ES364943A1 - A procedure for the preparation of new heterociclic compounds of nitrogenated structure. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A process for the preparation of new heterocyclic compounds with nitrogen structure of the general formula **(See formula)** in which X1 and X2, the same or different, represent hydrogen, a halogen atom, an alcohol radical, an alkoxy radical, a trihalogenomotyl or nitro group; represents a radical-COOH, -COOR'(where R' is an aliphatic radical or the hydroxy radical of a glycol) or CON (see formula) (where A and B are hydrogen or a substituted or unsubstituted aliphatic radical); R2 represents hydrogen, an unsubstituted lower aliphatic radial, an at least disubstituted or unsubstituted aryl radical, an aryl-aliphatic radical, a thienyl, beta-pyridyl or furyl radical; X1 or X2 cannot represent a halogen atom, an alkoxy radical or the trifluoromethyl group when R2 represents the phenyl group, characterized in that it is subjected to an orthophenylenediamine of general formula **(See formula)** in which the substituents X1 and X2 have the aforementioned definitions, and R represents hydrogen, an alcohol radical or the hydroxy radical of m glycol, to the action of an organic carboxylic acid or a functional derivative thereof, to form an N -acyl-ortho-phenylenediamine, of general formula: **(See formula)** in which the substituents X1, X2, R and R2 maintain the aforementioned meanings; and then the latter is subjected to cycle closure by the action of a dehydrating agent and the desired benzimidazole is isolated. (Machine-translation by Google Translate, not legally binding)