ES404592A1 - Procedimiento para la preparacion de 2,3-dihidro-oxo-imida-zo (1,2-a) - pirimidinas. - Google Patents
Procedimiento para la preparacion de 2,3-dihidro-oxo-imida-zo (1,2-a) - pirimidinas.Info
- Publication number
- ES404592A1 ES404592A1 ES404592A ES404592A ES404592A1 ES 404592 A1 ES404592 A1 ES 404592A1 ES 404592 A ES404592 A ES 404592A ES 404592 A ES404592 A ES 404592A ES 404592 A1 ES404592 A1 ES 404592A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- see formula
- salts
- group
- bromine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- JCNIHTFDQRYQDU-UHFFFAOYSA-N 3h-imidazo[1,2-a]pyrimidin-2-one Chemical class C1=CC=NC2=NC(=O)CN21 JCNIHTFDQRYQDU-UHFFFAOYSA-N 0.000 title 1
- 150000003254 radicals Chemical class 0.000 abstract 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
- 229910052794 bromium Inorganic materials 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- -1 piperidino, piperazino, morpholino Chemical group 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical group [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2133998A DE2133998A1 (de) | 1971-07-08 | 1971-07-08 | 2,3-dihydro-oxo-imidazo eckige klammer auf 1,2-a eckige klammer zu -pyrimidine, deren saeureadditionssalze und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES404592A1 true ES404592A1 (es) | 1975-06-16 |
Family
ID=5813032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES404592A Expired ES404592A1 (es) | 1971-07-08 | 1972-07-06 | Procedimiento para la preparacion de 2,3-dihidro-oxo-imida-zo (1,2-a) - pirimidinas. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3816422A (en:Method) |
| AU (1) | AU468994B2 (en:Method) |
| BE (1) | BE786028A (en:Method) |
| CH (1) | CH583235A5 (en:Method) |
| DE (1) | DE2133998A1 (en:Method) |
| ES (1) | ES404592A1 (en:Method) |
| FR (1) | FR2144875B1 (en:Method) |
| GB (1) | GB1391803A (en:Method) |
| NL (1) | NL7209481A (en:Method) |
| NO (1) | NO135752C (en:Method) |
| SE (1) | SE396388B (en:Method) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1442483A (en) * | 1974-03-27 | 1976-07-14 | Ici Ltd | Imidazo-1,2-a- pyrimidine derivatives |
| CH638215A5 (de) * | 1977-02-04 | 1983-09-15 | Hoffmann La Roche | Oxadiazolopyrimidin-derivate. |
| CH638216A5 (de) * | 1977-02-04 | 1983-09-15 | Hoffmann La Roche | Oxadiazolopyrimidin-deriate. |
| DE3124718A1 (de) | 1981-06-24 | 1983-01-13 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue imidazo (1,2-a)pyramidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
| CA1211111A (en) * | 1982-02-15 | 1986-09-09 | Isao Yanagisawa | Process for preparing novel pyrimidone compounds |
| BR9803368A (pt) | 1997-09-05 | 2001-04-24 | Sumitomo Chemical Co | Derivados de perimidona e herbecidas contendo os mesmos |
| EP0947516A1 (en) * | 1998-03-30 | 1999-10-06 | Sumitomo Chemical Company, Limited | N-benzyl substituted, heterocyclic ring-fused pyrimidinone derivatives, their preparation and their use as herbicides |
| CN101762657B (zh) * | 2009-12-18 | 2012-08-22 | 武汉武药科技有限公司 | 盐酸美哌隆的高效液相色谱分析方法 |
| HRP20221389T1 (hr) | 2013-10-18 | 2023-01-06 | Celgene Quanticel Research, Inc. | Inhibitori bromodomena |
| WO2015153468A1 (en) * | 2014-03-31 | 2015-10-08 | The Scripps Research Institute | Pharmacophore for trail induction |
| AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
| AU2017252276A1 (en) | 2016-04-18 | 2018-11-15 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
-
0
- BE BE786028D patent/BE786028A/xx unknown
-
1971
- 1971-07-08 DE DE2133998A patent/DE2133998A1/de active Pending
-
1972
- 1972-06-30 US US00268215A patent/US3816422A/en not_active Expired - Lifetime
- 1972-07-06 ES ES404592A patent/ES404592A1/es not_active Expired
- 1972-07-07 NO NO2447/72A patent/NO135752C/no unknown
- 1972-07-07 CH CH1023972A patent/CH583235A5/xx not_active IP Right Cessation
- 1972-07-07 NL NL7209481A patent/NL7209481A/xx unknown
- 1972-07-07 SE SE7209052A patent/SE396388B/xx unknown
- 1972-07-07 AU AU44368/72A patent/AU468994B2/en not_active Expired
- 1972-07-07 FR FR7224710A patent/FR2144875B1/fr not_active Expired
- 1972-07-07 GB GB3200572A patent/GB1391803A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2144875B1 (en:Method) | 1976-03-05 |
| NL7209481A (en:Method) | 1973-01-10 |
| GB1391803A (en) | 1975-04-23 |
| BE786028A (fr) | 1973-01-08 |
| SE396388B (sv) | 1977-09-19 |
| CH583235A5 (en:Method) | 1976-12-31 |
| AU468994B2 (en) | 1976-01-29 |
| US3816422A (en) | 1974-06-11 |
| AU4436872A (en) | 1974-01-10 |
| DE2133998A1 (de) | 1973-01-25 |
| FR2144875A1 (en:Method) | 1973-02-16 |
| NO135752B (en:Method) | 1977-02-14 |
| NO135752C (en:Method) | 1977-05-25 |
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