, piperazino, N- (lower alkyl) piperazino, N-hydroxy (lower alkyl) piperazino, N- (alkanoyl lower) piperazino and N-carbo (lower alkoxy) piperazino; and the pharmaceutically acceptable acid addition salts of those compounds where R2 is substituted lower alkyl where the substituent is from group (a), characterized by reacting a compound of the formula **(See formula)** with a mercaptan of the formula HY wherein X, R1, R2, and Y are as defined above, in the presence of an alkali metal hydroxide selected from the group comprising sodium hydroxide and potassium hydroxide. (Machine-translation by Google Translate, not legally binding)