ES371149A1 - Perhydro-5-phenyl-cycloalkapolyene-1,4-oxazepines and their preparations - Google Patents

Perhydro-5-phenyl-cycloalkapolyene-1,4-oxazepines and their preparations

Info

Publication number
ES371149A1
ES371149A1 ES371149A ES371149A ES371149A1 ES 371149 A1 ES371149 A1 ES 371149A1 ES 371149 A ES371149 A ES 371149A ES 371149 A ES371149 A ES 371149A ES 371149 A1 ES371149 A1 ES 371149A1
Authority
ES
Spain
Prior art keywords
compounds
salts
intermediates
alkyl
solvates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES371149A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of ES371149A1 publication Critical patent/ES371149A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Novel, therapeutic and herbicidal compounds I (including cis-A, cis-B, trans-C and trans-D compounds and salts, solvates, N-oxides and salts thereof) where n is 1 to 4, R 1 is H, C 1-16 alkyl, phenalkyl, C 1-16 alkanoyl, benzoyl, phenacetyl, p-(CH 2 ) 3 . CO.C 6 H 4 .F, p-SO 2 .C 6 H 4 .NH 2 , alkyl- or dialkylaminoalkyl, or unsubstituted or mono- or polyalkyl-substituted pyrrolidino-, piperidino-, morpholino-, piperazino-, or hexamethyleneiminoalkyl, R 2 is or O =, R 3 , R 4 and R 5 are H, OH, halogen, C 1-6 alkyl, alkoxy and alkanoyloxy, or CF 3 and R 6 is are obtained by cyclizing compounds III or V and, if desired, reducing oxazepinones obtained (by cyclizing V) to afford the corresponding oxazepine this procedure gives rise to I in which R 1 is H-standard methods are utilized for preparing I in which R 1 is other than H, e.g. alkylation, acetylation and reduction substituents symbolized as R 3 , R 4 and R 5 can, if appropriate, be converted one into the other and I wherein R 1 is -SO 2 .C 6 H 4 .NH 2 is obtained by reducing the corresponding nitro compound. The preparation of certain of the starting materials and intermediates II, III, IV and V is also described and exemplified as well as salts and solvates thereof reaction schemes also utilize processes whereby isomers of these starting materials and intermediates are converted into other isomers. Intermediates corresponding to IV and wherein the NH 2 group is replaced by NH.CH 2 Ph are also described and exemplified as are the compounds corresponding to IV in which the CHOH group is replaced by CO. An electrocardiographic jelly comprises a quaternary ammonium salt of I, glycerol, starch and water.
ES371149A 1968-09-03 1969-09-02 Perhydro-5-phenyl-cycloalkapolyene-1,4-oxazepines and their preparations Expired ES371149A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75713568A 1968-09-03 1968-09-03

Publications (1)

Publication Number Publication Date
ES371149A1 true ES371149A1 (en) 1971-08-16

Family

ID=25046507

Family Applications (1)

Application Number Title Priority Date Filing Date
ES371149A Expired ES371149A1 (en) 1968-09-03 1969-09-02 Perhydro-5-phenyl-cycloalkapolyene-1,4-oxazepines and their preparations

Country Status (13)

Country Link
US (1) US3598808A (en)
BE (1) BE738376A (en)
BR (1) BR6912057D0 (en)
CH (1) CH520156A (en)
DE (1) DE1944468A1 (en)
DK (1) DK134434B (en)
ES (1) ES371149A1 (en)
FR (1) FR2017274B1 (en)
GB (1) GB1232756A (en)
IL (1) IL32827A (en)
NL (1) NL6913402A (en)
PH (1) PH9358A (en)
SE (1) SE364283B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201712A (en) * 1975-07-16 1980-05-06 Boehringer Ingelheim Gmbh Process for preparation of 6-aryl-4H-s-triazolo-[3,4-c]-thieno-[2,3-e]-1,4-diazepines
DE2846567A1 (en) * 1978-10-26 1980-05-08 Basf Ag NEW 1,4-CYCLOALKANOOXAZEPINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
US4435400A (en) 1982-07-19 1984-03-06 Merck & Co., Inc. Amino and alkylaminoalkenoate ester derivatives of aminochloronitropyrazine
US4590187A (en) * 1983-11-17 1986-05-20 The Upjohn Company Phospholipase A2 inhibition using 4,1-benzoxazepine-2-(3H)-ones
US4800200A (en) * 1987-12-21 1989-01-24 Hoechst-Roussel Pharmaceuticals Inc. 4,8-dihydro-8-arylisoxazolo[4,3-e][1,4]-oxazepin-5(6H)-ones
US5123867A (en) * 1990-05-10 1992-06-23 Stefan Broinowski Marine jet propulsion unit

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1090611A (en) * 1963-05-22 1967-11-08 Lepetit Spa 4,1-benzoxazepine derivatives

Also Published As

Publication number Publication date
DK134434B (en) 1976-11-08
PH9358A (en) 1975-10-06
FR2017274B1 (en) 1974-01-11
FR2017274A1 (en) 1970-05-22
DE1944468A1 (en) 1970-03-12
CH520156A (en) 1972-03-15
DK134434C (en) 1977-04-04
GB1232756A (en) 1971-05-19
NL6913402A (en) 1970-03-05
SE364283B (en) 1974-02-18
US3598808A (en) 1971-08-10
BE738376A (en) 1970-03-03
IL32827A (en) 1972-06-28
IL32827A0 (en) 1969-11-12
BR6912057D0 (en) 1973-05-10

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