ES400862A1 - Procedimiento para redisolver isomeros opticos. - Google Patents
Procedimiento para redisolver isomeros opticos.Info
- Publication number
- ES400862A1 ES400862A1 ES400862A ES400862A ES400862A1 ES 400862 A1 ES400862 A1 ES 400862A1 ES 400862 A ES400862 A ES 400862A ES 400862 A ES400862 A ES 400862A ES 400862 A1 ES400862 A1 ES 400862A1
- Authority
- ES
- Spain
- Prior art keywords
- base
- salt
- optical isomers
- acid
- produce
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003287 optical effect Effects 0.000 title abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Braiding, Manufacturing Of Bobbin-Net Or Lace, And Manufacturing Of Nets By Knotting (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT49167/71A IT951631B (it) | 1971-03-18 | 1971-03-18 | Composti utili per la separazione di isomeri ottici geometrici e strutturali e relativo procedimen to di sintesi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES400862A1 true ES400862A1 (es) | 1976-04-16 |
Family
ID=11269830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES400862A Expired ES400862A1 (es) | 1971-03-18 | 1972-03-17 | Procedimiento para redisolver isomeros opticos. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3848030A (Direct) |
| JP (1) | JPS5547013B1 (Direct) |
| AU (1) | AU462431B2 (Direct) |
| BE (1) | BE780887A (Direct) |
| CA (1) | CA961500A (Direct) |
| CH (1) | CH576921A5 (Direct) |
| DE (1) | DE2212660C3 (Direct) |
| DK (1) | DK139944B (Direct) |
| ES (1) | ES400862A1 (Direct) |
| FR (1) | FR2129741A5 (Direct) |
| GB (1) | GB1360946A (Direct) |
| IL (1) | IL38860A (Direct) |
| IT (1) | IT951631B (Direct) |
| NL (1) | NL7203574A (Direct) |
| NO (1) | NO136357C (Direct) |
| PH (1) | PH10768A (Direct) |
| SE (1) | SE409323B (Direct) |
| ZA (1) | ZA721297B (Direct) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4143028A (en) * | 1977-12-05 | 1979-03-06 | Ciba-Geigy Corporation | Alkylated 1,1'-biphenyl-2,2'-diyl phosphonites and stabilized compositions |
| US5288914A (en) * | 1984-08-27 | 1994-02-22 | The Dow Chemical Company | Poly(arylcyclobutenes) |
| NL8403224A (nl) * | 1984-10-24 | 1986-05-16 | Oce Andeno Bv | Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen. |
| DE3940765A1 (de) * | 1989-12-09 | 1991-06-13 | Hoechst Ag | Verfahren zur herstellung reiner cyclischer phosphorsaeurediarylester |
| JPH10503752A (ja) * | 1994-05-16 | 1998-04-07 | メリル・フアーマシユウテイカルズ・インコーポレイテツド | ラセミ形α−〔４−（１，１−ジメチルエチル）フェニル〕−４−（ヒドロキシジフェニルメチル）−１−ピペリジンブタノールおよび誘導体化合物の光学分割に有用な方法およびジアステレオマー塩 |
| JP4725757B2 (ja) * | 1999-03-24 | 2011-07-13 | 東ソー株式会社 | ビナフトールリン酸誘導体及びその利用 |
| US6274745B1 (en) | 1999-03-24 | 2001-08-14 | Tosoh Corporation | Binaphthol monophosphoric acid derivative and its use |
| ATE320420T1 (de) | 1999-10-22 | 2006-04-15 | Takeda Pharmaceutical | Verfahren zur herstellung von optisch aktiven naphthalinderivaten und darin eingesetzte optische resolver |
| WO2001034557A1 (en) * | 1999-11-10 | 2001-05-17 | Takeda Chemical Industries, Ltd. | Process for the production of optically active cyclic enaminone derivatives |
| US6391926B2 (en) | 2000-03-13 | 2002-05-21 | Tosoh Corporation | Optically active phosphate derivative |
| WO2003005954A2 (en) | 2001-07-09 | 2003-01-23 | Zonagen, Inc. | Methods and materials for the treatment of testosterone deficiency in men |
