ES400238A1 - Procedure for the preparation of 1-acil-5-phenyl-1-h 1,5-benzodiazepin-2,4- (3h, 5h) -dionas. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 1-acil-5-phenyl-1-h 1,5-benzodiazepin-2,4- (3h, 5h) -dionas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES400238A1
ES400238A1 ES400238A ES400238A ES400238A1 ES 400238 A1 ES400238 A1 ES 400238A1 ES 400238 A ES400238 A ES 400238A ES 400238 A ES400238 A ES 400238A ES 400238 A1 ES400238 A1 ES 400238A1
Authority
ES
Spain
Prior art keywords
radical
formula
halogen atom
phenyl
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES400238A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES400238A1 publication Critical patent/ES400238A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/16—Nitrogen-containing compounds
    • C08K5/20—Carboxylic acid amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedure for the preparation of 1-acyl-5-phenyl-1H-l, 5-benzodiazepin-2,4- (3H, 5H) -diones of the general formula **(See formula)** where R1 signifies a hydrogen atom; an alcohol radical with 1 to 3 carbon atoms; a halogenomethyl radical; the cyclohexyl radical; a phenyl radical optionally substituted once or twice by a halogen atom, the methyl, methoxy or nitro group; the benzyl radical or the styryl radical; R2 means a hydrogen atom or a halogen atom or a trifluoromethyl or nitro group; y stands for a halogen atom or the trifluoromethyl group, characterized in that a suitably substituted 2-acylamino-diphenyl-amine of the general formula is reacted **(See formula)** in which the radicals R1, R2 and R3 have the meanings indicated above, with a malonic acid halide of the formula **(See formula)** where R signifies a lower alcohol radical and Hal signifies a halogen atom; The malonic acid ester amide obtained from the general formula is saponified in the usual way. **(See formula)** where R1, R2, and R have the meanings mentioned above, and free acid of the general formula is treated with ring-closing agents **(See formula)** in which R1, R2 and R3 have the meanings mentioned above. (Machine-translation by Google Translate, not legally binding)
ES400238A 1971-03-01 1972-02-28 Procedure for the preparation of 1-acil-5-phenyl-1-h 1,5-benzodiazepin-2,4- (3h, 5h) -dionas. (Machine-translation by Google Translate, not legally binding) Expired ES400238A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT174471A AT308755B (en) 1971-03-01 1971-03-01 Process for the preparation of 1-acyl-5-phenyl-1H-1,5-benzodiazepine-2,4- (3H, 5H) -diones

Publications (1)

Publication Number Publication Date
ES400238A1 true ES400238A1 (en) 1975-06-16

Family

ID=3520071

Family Applications (2)

Application Number Title Priority Date Filing Date
ES400238A Expired ES400238A1 (en) 1971-03-01 1972-02-28 Procedure for the preparation of 1-acil-5-phenyl-1-h 1,5-benzodiazepin-2,4- (3h, 5h) -dionas. (Machine-translation by Google Translate, not legally binding)
ES425165A Expired ES425165A1 (en) 1971-03-01 1974-04-09 Procedure for the preparation of 1-acil-5-phenyl-1H-1,5benzodiazepin-2,4- (3h, 5h) -dionas. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES425165A Expired ES425165A1 (en) 1971-03-01 1974-04-09 Procedure for the preparation of 1-acil-5-phenyl-1H-1,5benzodiazepin-2,4- (3h, 5h) -dionas. (Machine-translation by Google Translate, not legally binding)

Country Status (7)

Country Link
AT (1) AT308755B (en)
CA (1) CA992540A (en)
CH (2) CH570384A5 (en)
DK (1) DK137725B (en)
ES (2) ES400238A1 (en)
NL (1) NL7202671A (en)
SE (3) SE389339B (en)

Also Published As

Publication number Publication date
SE389339B (en) 1976-11-01
DK137725B (en) 1978-04-24
AT308755B (en) 1973-07-25
ES425165A1 (en) 1976-07-01
DK137725C (en) 1978-10-02
NL7202671A (en) 1972-09-05
CH570987A5 (en) 1975-12-31
SE393803B (en) 1977-05-23
SE7407780L (en) 1974-06-12
CA992540A (en) 1976-07-06
CH570384A5 (en) 1975-12-15

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