ES361100A1 - Procedimiento para la obtencion de derivados de 17-alfa- aciloxi-11beta-metil-19-norpregn-4-eno-3,20-dionas. - Google Patents
Procedimiento para la obtencion de derivados de 17-alfa- aciloxi-11beta-metil-19-norpregn-4-eno-3,20-dionas.Info
- Publication number
- ES361100A1 ES361100A1 ES361100A ES361100A ES361100A1 ES 361100 A1 ES361100 A1 ES 361100A1 ES 361100 A ES361100 A ES 361100A ES 361100 A ES361100 A ES 361100A ES 361100 A1 ES361100 A1 ES 361100A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- compounds
- ones
- prepared
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000003301 hydrolyzing effect Effects 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- HZNVUJQVZSTENZ-UHFFFAOYSA-N 2,3-dichloro-5,6-dicyano-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(C#N)=C(C#N)C1=O HZNVUJQVZSTENZ-UHFFFAOYSA-N 0.000 abstract 2
- 238000006027 Birch reduction reaction Methods 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000002084 enol ethers Chemical class 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 abstract 2
- -1 metalloid halide Chemical class 0.000 abstract 2
- 238000007254 oxidation reaction Methods 0.000 abstract 2
- 238000006722 reduction reaction Methods 0.000 abstract 2
- 235000018185 Betula X alpestris Nutrition 0.000 abstract 1
- 235000018212 Betula X uliginosa Nutrition 0.000 abstract 1
- 241000551547 Dione <red algae> Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000010306 acid treatment Methods 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- QQVDYSUDFZZPSU-UHFFFAOYSA-M chloromethylidene(dimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)=CCl QQVDYSUDFZZPSU-UHFFFAOYSA-M 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000018044 dehydration Effects 0.000 abstract 1
- 238000006297 dehydration reaction Methods 0.000 abstract 1
- 238000006356 dehydrogenation reaction Methods 0.000 abstract 1
- 238000006345 epimerization reaction Methods 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 230000033444 hydroxylation Effects 0.000 abstract 1
- 238000005805 hydroxylation reaction Methods 0.000 abstract 1
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000006317 isomerization reaction Methods 0.000 abstract 1
- 229910052752 metalloid Inorganic materials 0.000 abstract 1
- MCSAJNNLRCFZED-UHFFFAOYSA-N nitroethane Chemical compound CC[N+]([O-])=O MCSAJNNLRCFZED-UHFFFAOYSA-N 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 238000005502 peroxidation Methods 0.000 abstract 1
- 238000000197 pyrolysis Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68898867A | 1967-12-08 | 1967-12-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES361100A1 true ES361100A1 (es) | 1970-10-16 |
Family
ID=24766615
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES361100A Expired ES361100A1 (es) | 1967-12-08 | 1968-12-05 | Procedimiento para la obtencion de derivados de 17-alfa- aciloxi-11beta-metil-19-norpregn-4-eno-3,20-dionas. |
| ES379193A Expired ES379193A1 (es) | 1967-12-08 | 1970-04-30 | Procedimiento para la obtencion de derivados de 17 alfa-hi-droxi-ii beta-metil - 19 - norpregn - 4 - eno - 3,20 - dio- na. |
| ES379195A Expired ES379195A1 (es) | 1967-12-08 | 1970-04-30 | Procedimiento para la obtencion de derivados de 17 alfa- acetoxi-6-alfa-cloro-ii beta - metil - 19 - norpregn - 4 - eno-3,20-diona. |
| ES379196A Expired ES379196A1 (es) | 1967-12-08 | 1970-04-30 | Procedimiento para la obtencion de derivados de 3 beta, 17 alfa-biacetoxi-ii beta-metil-19-norpregn-4-en-20-ona. |
| ES70379194A Expired ES379194A1 (es) | 1967-12-08 | 1970-04-30 | Procedimiento para la obtencion de derivados de 17 alfa- acetoxi-ii beta-metil-19-norpregn-4,6-dieno-3,20-diona. |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES379193A Expired ES379193A1 (es) | 1967-12-08 | 1970-04-30 | Procedimiento para la obtencion de derivados de 17 alfa-hi-droxi-ii beta-metil - 19 - norpregn - 4 - eno - 3,20 - dio- na. |
| ES379195A Expired ES379195A1 (es) | 1967-12-08 | 1970-04-30 | Procedimiento para la obtencion de derivados de 17 alfa- acetoxi-6-alfa-cloro-ii beta - metil - 19 - norpregn - 4 - eno-3,20-diona. |
| ES379196A Expired ES379196A1 (es) | 1967-12-08 | 1970-04-30 | Procedimiento para la obtencion de derivados de 3 beta, 17 alfa-biacetoxi-ii beta-metil-19-norpregn-4-en-20-ona. |
