ES418443A1 - Process for the obtaining of N- (2-n'ciclohexil n'-methyl-n'metilen) -4,6-dibromo-phenyl) -3-metoxy-4-acetoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) - Google Patents

Process for the obtaining of N- (2-n'ciclohexil n'-methyl-n'metilen) -4,6-dibromo-phenyl) -3-metoxy-4-acetoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES418443A1
ES418443A1 ES73418443A ES418443A ES418443A1 ES 418443 A1 ES418443 A1 ES 418443A1 ES 73418443 A ES73418443 A ES 73418443A ES 418443 A ES418443 A ES 418443A ES 418443 A1 ES418443 A1 ES 418443A1
Authority
ES
Spain
Prior art keywords
metoxy
acetoxy
metilen
ciclohexil
dibromo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES73418443A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Noucor Health SA
Original Assignee
J Uriach y Cia SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J Uriach y Cia SA filed Critical J Uriach y Cia SA
Priority to ES73418443A priority Critical patent/ES418443A1/en
Priority to BE147567A priority patent/BE818800A/en
Priority to GB3650274A priority patent/GB1432904A/en
Priority to FR7428846A priority patent/FR2259595B1/fr
Priority to DE2440596A priority patent/DE2440596C3/en
Priority to CH1154474A priority patent/CH584679A5/en
Publication of ES418443A1 publication Critical patent/ES418443A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Process for the obtaining of N- [2- (n '' - ciclohexil-n "- methyl-n''metilen) -4,6-dibromofenil] -3-metoxy-4-acetoxy-benzamide hydrochloride. The 3,5-dibromo-N-cyclohexil-N-methyltoluen-2-diamine, or any of its inorganic acid salts with the 3-metoxy-4-acetoxy-benzoic acid chloride in the sine of an inert solvent is reactioned. By evaporation of the solvent, in vacuum at temperature not exceeding 50 degrees c, the desired product is obtained, which is recrilled in absolute ethical alcohol. (Machine-translation by Google Translate, not legally binding)
ES73418443A 1973-08-24 1973-08-24 Process for the obtaining of N- (2-n'ciclohexil n'-methyl-n'metilen) -4,6-dibromo-phenyl) -3-metoxy-4-acetoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding) Expired ES418443A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES73418443A ES418443A1 (en) 1973-08-24 1973-08-24 Process for the obtaining of N- (2-n'ciclohexil n'-methyl-n'metilen) -4,6-dibromo-phenyl) -3-metoxy-4-acetoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)
BE147567A BE818800A (en) 1973-08-24 1974-08-13 NEW COMPOUNDS FOR USE AS MUCOLYTIC AGENTS AND THEIR PREPARATION
GB3650274A GB1432904A (en) 1973-08-24 1974-08-20 N-2-n-cyclohexyl-n-methylaminomethyl-4,6-dibromo-phenyl-benzamides methods for their preparation and compositions containing them
FR7428846A FR2259595B1 (en) 1973-08-24 1974-08-22
DE2440596A DE2440596C3 (en) 1973-08-24 1974-08-23 N-P-N'-CyclohexyW'-Meftyl-N'-methylenAe, dibromophenyl -3-alkoxy-4-acyloxy-benzamide hydrochloride derivatives, their preparation and use
CH1154474A CH584679A5 (en) 1973-08-24 1974-08-23 Mucolytic ortho-benzamido-N-methyl-N-cyclohexyl-benzylamine derivs. - N-(2-(N'-methyl-cyclohexylamino-methyl)-4,6-dibromophenyl)-3-alko- xy-4-acyloxy)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES73418443A ES418443A1 (en) 1973-08-24 1973-08-24 Process for the obtaining of N- (2-n'ciclohexil n'-methyl-n'metilen) -4,6-dibromo-phenyl) -3-metoxy-4-acetoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
ES418443A1 true ES418443A1 (en) 1976-03-16

Family

ID=8464945

Family Applications (1)

Application Number Title Priority Date Filing Date
ES73418443A Expired ES418443A1 (en) 1973-08-24 1973-08-24 Process for the obtaining of N- (2-n'ciclohexil n'-methyl-n'metilen) -4,6-dibromo-phenyl) -3-metoxy-4-acetoxy-benzamide, hydrochloride. (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
BE (1) BE818800A (en)
CH (1) CH584679A5 (en)
ES (1) ES418443A1 (en)

Also Published As

Publication number Publication date
BE818800A (en) 1974-12-02
CH584679A5 (en) 1977-02-15

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