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E R A S M E SOC
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Priority to ES379188ApriorityCriticalpatent/ES379188A3/en
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Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms
(AREA)
Plural Heterocyclic Compounds
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
A method of preparing adamantane derivatives of the general formula **(See formula)** where (see formula) can be: - a primary or secondary amine in which R1 and R2 are the same or different and are selected from hydrogen, linear or branched alkyl radicals, saturated or unsaturated, from 1 to 8 carbon atoms; When R1 and R2 are alkyl radicals, they can be linked directly or through an oxygen or nitrogen atom to form heterocyclic amines such as pyrrolidine, piperidine, hexamethyleneimine, morpholine, N-methylpiperazine, 2,2,5,5-tetramethylpyrrolidine, 2, 5-dihydro-2,2,5,5-tetramethylpyrrolidine, 2,2,6,6-tetramethylpiperidine and 1,2,3,6-tetrahydro-2,2,6,6-tetramethylpyridine; - a primary amine containing a cycloalkyl radical of 1 to 7 carbon atoms; and salts of these derivatives with organic or inorganic acids; whose procedure consists of reacting hydroxymethylammantane with epichlorohydrin, in the presence of catalytic amounts of an acid, preferably sulfuric acid; react the product obtained with an alkaline base, preferably potash, in anhydrous medium in order to form the corresponding epoxide derivative and then react this epoxide derivative with a suitable amine of the formula (see formula). (Machine-translation by Google Translate, not legally binding)
ES379188A1970-04-291970-04-29A procedure for the preparation of adamantan derivatives. (Machine-translation by Google Translate, not legally binding)
ExpiredES379188A3
(en)
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