| CN100410234C (zh) * | 2003-04-25 | 2008-08-13 | 东亚合成株式会社 | 利用手性布朗斯台德酸的不对称合成用催化剂和使用该催化剂的不对称合成方法 |
| US7229557B2 (en) * | 2004-02-04 | 2007-06-12 | Konec, Inc. | Method to separate stereoisomers |
| EP2486032A4 (en) * | 2009-10-09 | 2013-03-27 | Hetero Research Foundation | RACEMATSPALTUNG SUBSTITUTED 2- (2-PYRIDINYLMETHYLSULFINYL) -1H-BENZIMIDAZOLE |
| UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
| US20150202167A1 (en) | 2012-08-21 | 2015-07-23 | Repros Therapeutics Inc. | Trans-Clomiphene Formulations and Uses Thereof |
| CN104994877A (zh) | 2012-11-02 | 2015-10-21 | 利普生物药剂公司 | 用于癌症治疗的反式-克罗米芬 |
| WO2015138340A1 (en) * | 2014-03-11 | 2015-09-17 | Repros Therapeutics Inc. | Clomiphene synthesis using a single solvent |
| RU2020120156A (ru) | 2014-07-24 | 2020-07-03 | Эспен Парк Фармасьютикалз, Инк. | Лечение приливов и потери костной ткани, вызванных андрогенной депривационной терапией с применением цис-кломифена |
| EP3015453B1 (en) | 2014-10-28 | 2016-10-12 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Process for the preparation of Clomiphene |
| EP3015454A1 (en) * | 2014-10-28 | 2016-05-04 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Stable solid form of trans-Clomiphene citrate |
| WO2017182097A1 (en) | 2016-04-22 | 2017-10-26 | F.I.S. - Fabbrica Italiana Sintetici S.P.A. | Process for the preparation of enclomiphene citrate having needle shaped crystal habit. |
| EP3681491A4 (en) | 2017-09-11 | 2021-06-30 | Atossa Therapeutics, Inc. | Methods for making and using endoxifen |
| FR3082842A1 (fr) * | 2018-06-21 | 2019-12-27 | Veru Inc. | Polymorphe de cis-clomiphene (zuclomiphene) et procedes d'utilisation de celui-ci |
| US12201591B2 (en) | 2019-07-03 | 2025-01-21 | Atossa Therapeutics, Inc. | Sustained release compositions of endoxifen |
| CA3098725A1 (en) | 2019-11-14 | 2021-05-14 | Apotex Inc. | Zuclpomiphene salts and crystalline forms thereof |
| CA3098552A1 (en) | 2019-11-14 | 2021-05-14 | Apotex Inc. | Processes for the preparation of zuclomiphene and intermediates thereof |
| CA3105944A1 (en) | 2020-01-22 | 2021-07-22 | Apotex Inc. | Crystalline forms of zuclomiphene citrate |
| EP3907213A1 (en) | 2020-05-04 | 2021-11-10 | Pcas | Processes for the production of isomerically pure or enriched cis-clomiphene |
| US11578025B2 (en) | 2020-10-19 | 2023-02-14 | Apotex Inc. | Processes for the preparation of zuclomiphene intermediates |
-
1971
- 1971-03-18 IT IT49167/71A patent/IT951631B/it active
-
1972
- 1972-02-28 ZA ZA721297A patent/ZA721297B/xx unknown
- 1972-02-29 IL IL38860A patent/IL38860A/xx unknown
- 1972-03-03 AU AU39611/72A patent/AU462431B2/en not_active Expired
- 1972-03-03 PH PH13312A patent/PH10768A/en unknown
- 1972-03-09 GB GB1104172A patent/GB1360946A/en not_active Expired
- 1972-03-09 CA CA136,671A patent/CA961500A/en not_active Expired
- 1972-03-10 US US00233793A patent/US3848030A/en not_active Expired - Lifetime
- 1972-03-15 SE SE7203303A patent/SE409323B/xx unknown
- 1972-03-16 DE DE2212660A patent/DE2212660C3/de not_active Expired
- 1972-03-17 JP JP2661472A patent/JPS5547013B1/ja active Pending
- 1972-03-17 BE BE780887A patent/BE780887A/xx unknown
- 1972-03-17 FR FR7209350A patent/FR2129741A5/fr not_active Expired
- 1972-03-17 ES ES400862A patent/ES400862A1/es not_active Expired
- 1972-03-17 CH CH395572A patent/CH576921A5/xx not_active IP Right Cessation
