ES392912A1 - Procedure for the preparation of 5 - phenyl - 3h - 1 - substitute benzodiazepines. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 5 - phenyl - 3h - 1 - substitute benzodiazepines. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES392912A1
ES392912A1 ES392912A ES392912A ES392912A1 ES 392912 A1 ES392912 A1 ES 392912A1 ES 392912 A ES392912 A ES 392912A ES 392912 A ES392912 A ES 392912A ES 392912 A1 ES392912 A1 ES 392912A1
Authority
ES
Spain
Prior art keywords
formula
compound
see formula
benzodiazepines
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES392912A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratories Pharmedical SA
Original Assignee
Laboratories Pharmedical SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratories Pharmedical SA filed Critical Laboratories Pharmedical SA
Publication of ES392912A1 publication Critical patent/ES392912A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Procedure for the preparation of substituted 5-phenyl-3H-1,4-benzodiazepines of the general formula: **(See formula)** where R1 is selected from hydrogen, lower alkyl and alkylaryl; R2 and R3 are selected from hydrogen, lower alkyl, methoxy, ethoxy, nitro and halogen; and Y is selected from carbonyl and methylene, characterized by comprising the treatment of phthalic anhydride of the formula: **(See formula)** with an aminated derivative of the formula: HO-y-CH2-NH2 where Y has the meaning indicated above for obtaining a compound of formulas **(See formula)** which is treated with a thionyl halide: X2SO, where X represents a halogen, in hot, obtaining the compound of formula; **(See formula)** where X and Y have the values indicated above, which is heat treated in the presence of an organic solvent with a compound of formula (III) **(See formula)** where R1 and R2 have the values previously expressed and R4 is selected from oxygen, imone and hydrazine to obtain a compound of formula (II): **(See formula)** where R1, R2, R3, R4 and Y have the values mentioned above, and this compound (II) is then treated with an excess of hydrazine hydrate: H2N - NHOH in an organic solvent and hot until cyclization of the diazepine nucleus is achieved. (Machine-translation by Google Translate, not legally binding)
ES392912A 1970-12-21 1971-07-05 Procedure for the preparation of 5 - phenyl - 3h - 1 - substitute benzodiazepines. (Machine-translation by Google Translate, not legally binding) Expired ES392912A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AR23309070 1970-12-21

Publications (1)

Publication Number Publication Date
ES392912A1 true ES392912A1 (en) 1974-07-01

Family

ID=3461858

Family Applications (1)

Application Number Title Priority Date Filing Date
ES392912A Expired ES392912A1 (en) 1970-12-21 1971-07-05 Procedure for the preparation of 5 - phenyl - 3h - 1 - substitute benzodiazepines. (Machine-translation by Google Translate, not legally binding)

Country Status (4)

Country Link
BE (1) BE772825A (en)
CH (1) CH573929A5 (en)
DE (1) DE2159920A1 (en)
ES (1) ES392912A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1087017B (en) * 1977-10-18 1985-05-31 Ravizza Spa PROCESS FOR THE PREPARATION OF A 7-CHLORO-5- (2-CHLOROPHENYL) -BENZODIAZE PINONE
BRPI0901298A2 (en) * 2009-04-06 2011-01-04 Ems Sa phthalimide derivatives of nonsteroidal antiinflammatory compounds and / or modulators of tnf- (alpha), process for obtaining them, pharmaceutical compositions containing them and their uses in the treatment of inflammatory diseases

Also Published As

Publication number Publication date
BE772825A (en) 1972-01-17
CH573929A5 (en) 1976-03-31
DE2159920A1 (en) 1972-06-29

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