ES369391A1 - A procedure for the preparation of derivatives of benzodiacepinas. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of derivatives of benzodiacepinas. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES369391A1
ES369391A1 ES369391A ES369391A ES369391A1 ES 369391 A1 ES369391 A1 ES 369391A1 ES 369391 A ES369391 A ES 369391A ES 369391 A ES369391 A ES 369391A ES 369391 A1 ES369391 A1 ES 369391A1
Authority
ES
Spain
Prior art keywords
translation
procedure
preparation
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES369391A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES369391A1 publication Critical patent/ES369391A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

A procedure for the preparation of benzodiazepine derivatives of the general formula **(See formula)** wherein R is hydrogen, halogen, trifluoromethyl, lower alkyl, or lower alkoxy; R1 is lower alkyl; and R2 is hydrogen, halogen, lower alkyl or lower alkoxy, characterized by reacting a compound of the general formula **(See formula)** where R and R1 have the same meaning as before, with an organometallic phenyl compound of the formula **(See formula)** where R2 has the same meaning as before, while A is lithium, MgBr, MgCl and MgI. (Machine-translation by Google Translate, not legally binding)
ES369391A 1968-07-12 1969-07-11 A procedure for the preparation of derivatives of benzodiacepinas. (Machine-translation by Google Translate, not legally binding) Expired ES369391A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74433768A 1968-07-12 1968-07-12

Publications (1)

Publication Number Publication Date
ES369391A1 true ES369391A1 (en) 1971-05-16

Family

ID=24992327

Family Applications (1)

Application Number Title Priority Date Filing Date
ES369391A Expired ES369391A1 (en) 1968-07-12 1969-07-11 A procedure for the preparation of derivatives of benzodiacepinas. (Machine-translation by Google Translate, not legally binding)

Country Status (6)

Country Link
AT (1) AT290539B (en)
BR (1) BR6910557D0 (en)
CH (1) CH511866A (en)
ES (1) ES369391A1 (en)
HU (1) HU162254B (en)
NL (1) NL6910323A (en)

Also Published As

Publication number Publication date
AT290539B (en) 1971-06-11
NL6910323A (en) 1970-01-14
BR6910557D0 (en) 1973-02-15
HU162254B (en) 1973-01-29
CH511866A (en) 1971-08-31

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