ES361322A1 - Procedure for the preparation of pancreozymine and secretine. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of pancreozymine and secretine. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES361322A1 ES361322A1 ES361322A ES361322A ES361322A1 ES 361322 A1 ES361322 A1 ES 361322A1 ES 361322 A ES361322 A ES 361322A ES 361322 A ES361322 A ES 361322A ES 361322 A1 ES361322 A1 ES 361322A1
- Authority
- ES
- Spain
- Prior art keywords
- solution
- precipitate
- hormone
- secretine
- pancreozymine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01G—WEIGHING
- G01G3/00—Weighing apparatus characterised by the use of elastically-deformable members, e.g. spring balances
- G01G3/10—Weighing apparatus characterised by the use of elastically-deformable members, e.g. spring balances wherein the torsional deformation of a weighing element is measured
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
Abstract
Procedure for the preparation of pancreozymine and secretine, characterized by the operations consisting in contacting the duodenos of freshly extracted animals with diluted hydrochloric acid in order to obtain a crude hormone solution, to effect a relapse on the crude hormone solution in hydrochloric acid, with the help of sodium chloride, which precipitates the peptides, to obtain a semi-purified hormone solution, make several solutions of the latter solution using sodium chloride, which allow the elimination of impurities, the concentration of the solutions and the precipitation and iso- of vasodilatin and the inactive proteins at ph values of 5.2, 4 and 7.5 approximately, to obtain a solution of purified hormone, precipitate the hormone of this last solution with trichloroacetic acid, washing the precipitate with solvents suitable organic and drying after vacuum protected from the wet d to obtain a purified hormonal extract, treat the hormonal extract of duodenum with ethanol, which forms an ethanolic solution whose ph is successively regulated to approximately 5.2 to precipitate the vasodilatine that is eliminated and to approximately 7.5 to precipitate the proteins that the resulting ethanolic solution whose ph has been brought to about 3 to precipitate the desired extract which can eventually be dried to the state of a white powder and separate the pancreozymine and secretine are then removed and then treated with acetone and anhydrous ether. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR132868A FR1605434A (en) | 1967-12-19 | 1967-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES361322A1 true ES361322A1 (en) | 1970-11-16 |
Family
ID=8643434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES361322A Expired ES361322A1 (en) | 1967-12-19 | 1968-12-11 | Procedure for the preparation of pancreozymine and secretine. (Machine-translation by Google Translate, not legally binding) |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES361322A1 (en) |
| FR (1) | FR1605434A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815946A (en) * | 1981-07-21 | 1983-01-29 | Eisai Co Ltd | Novel heptadecapeptide |
-
1967
- 1967-12-19 FR FR132868A patent/FR1605434A/fr not_active Expired
-
1968
- 1968-12-11 ES ES361322A patent/ES361322A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1605434A (en) | 1975-10-17 |
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