GB1146565A - Process for extracting and recovering active polypeptides from animal organs - Google Patents
Process for extracting and recovering active polypeptides from animal organsInfo
- Publication number
- GB1146565A GB1146565A GB1435067A GB1435067A GB1146565A GB 1146565 A GB1146565 A GB 1146565A GB 1435067 A GB1435067 A GB 1435067A GB 1435067 A GB1435067 A GB 1435067A GB 1146565 A GB1146565 A GB 1146565A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- sulphosalicylic acid
- precipitate
- extracting
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1,146,565. Kallikrein and tripsin inhibitor. RICHTER GEDEON VEGYESZETI GYAR R.T. 29 March, 1967 [5 April, 1966], No. 14350/67. Heading C3H. A process for the preparation of a polypeptide, having a kallikrein- and tripsininactivating effect, in high purity and concentration from purified animal organ extracts includes the steps of cooling a solution obtained after deproteinizing said purified animal organ extracts to a temperature below 15‹ C. in the presence of from 2 to 10% (W/V) sulphosalicylic acid, separating the precipitate formed, dissolving said precipitate in water and removing traces of sulphosalicylic acid from the solution so obtained. The deproteinizing may be brought about by a prior treatment with sulphosalicylic acid at a higher temperature, for example 20‹ C., followed by centrifugation; alternatively the solution may be deproteinized with trichloroacetic acid. The traces of sulphosalicylic acid may be removed from the solution of the precipitate by treatment with anion exchange resin.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HUGO000980 | 1966-04-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1146565A true GB1146565A (en) | 1969-03-26 |
Family
ID=10996657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1435067A Expired GB1146565A (en) | 1966-04-05 | 1967-03-29 | Process for extracting and recovering active polypeptides from animal organs |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT270858B (en) |
| DE (1) | DE1617766B1 (en) |
| DK (1) | DK114853B (en) |
| GB (1) | GB1146565A (en) |
-
1967
- 1967-03-29 GB GB1435067A patent/GB1146565A/en not_active Expired
- 1967-03-29 AT AT296867A patent/AT270858B/en active
- 1967-03-31 DK DK192067A patent/DK114853B/en not_active IP Right Cessation
- 1967-04-05 DE DE1967R0045688 patent/DE1617766B1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AT270858B (en) | 1969-05-12 |
| DE1617766B1 (en) | 1970-06-25 |
| DK114853B (en) | 1969-08-11 |
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