ES375524A1 - A procedure for the preparation of aminocarbonylalkilic compounds N-substituted or n, N-disused. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A process for the preparation of N-substituted or N, N-disubstituted aminocarbonylalkyl compounds of formula: **(See formula)** where Z is sulfur or lower alkylimino, A is lower alkylene, R1 is hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl, R2 is hydrogen, lower alkyl or lower hydroxyalkyl, and R3 is hydrogen, lower alkyl, haloalkyl lower, hydroxyalkyl lower, alkanoyl (lower) oxyalkyl, alkoxy (lower) lower alkyl, hydroxyalkoxy (lower) lower alkyl, hydroxycarbonylalkyl lower, alkoxy (lower) carbonylalkyl lower, phenyl with or without one or more substituents lower alkyl, halogen, hydroxyl, alkoxy lower or lower alkanoyl, lower phenylalkyl with or without substituents on the benzene ring, consisting of one or more lower alkyl, halogen, hydroxyl, lower alkoxy and lower alkanoyl groups, or the group of formula: **(See formula)** where A'is lower alkylene and R4 and R5 are each lower alkyl or phenyl or, when attached to the adjacent nitrogen atom, represent a 5- to 7-membered nitrogen heterocyclic group, or a group of the formula: **(See formula)** represents a 3- to 7-membered heterocyclic group, provided that R1 is not hydrogen when R2 and r3 are each lower alkyl or, in a linked form, represent a lower alkylene group or a lower oxaalkylene group and R1 is not chlorine when R2 and R3 are both hydrogen, the procedure of which is to react a compound of the formulas: **(See formula)** where R is carboxyl or aziridinocarbonyl and Z, A and R1 are each as defined above, their salts or their reactive derivatives, with an amine of formula: **(See formula)** where R2 and R3 are each as defined above, with the proviso that when R is aziridinocarbonyl, R2 is hydrogen and R3 is a group of formula: **(See formula)** where R4 and R5 are those defined above. (Machine-translation by Google Translate, not legally binding)