GB1070870A - Process for extracting and recovering kallikrien-and trypsin-inactivating polypeptides - Google Patents

Process for extracting and recovering kallikrien-and trypsin-inactivating polypeptides

Info

Publication number
GB1070870A
GB1070870A GB4954865A GB4954865A GB1070870A GB 1070870 A GB1070870 A GB 1070870A GB 4954865 A GB4954865 A GB 4954865A GB 4954865 A GB4954865 A GB 4954865A GB 1070870 A GB1070870 A GB 1070870A
Authority
GB
United Kingdom
Prior art keywords
trypsin
kallikrien
recovering
extracting
inactivating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4954865A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of GB1070870A publication Critical patent/GB1070870A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Kallikrein- and trypsin-inactivating polypetides are obtained from animal organs (spleen, pancreas, parotid glands, lung, liver, kidney &c.) by extraction with an aqueous solution containing phosphoric, sulphuric or oxalic acid followed by treating the extract with a metal oxide and/or hydroxide which forms a salt with the acid used having a solubility product less than 10-4, removing the precipitate and adsorbing the polypeptide from the supernatant on an aluminosilicate (natural or synthetic) at pH 5-7 from which it is eluted with an acidified mixture (pH not greater than 3) of a polar organic solvent and water. The eluate may then be further purified by known methods.
GB4954865A 1964-11-27 1965-11-22 Process for extracting and recovering kallikrien-and trypsin-inactivating polypeptides Expired GB1070870A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUGO000937 1964-11-27
HUGO000956 1965-06-11

Publications (1)

Publication Number Publication Date
GB1070870A true GB1070870A (en) 1967-06-07

Family

ID=26318470

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4954865A Expired GB1070870A (en) 1964-11-27 1965-11-22 Process for extracting and recovering kallikrien-and trypsin-inactivating polypeptides

Country Status (4)

Country Link
AT (1) AT263999B (en)
DE (1) DE1492114A1 (en)
DK (1) DK116152B (en)
GB (1) GB1070870A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113684099A (en) * 2021-07-23 2021-11-23 南昌大学 Method for extracting linseed oil and cyclopeptide from waste argil

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113684099A (en) * 2021-07-23 2021-11-23 南昌大学 Method for extracting linseed oil and cyclopeptide from waste argil

Also Published As

Publication number Publication date
DK116152B (en) 1969-12-15
DE1492114A1 (en) 1970-09-24
AT263999B (en) 1968-08-12

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