| ES70379194A Expired ES379194A1 (es) | 1967-12-08 | 1970-04-30 | Procedimiento para la obtencion de derivados de 17 alfa- acetoxi-ii beta-metil-19-norpregn-4,6-dieno-3,20-diona. |
Country Status (17)
| Country | Link |
|---|---|
| AT (4) | AT297955B (cs) |
| BE (1) | BE725078A (cs) |
| CH (3) | CH503008A (cs) |
| CY (1) | CY756A (cs) |
| DE (1) | DE1813083B2 (cs) |
| DK (1) | DK124882B (cs) |
| ES (5) | ES361100A1 (cs) |
| FI (1) | FI45552C (cs) |
| FR (1) | FR8324M (cs) |
| GB (1) | GB1235742A (cs) |
| IE (1) | IE32820B1 (cs) |
| IL (1) | IL31232A (cs) |
| MY (1) | MY7400268A (cs) |
| NL (1) | NL155556B (cs) |
| NO (1) | NO129570B (cs) |
| SE (3) | SE345263B (cs) |
| YU (2) | YU33974B (cs) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH606088A5 (cs) * | 1970-07-29 | 1978-10-13 | Richter Gedeon Vegyeszet | |
| HU230397B1 (hu) * | 2013-11-25 | 2016-04-28 | Richter Gedeon Nyrt. | Eljárás (11b,17a)-17-acetoxi-11-metil-19-norpregn-4-én-3,20-dion előállítására |
| CN109575098B (zh) * | 2019-01-18 | 2021-01-01 | 湖南成大生物科技有限公司 | 诺孕美特的合成方法 |
-
1968
- 1968-12-05 FI FI683505A patent/FI45552C/fi active
- 1968-12-05 ES ES361100A patent/ES361100A1/es not_active Expired
- 1968-12-06 CH CH3371A patent/CH503008A/de not_active IP Right Cessation
- 1968-12-06 CH CH3471A patent/CH503009A/de not_active IP Right Cessation
- 1968-12-06 NO NO04896/68A patent/NO129570B/no unknown
- 1968-12-06 DK DK599568AA patent/DK124882B/da unknown
- 1968-12-06 BE BE725078D patent/BE725078A/xx unknown
- 1968-12-06 SE SE16706/68A patent/SE345263B/xx unknown
- 1968-12-06 GB GB58044/68A patent/GB1235742A/en not_active Expired
- 1968-12-06 DE DE1813083A patent/DE1813083B2/de active Granted
- 1968-12-06 AT AT684770A patent/AT297955B/de not_active IP Right Cessation
- 1968-12-06 FR FR177069A patent/FR8324M/fr not_active Expired
- 1968-12-06 AT AT684570A patent/AT301055B/de not_active IP Right Cessation
- 1968-12-06 AT AT1192368A patent/AT293634B/de not_active IP Right Cessation
- 1968-12-06 AT AT684670A patent/AT297954B/de not_active IP Right Cessation
- 1968-12-06 CH CH1830968A patent/CH503004A/de not_active IP Right Cessation
- 1968-12-06 YU YU2873/68A patent/YU33974B/xx unknown
- 1968-12-06 SE SE11170/71A patent/SE365210B/xx unknown
- 1968-12-06 IL IL31232A patent/IL31232A/xx unknown
- 1968-12-06 SE SE11171/71A patent/SE365211B/xx unknown
- 1968-12-09 IE IE1496/68A patent/IE32820B1/xx unknown
- 1968-12-09 NL NL6817626.A patent/NL155556B/xx unknown
-
1970
- 1970-04-30 ES ES379193A patent/ES379193A1/es not_active Expired
- 1970-04-30 ES ES379195A patent/ES379195A1/es not_active Expired
- 1970-04-30 ES ES379196A patent/ES379196A1/es not_active Expired
- 1970-04-30 ES ES70379194A patent/ES379194A1/es not_active Expired
-
1974
- 1974-09-18 CY CY75674A patent/CY756A/xx unknown
- 1974-12-30 MY MY268/74A patent/MY7400268A/xx unknown
-
1975
- 1975-03-17 YU YU652/75A patent/YU34301B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU65275A (en) | 1978-10-31 |
| CH503008A (de) | 1971-02-15 |
| FR8324M (cs) | 1970-12-07 |
| IE32820L (en) | 1969-06-08 |
| YU34301B (en) | 1979-04-30 |
| AT301055B (de) | 1972-08-25 |
| SE365211B (cs) | 1974-03-18 |
| IL31232A0 (en) | 1969-02-27 |
| YU287368A (en) | 1978-02-28 |
| DE1813083A1 (de) | 1969-10-02 |
| ES379196A1 (es) | 1972-09-01 |
| IL31232A (en) | 1972-12-29 |
| ES379193A1 (es) | 1972-09-01 |
| YU33974B (en) | 1978-09-08 |
| BE725078A (cs) | 1969-06-06 |
| NO129570B (cs) | 1974-04-29 |
| ES379195A1 (es) | 1972-09-01 |
| IE32820B1 (en) | 1973-12-12 |
| AT293634B (de) | 1971-10-25 |
| CH503009A (de) | 1971-02-15 |
| AT297955B (de) | 1972-04-25 |
| FI45552B (cs) | 1972-04-04 |
| SE345263B (cs) | 1972-05-23 |
| SE365210B (cs) | 1974-03-18 |
| GB1235742A (en) | 1971-06-16 |
| DK124882B (da) | 1972-12-04 |
| MY7400268A (en) | 1974-12-31 |
| NL6817626A (cs) | 1969-06-10 |
| CH503004A (de) | 1971-02-15 |
| FI45552C (fi) | 1972-07-10 |
| CY756A (en) | 1974-09-18 |
| ES379194A1 (es) | 1972-09-01 |
| DE1813083B2 (de) | 1974-02-07 |
| NL155556B (nl) | 1978-01-16 |
| AT297954B (de) | 1972-04-25 |
| DE1813083C3 (cs) | 1974-09-19 |
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