- 1972-03-17 NO NO880/72A patent/NO136357C/no unknown
- 1972-03-17 NL NL7203574A patent/NL7203574A/xx not_active Application Discontinuation
- 1972-03-17 DK DK127372AA patent/DK139944B/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7203574A (Direct) | 1972-09-20 |
| SE409323B (sv) | 1979-08-13 |
| IL38860A0 (en) | 1972-04-27 |
| CH576921A5 (Direct) | 1976-06-30 |
| DE2212660A1 (de) | 1972-09-28 |
| NO136357C (no) | 1977-08-24 |
| FR2129741A5 (Direct) | 1972-10-27 |
| CA961500A (en) | 1975-01-21 |
| ZA721297B (en) | 1973-03-28 |
| DK139944B (da) | 1979-05-21 |
| DE2212660C3 (de) | 1981-09-24 |
| NO136357B (Direct) | 1977-05-16 |
| IL38860A (en) | 1975-06-25 |
| GB1360946A (en) | 1974-07-24 |
| IT951631B (it) | 1973-07-10 |
| DE2212660B2 (de) | 1980-07-10 |
| US3848030A (en) | 1974-11-12 |
| DK139944C (Direct) | 1979-10-22 |
| PH10768A (en) | 1977-09-05 |
| AU462431B2 (en) | 1975-06-09 |
| AU3961172A (en) | 1973-09-06 |
| JPS5547013B1 (Direct) | 1980-11-27 |
| BE780887A (fr) | 1972-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES400862A1 (es) | Procedimiento para redisolver isomeros opticos. | |
| ES306821A1 (es) | Procedimiento para producir un benzotriazol sustituido. | |
| ES392008A1 (es) | Un procedimiento para la preparacion de enantiomeros opti- cos. | |
| GB1261469A (en) | An optical isomer of chrysanthemic acid and processes for preparing it | |
| ES411901A1 (es) | Procedimiento para la preparacion de esteres liquidos cris-talinos. | |
| ES442887A1 (es) | Un procedimiento para la preparacion de un nuevo compuesto d-6-metil-ergolina 8-sustituida. | |
| ES404744A1 (es) | Un procedimiento para producir derivados de cefalosporina. | |
| GB1396368A (en) | Perfluoroalkyl sulphinic acids and a process for their production | |
| ES421098A1 (es) | Un metodo para la preparacion de tiaxantenos fluor-susti- tuidos. | |
| GB863550A (en) | 3-mercapto-phenthiazines | |
| ES417396A1 (es) | Un procedimiento para la produccion de una composicion far-maceutica. | |
| ES402263A1 (es) | Un metodo para sintetizar nuevos analogos de prostaglandi- na. | |
| ES395804A1 (es) | Un procedimiento de preparacion de beta - halocinil - este-res de acidos fosforotianicos. | |
| ATE18208T1 (de) | N-(4-hydroxyphenyl)essigsaeureamid-estern aus 5benzoyl-1-methylpyrrol-2-essigsaeure. | |
| ES325827A1 (es) | Procedimiento para producir compuestos de 2-fenoxi-2-fenilacetamida. | |
| ES421284A1 (es) | Procedimiento para la preparacion de derivados de acidos pirrocolinaceticos. | |
| ES444439A1 (es) | Procedimiento para la obtencion de carbonatos de cetooxima. | |
| ES451091A1 (es) | Procedimiento para la produccion del compuesto s 11743na en forma de acido. | |
| FR2364919A1 (fr) | Procede de chloration d'ergolines | |
| ES453718A1 (es) | Un procedimiento analogico de preparacion de una sal de adi-cion de acido. | |
| ES383884A3 (es) | Procedimiento para la obtencion de esteres y sales de es- teres del cloranfenicol. | |
| ES266945A1 (es) | Procedimiento de obtenciën de derivados de tiaxanteno | |
| ES420471A1 (es) | Un procedimiento para la produccion de derivados sustituidosde acido fenoxi-alfa-metilpropionico. | |
| ES277094A1 (es) | Procedimiento de producción de nuevos derivados del tiaxanteno | |
| ES419656A1 (es) | Un procedimiento para la produccion de un compuesto de un ester alilaminoalcanolico. |