ES400536A1 - Procedure for the preparation of esters of desametazona and betametazona. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of esters of desametazona and betametazona. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES400536A1
ES400536A1 ES400536A ES400536A ES400536A1 ES 400536 A1 ES400536 A1 ES 400536A1 ES 400536 A ES400536 A ES 400536A ES 400536 A ES400536 A ES 400536A ES 400536 A1 ES400536 A1 ES 400536A1
Authority
ES
Spain
Prior art keywords
translation
esters
preparation
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES400536A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of ES400536A1 publication Critical patent/ES400536A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for the preparation of esters of desametazone and betamethasone, of the general formula I **(See formula)** where R represents -CH3 or CH3, R'represents H, CH3, R''represents COCH3; -CO-C6H5, n represents an integer from 1 to 8, characterized by reacting desametazone or betamethasone with an acyl chloride of the general formula **(See formula)** where R', R''and n have the meanings indicated above, in the presence of a proton acceptor and an inert solvent, at a temperature between -10 and + 10ºC. (Machine-translation by Google Translate, not legally binding)
ES400536A 1971-03-17 1972-03-08 Procedure for the preparation of esters of desametazona and betametazona. (Machine-translation by Google Translate, not legally binding) Expired ES400536A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2192871A IT1044212B (en) 1971-03-17 1971-03-17 ESTERS OF BESAMETAZONE AND BETAMETAZONE

Publications (1)

Publication Number Publication Date
ES400536A1 true ES400536A1 (en) 1975-02-01

Family

ID=11188923

Family Applications (1)

Application Number Title Priority Date Filing Date
ES400536A Expired ES400536A1 (en) 1971-03-17 1972-03-08 Procedure for the preparation of esters of desametazona and betametazona. (Machine-translation by Google Translate, not legally binding)

Country Status (6)

Country Link
BE (1) BE780375A (en)
DE (1) DE2211695A1 (en)
ES (1) ES400536A1 (en)
FR (1) FR2130320A1 (en)
IT (1) IT1044212B (en)
NL (1) NL7203262A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1516095A (en) * 1974-07-31 1978-06-28 Glaxo Lab Ltd 17,21-diesters of 17alpha,21-dihydroxy-steroids of the pregnane series
US4456602A (en) * 1982-08-23 1984-06-26 The Upjohn Company Amine containing ester prodrugs of corticosteroids

Also Published As

Publication number Publication date
NL7203262A (en) 1972-09-19
FR2130320A1 (en) 1972-11-03
DE2211695A1 (en) 1972-09-28
IT1044212B (en) 1980-03-20
BE780375A (en) 1972-07-03

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