ES354273A1 - Procedimiento para la produccion de compuestos de 2,4-dia- mino-6-(nitrosamino sustituido) quinazolina. - Google Patents
Procedimiento para la produccion de compuestos de 2,4-dia- mino-6-(nitrosamino sustituido) quinazolina.Info
- Publication number
- ES354273A1 ES354273A1 ES354273A ES354273A ES354273A1 ES 354273 A1 ES354273 A1 ES 354273A1 ES 354273 A ES354273 A ES 354273A ES 354273 A ES354273 A ES 354273A ES 354273 A1 ES354273 A1 ES 354273A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- diamino
- prepared
- methyl
- chlorobenzonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- LJBWEZVYRBKOCI-UHFFFAOYSA-N 2,4,6-triaminoquinazoline Chemical compound N1=C(N)N=C(N)C2=CC(N)=CC=C21 LJBWEZVYRBKOCI-UHFFFAOYSA-N 0.000 abstract 2
- -1 2,4-diamino-6-(substituted amino)-quinazoline Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- MEJVTQKBWPYBFG-UHFFFAOYSA-N 2-amino-6-chlorobenzonitrile Chemical compound NC1=CC=CC(Cl)=C1C#N MEJVTQKBWPYBFG-UHFFFAOYSA-N 0.000 abstract 1
- WQWQHJNUHQEGTN-UHFFFAOYSA-N 2-chloro-6-methylbenzonitrile Chemical compound CC1=CC=CC(Cl)=C1C#N WQWQHJNUHQEGTN-UHFFFAOYSA-N 0.000 abstract 1
- VRWMKBVLNWINBB-UHFFFAOYSA-N 5-chloroquinazoline-2,4-diamine hydrochloride Chemical compound Cl.NC1=NC2=CC=CC(=C2C(=N1)N)Cl VRWMKBVLNWINBB-UHFFFAOYSA-N 0.000 abstract 1
- UVBLYZRPSXSSQT-UHFFFAOYSA-N 6-chloro-2-methyl-3-nitrobenzonitrile Chemical compound CC1=C([N+]([O-])=O)C=CC(Cl)=C1C#N UVBLYZRPSXSSQT-UHFFFAOYSA-N 0.000 abstract 1
- YZMJNZRTRWPJFY-UHFFFAOYSA-N 6-nitroquinazoline-2,4-diamine Chemical class C1=C([N+]([O-])=O)C=CC2=NC(N)=NC(N)=C21 YZMJNZRTRWPJFY-UHFFFAOYSA-N 0.000 abstract 1
- YCJSTJSVSDPSRA-UHFFFAOYSA-N C(C)(=O)O.NC1=NC2=CC=C(C(=C2C(=N1)N)C)[N+](=O)[O-] Chemical compound C(C)(=O)O.NC1=NC2=CC=C(C(=C2C(=N1)N)C)[N+](=O)[O-] YCJSTJSVSDPSRA-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- STIAPHVBRDNOAJ-UHFFFAOYSA-N carbamimidoylazanium;carbonate Chemical compound NC(N)=N.NC(N)=N.OC(O)=O STIAPHVBRDNOAJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ROSHZDSDUDVRGH-UHFFFAOYSA-N cyanamide;dihydrochloride Chemical compound Cl.Cl.NC#N ROSHZDSDUDVRGH-UHFFFAOYSA-N 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 229910017604 nitric acid Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- XELRMPRLCPFTBH-UHFFFAOYSA-N quinazoline-2,4-diamine Chemical class C1=CC=CC2=NC(N)=NC(N)=C21 XELRMPRLCPFTBH-UHFFFAOYSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB24462/67A GB1141249A (en) | 1967-05-25 | 1967-05-25 | New quinazoline compounds and methods for their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES354273A1 true ES354273A1 (es) | 1969-11-01 |
Family
ID=10212087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES354273A Expired ES354273A1 (es) | 1967-05-25 | 1968-05-24 | Procedimiento para la produccion de compuestos de 2,4-dia- mino-6-(nitrosamino sustituido) quinazolina. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3560502A (en:Method) |
| BE (1) | BE715667A (en:Method) |
| CH (1) | CH477452A (en:Method) |
| DE (1) | DE1770490C3 (en:Method) |
| DK (1) | DK116285B (en:Method) |
| ES (1) | ES354273A1 (en:Method) |
| FR (2) | FR1605537A (en:Method) |
| GB (1) | GB1141249A (en:Method) |
| IL (1) | IL30069A (en:Method) |
| NL (1) | NL6807380A (en:Method) |
| SE (1) | SE328291B (en:Method) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4071477A (en) * | 1976-06-10 | 1978-01-31 | Ciba-Geigy Corporation | Hydantoin diglycidyl compounds |
| HU180439B (en) * | 1977-12-29 | 1983-03-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 9-amino-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives |
| US4376858A (en) * | 1980-10-31 | 1983-03-15 | Warner Lambert Company | 2-4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline salts |
| GB8910722D0 (en) * | 1989-05-10 | 1989-06-28 | Smithkline Beckman Intercredit | Compounds |
| IL108630A0 (en) * | 1993-02-18 | 1994-05-30 | Fmc Corp | Insecticidal substituted 2,4-diaminoquinazolines |
| US6017922A (en) * | 1998-05-18 | 2000-01-25 | U.S. Bioscience, Inc. | Thermally stable trimetrexates and processes for producing the same |
-
1967
- 1967-05-25 GB GB24462/67A patent/GB1141249A/en not_active Expired
-
1968
- 1968-05-24 DE DE1770490A patent/DE1770490C3/de not_active Expired
- 1968-05-24 ES ES354273A patent/ES354273A1/es not_active Expired
- 1968-05-24 BE BE715667D patent/BE715667A/xx unknown
- 1968-05-24 NL NL6807380A patent/NL6807380A/xx unknown
- 1968-05-24 IL IL30069A patent/IL30069A/en unknown
- 1968-05-24 CH CH774068A patent/CH477452A/fr not_active IP Right Cessation
- 1968-05-24 FR FR152946A patent/FR1605537A/fr not_active Expired
- 1968-05-24 SE SE06998/68A patent/SE328291B/xx unknown
- 1968-05-24 US US731727A patent/US3560502A/en not_active Expired - Lifetime
- 1968-05-24 DK DK244268AA patent/DK116285B/da unknown
- 1968-08-23 FR FR163942A patent/FR7710M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1770490A1 (de) | 1972-03-02 |
| US3560502A (en) | 1971-02-02 |
| DE1770490B2 (de) | 1974-01-10 |
| IL30069A0 (en) | 1968-07-25 |
| IL30069A (en) | 1972-02-29 |
| FR1605537A (en:Method) | 1979-02-23 |
| CH477452A (fr) | 1969-08-31 |
| DE1770490C3 (de) | 1974-08-01 |
| SE328291B (en:Method) | 1970-09-14 |
| FR7710M (en:Method) | 1970-02-23 |
| GB1141249A (en) | 1969-01-29 |
| NL6807380A (en:Method) | 1968-11-26 |
| BE715667A (en:Method) | 1968-10-16 |
| DK116285B (da) | 1969-12-29 |
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