ES373199A1 - Procedure to produce a prostaglandine compound. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure to produce a prostaglandine compound. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES373199A1 ES373199A1 ES373199A ES373199A ES373199A1 ES 373199 A1 ES373199 A1 ES 373199A1 ES 373199 A ES373199 A ES 373199A ES 373199 A ES373199 A ES 373199A ES 373199 A1 ES373199 A1 ES 373199A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- alkanoyl
- cis
- formul
- trans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000000034 method Methods 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940006138 antiglaucoma drug and miotics prostaglandin analogues Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000133 nasal decongestant Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 abstract 1
- 230000001850 reproductive effect Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Novel prostaglandin analogues of the Formul[mu] I, II and III wherein R 1 is H, C 1-8 alkyl, or a pharmacologically acceptable cation, R 2 and R 3 are H or C 1-8 alkanoyl, with the proviso that when R 3 is alkanoyl R 2 is also alkanoyl, Z is -CH 2 CH 2 -, or cis-CH = CH-, m is 0 or 2, and p is 3 or 5 are prepared by reducing the corresponding compounds of Formul[mu] I, II and III above in which the groups OR 3 are replaced by carbonyl groups, and, if desired, acylating the resulting hydroxy groups, and esterifying or salifying any of the compounds thus obtained in which R 1 is H. Alternatively, compounds of Formula III above may be obtained by reducing the carbon to carbon double bonds in the corresponding compound of the formula in which X is trans -CH = CH- and Y and Z are -CH 2 CH 2 -, or X is trans-CH=CH-, Y is cis-CH=CH- and Z is -CH 2 CH 2 - or cis-CH = CH-. Therapeutic compositions, suitable for topical or parenteral administration, contain the above novel prostanoic acid derivatives together with pharmaceutically acceptable carriers. The compounds have pressor activity and activity on the central nervous system, inhibit gastric secretion, blood platelet aggregation and thrombus formation. They may also be used for inducing labour in pregnant animals, nasal decongestants, controlling the reproductive cycle in ovulating female mammals, and hypotensive agents.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77513168A | 1968-11-12 | 1968-11-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES373199A1 true ES373199A1 (en) | 1972-03-16 |
Family
ID=25103422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES373199A Expired ES373199A1 (en) | 1968-11-12 | 1969-11-05 | Procedure to produce a prostaglandine compound. (Machine-translation by Google Translate, not legally binding) |
Country Status (12)
| Country | Link |
|---|---|
| BE (1) | BE741555A (en) |
| BR (1) | BR6913826D0 (en) |
| CH (2) | CH540215A (en) |
| DE (1) | DE1956290A1 (en) |
| DK (1) | DK134507B (en) |
| ES (1) | ES373199A1 (en) |
| FR (1) | FR2024837B1 (en) |
| GB (1) | GB1251750A (en) |
| IL (1) | IL33226A (en) |
| NL (1) | NL6916822A (en) |
| PL (1) | PL80526B1 (en) |
| SE (1) | SE380015B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA01008955A (en) | 1999-03-05 | 2002-04-24 | Procter & Gamble | C16. |
| US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US20020037914A1 (en) | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US8623918B2 (en) | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3290226A (en) * | 1964-02-19 | 1966-12-06 | Upjohn Co | Microbiological conversion of unsaturated fatty acids |
| US3505386A (en) * | 1965-12-29 | 1970-04-07 | Upjohn Co | Compounds related to prostaglandins |
| GB1198071A (en) * | 1966-08-09 | 1970-07-08 | George Erich Just | Improvements in or relating to Prostaglandin Analogues and the Manufacture thereof |
| US3435053A (en) * | 1966-06-06 | 1969-03-25 | Upjohn Co | Cyclopenta(b)pyrans |
-
1969
- 1969-10-03 GB GB1251750D patent/GB1251750A/en not_active Expired
- 1969-10-21 IL IL33226A patent/IL33226A/en unknown
- 1969-10-27 CH CH1844371A patent/CH540215A/en not_active IP Right Cessation
- 1969-10-27 CH CH1605169A patent/CH517685A/en not_active IP Right Cessation
- 1969-10-31 BR BR213826/69A patent/BR6913826D0/en unknown
- 1969-11-05 ES ES373199A patent/ES373199A1/en not_active Expired
- 1969-11-07 NL NL6916822A patent/NL6916822A/xx unknown
- 1969-11-08 DE DE19691956290 patent/DE1956290A1/en active Pending
- 1969-11-11 PL PL1969136834A patent/PL80526B1/pl unknown
- 1969-11-11 DK DK595469AA patent/DK134507B/en unknown
- 1969-11-11 SE SE6915475A patent/SE380015B/xx unknown
- 1969-11-12 BE BE741555D patent/BE741555A/xx unknown
- 1969-11-12 FR FR696938853A patent/FR2024837B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2024837B1 (en) | 1973-07-13 |
| SE380015B (en) | 1975-10-27 |
| CH540215A (en) | 1973-09-28 |
| GB1251750A (en) | 1971-10-27 |
| DK134507B (en) | 1976-11-22 |
| CH517685A (en) | 1972-01-15 |
| BR6913826D0 (en) | 1973-02-13 |
| DK134507C (en) | 1977-04-18 |
| IL33226A0 (en) | 1969-12-31 |
| IL33226A (en) | 1973-10-25 |
| PL80526B1 (en) | 1975-08-30 |
| FR2024837A1 (en) | 1970-09-04 |
| DE1956290A1 (en) | 1970-06-11 |
| BE741555A (en) | 1970-05-12 |
| NL6916822A (en) | 1970-05-14 |
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