ES366470A1 - Un procedimiento para la preparacion de pirazinoilgunidinasy pirazinomidoguanidinas. - Google Patents

Un procedimiento para la preparacion de pirazinoilgunidinasy pirazinomidoguanidinas.

Info

Publication number
ES366470A1
ES366470A1 ES366470A ES366470A ES366470A1 ES 366470 A1 ES366470 A1 ES 366470A1 ES 366470 A ES366470 A ES 366470A ES 366470 A ES366470 A ES 366470A ES 366470 A1 ES366470 A1 ES 366470A1
Authority
ES
Spain
Prior art keywords
alkyl
compound
mononuclear aryl
pirazinomidoguanidinas
pirazinoilgunidinas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES366470A
Other languages
English (en)
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES366470A1 publication Critical patent/ES366470A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
ES366470A 1968-04-30 1969-04-25 Un procedimiento para la preparacion de pirazinoilgunidinasy pirazinomidoguanidinas. Expired ES366470A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72550868A 1968-04-30 1968-04-30

Publications (1)

Publication Number Publication Date
ES366470A1 true ES366470A1 (es) 1971-03-16

Family

ID=24914845

Family Applications (1)

Application Number Title Priority Date Filing Date
ES366470A Expired ES366470A1 (es) 1968-04-30 1969-04-25 Un procedimiento para la preparacion de pirazinoilgunidinasy pirazinomidoguanidinas.

Country Status (9)

Country Link
US (1) US3506662A (enExample)
AT (1) AT289136B (enExample)
BR (1) BR6908430D0 (enExample)
CH (1) CH511862A (enExample)
DK (1) DK143398C (enExample)
ES (1) ES366470A1 (enExample)
GB (1) GB1225714A (enExample)
NL (1) NL6902280A (enExample)
SE (1) SE367630B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) * 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
RU2015129065A (ru) 2012-12-17 2017-01-25 Пэрион Сайенсиз, Инк. Производные хлор-пиразинкарбоксамида, обладающие активностью блокирования эпителиальных натриевых каналов
CN104995178B (zh) 2012-12-17 2018-06-26 帕里昂科学公司 3，5-二氨基-6-氯-n-(n-(4-苯基丁基)甲脒基)吡嗪-2-甲酰胺化合物
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3432502A (en) * 1966-08-25 1969-03-11 Merck & Co Inc Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products

Also Published As

Publication number Publication date
SE367630B (enExample) 1974-06-04
CH511862A (de) 1971-08-31
GB1225714A (enExample) 1971-03-24
DK143398C (da) 1981-12-14
AT289136B (de) 1971-04-13
NL6902280A (enExample) 1969-11-03
US3506662A (en) 1970-04-14
DK143398B (da) 1981-08-17
BR6908430D0 (pt) 1973-01-04

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