ES405442A1 - Procedure for the preparation of 4,4-diaril-piperidines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 4,4-diaril-piperidines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES405442A1
ES405442A1 ES405442A ES405442A ES405442A1 ES 405442 A1 ES405442 A1 ES 405442A1 ES 405442 A ES405442 A ES 405442A ES 405442 A ES405442 A ES 405442A ES 405442 A1 ES405442 A1 ES 405442A1
Authority
ES
Spain
Prior art keywords
compound
group
carbon atoms
formula
case
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES405442A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19712139084 external-priority patent/DE2139084C3/en
Priority claimed from DE19712139085 external-priority patent/DE2139085C3/en
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of ES405442A1 publication Critical patent/ES405442A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Procedure for the preparation of 4,4-diaryl-piperidines of the general formula II as well as their acid addition salts **(See formula)** in which R1 means a hydrogen atom, a straight chain or branched alcoholic group with 1 to 6 carbon atoms, an optionally halogenated aralcohyl group or spun aleo, where the alcohol chain has 1 to 3 carbon atoms, or a hydroxyalkyl, alkoxyalkyl or aryloxyalkyl group with 1 to 3 carbon atoms in the alcohol chain in each case, or an aryloxoalcohyl group with 1 to 3 carbon atoms in the possibly halogenated, alkoxylated or alkoxylated alcoholic group in the benzene ring, and the radicals R2 signify a hydrogen atom or equal halogen atoms in the energetically preferred position in each case, especially in the para position, characterized in that benzene (in the case in which R2 = hydrogen) or a halogenobenzene (in the case in than R2 = halogen) in the presence of a Friedel-Crafts catalyst, with a compound of general formulas III or IV **(See formula)** where R1 has the foregoing meanings and R3 means a hydrogen or halogen atom and, when desired, in the case of the preparation of compounds in which R1 is a hydrogen atom, of a compound of formula II in that R1 signifies a benzyl group, which has been obtained according to the above procedure, the benzyl group is removed by hydrogenation or transformed into an alkoxycarbonyl group, preferably with 2 to 7 carbon atoms and the latter is saponified and decarboxylated, and/or, when desired, a compound of formula II obtained, in which R1 signifies a hydrogen atom, is transformed in a manner known per se, by reaction with a compound R1-X wherein X signifies a functional group capable to react, such as a halogen atom, or by reaction with an unsaturated compound by reaction by addition with a nitrogen atom, in a compound of formula II in which R1 has the above meanings except hydrogen, and/or, c When desired, a free compound obtained is transformed into an acid addition salt or a salt obtained is transformed into the free compound. (Machine-translation by Google Translate, not legally binding)
ES405442A 1971-08-04 1972-08-02 Procedure for the preparation of 4,4-diaril-piperidines. (Machine-translation by Google Translate, not legally binding) Expired ES405442A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19712139084 DE2139084C3 (en) 1971-08-04 1971-08-04 Process for the preparation of 4,4-diphenyl-piperidines
DE19712139085 DE2139085C3 (en) 1971-08-04 1971-08-04 Halogenated 4,4-diphenyl-piperidines, processes for their preparation and pharmaceuticals containing them

Publications (1)

Publication Number Publication Date
ES405442A1 true ES405442A1 (en) 1975-07-01

Family

ID=25761540

Family Applications (1)

Application Number Title Priority Date Filing Date
ES405442A Expired ES405442A1 (en) 1971-08-04 1972-08-02 Procedure for the preparation of 4,4-diaril-piperidines. (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
JP (1) JPS599552B2 (en)
AT (2) AT321918B (en)
CH (2) CH575927A5 (en)
ES (1) ES405442A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56127932U (en) * 1980-02-22 1981-09-29
JPS614463U (en) * 1984-06-15 1986-01-11 富士通テン株式会社 hybrid integrated circuit

Also Published As

Publication number Publication date
JPS599552B2 (en) 1984-03-03
AT324340B (en) 1975-08-25
CH585201A5 (en) 1977-02-28
CH575927A5 (en) 1976-05-31
JPS4826769A (en) 1973-04-09
AT321918B (en) 1975-04-25

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