ES377889A2 - A procedure for preparing a purine compound. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Improvements introduced in the object of the main patent No. 370,618 applied for on August 19, 1969 by: "A process for preparing a purine compound" characterized in that the pyrimidine compound of the general formula **(See formula)** where R1 is hydrogen, nitro, nitroso, aryldiazo, amino or acylamino, R2 is hydrogen, hydroxyl, mercapto, lower alkoxy, lower aralkoxy, lower alcoholylthio, amino, hydrinoxyamine, lower alcohol-amino, dialkoyl lower-amino, lower aralkoxy- amino, phenylalkyl-lower-amino or lower-alkoxy-amino, R3 is hydrogen, halogen, hydroxyl, mercapto, amino, lower-alcohol, aryl, lower-alkoxy, lower-aralkoxy or alcoholylthio, R4 is lower-alcohol-substituted with one or more -hydroxyls (but no hydroxyl group being present on the carbon atom adjacent to the nitrogen atom), which may be protected with acyl, lower alcohol, lower aralkohyl or, when there is a pair of hydroxyl in the alcohol group, with lower alcoholidene or lower aralkohylidene and R5 is hydroxyl, lower or higher alkoxy, amino, lower alcohol-amino or dialkoyl lower-amino, is obtained by reacting a compound of formula **(See formula)** wherein X is halogen and R1, R2 and R3 are each as defined above, with a reagent of the formula: H2N-R4-CO-R5 wherein R4 and R5 are each as defined above, optionally followed by reduction of the resulting product, or optionally followed by acylation of the resulting product, if necessary, while reducing. (Machine-translation by Google Translate, not legally binding)