ES409942A1 - Procedure for the preparation of an N-arilmidate compound. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A procedure for the preparation of an N-arylimidate compound of the general formula I **(See formula)** and its pharmaceutically acceptable acid addition salts, in which formula **(See formula)** R1 represents lower alkyl, lower cycloalkyl, aralkyl or aryl, X represents nitro, trifluoromethyl or halogen, Y represents hydrogen, halogen, nitro, lower alkyl, lower alkoxy, lower alkanoyl, polyfluoroalkoxy, polyfluoroalkyl or trifluoromethylthio, A represents (see formula), wherein R2 and R3 independently represent Z-substituted alkyl in which the alkyl moiety is straight-chain or branched and has at most 5 carbon atoms, or R2 and R3, together with the Carbon atoms to which they are attached represent cycloalkyl: Z-substituted wherein the cycloalkyl moiety has 5 carbon atoms at most, and Z represents hydrogen, halogen, or an etherified or esterified free hydroxy group, except that when X and Y are both chlorine, or when X is chlorine and Y is methyl, then R1 is lower alkyl, lower cycloalkyl, or aralkyl, characterized by subjecting an N-arylimidohaline of the general formula II to alcohololysis **(See formula)** by reaction with a hydroxy compound of the general formula III **(See formula)** or with a salt thereof, in which formula X, Y, A and R1 have the meaning indicated above and Z is hydrogen, halogen or an etherified hydroxyl group and isolate the compound thus obtained from the general formula I in free form or in the form of a pharmaceutically acceptable acid addition salt of yours. (Machine-translation by Google Translate, not legally binding)