ES358028A1 - Tropic acid esters - Google Patents

Tropic acid esters

Info

Publication number
ES358028A1
ES358028A1 ES358028A ES358028A ES358028A1 ES 358028 A1 ES358028 A1 ES 358028A1 ES 358028 A ES358028 A ES 358028A ES 358028 A ES358028 A ES 358028A ES 358028 A1 ES358028 A1 ES 358028A1
Authority
ES
Spain
Prior art keywords
branched
compounds
group
atoms
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES358028A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19671670268 external-priority patent/DE1670268A1/en
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES358028A1 publication Critical patent/ES358028A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of Formula (I) where R 1 is H or acyl R 2 is the group II or -O-A-NR 3 R 4 n is 1,2 or 3 A is an aliphatic chain containing at least 2C which may be branched and in which the O and N atoms are directly bonded to different C atoms R 3 is a straight or branched chain, saturated or unsaturated aliphatic group or cycloalkyl R 4 is as R 3 or is an alkylene group which may be branched and/or contain a hetero atom and which extends from the adjacent N of NR 3 R 4 to a C atom of A to give a 5-7 membered heterocycle or R 3 and R 4 together represent a 4-6C alkylene group which may be branched and/or contain a hetero atom are prepared by reduction of a compound IV to give I where R 1 is H, followed if necessary by acylation to give I where R 1 is acyl. Certain of compounds I are novel viz. those where R 1 and R 2 are as defined above with the provisos that R 4 is not as R 3 except where A has 2C atoms only and that where R 1 is H, -ANR 3 R 4 is not an N-(straight or branched chain saturated or unsaturated aliphatic or cycloalkyl) - 3 - piperidyl, CH 2 CH 2 N(CH 3 ) 2 or CH 2 CH 2 N(C 2 H 5 ) 2 group. The acid addition salts and quaternary ammonium derivatives are also novel. Intermediates isolated are the compounds of Formula (IV) which are prepared by reaction of R 2 H with an alkyl [alpha]-formylphenylacetate. Pharmaceutical compositions comprise one of the novel compounds I together with a suitable carrier or diluent, are administered orally, rectally or parenterally and have spasmolytic activity.
ES358028A 1967-09-12 1968-09-11 Tropic acid esters Expired ES358028A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19671670268 DE1670268A1 (en) 1967-09-12 1967-09-12 Tropic acid esters and process for their preparation

Publications (1)

Publication Number Publication Date
ES358028A1 true ES358028A1 (en) 1970-06-01

Family

ID=5686300

Family Applications (1)

Application Number Title Priority Date Filing Date
ES358028A Expired ES358028A1 (en) 1967-09-12 1968-09-11 Tropic acid esters

Country Status (7)

Country Link
AT (1) AT281024B (en)
BE (1) BE720749A (en)
CH (1) CH514588A (en)
ES (1) ES358028A1 (en)
FR (2) FR1589730A (en)
GB (1) GB1236962A (en)
IL (1) IL30693A0 (en)

Also Published As

Publication number Publication date
GB1236962A (en) 1971-06-23
IL30693A0 (en) 1968-11-27
CH514588A (en) 1971-10-31
FR1589730A (en) 1970-04-06
FR8308M (en) 1970-11-23
BE720749A (en) 1969-03-12
AT281024B (en) 1970-05-11

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