ES352896A1 - 1-(thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazines - Google Patents
1-(thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazinesInfo
- Publication number
- ES352896A1 ES352896A1 ES352896A ES352896A ES352896A1 ES 352896 A1 ES352896 A1 ES 352896A1 ES 352896 A ES352896 A ES 352896A ES 352896 A ES352896 A ES 352896A ES 352896 A1 ES352896 A1 ES 352896A1
- Authority
- ES
- Spain
- Prior art keywords
- general formula
- compound
- reacted
- prepared
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Novel compounds of the general formula wherein R1, R2 and R3, which may be the same or different, are hydrogen atoms or alkyl radicals containing up to 4 carbon atoms and A is a straight or branched chain alkylene radical containing 2-6 carbon atoms, and the acid addition salts thereof, are prepared by numerous methods, examples of which are as follows: (a) a compound of the general Formula II wherein X is chlorine, bromine or iodine, is reacted with a compound of the general Formula (b) a compound of the general Formula IV is reacted with a pyridyl derivative of the general formula (c) a compound of the general Formula VI is reacted with a compound of the general formula wherein X1 is a halogen atom or wherein the two substitutents X1 together represent an oxygen or sulphur atom (d) a compound of the general Formula X is reacted with a dihalo ethane of the formula X-CH 2 -CH 2 -X (f) a compound with unsaturation in the chain A is hydrogenated to give the corresponding compound wherein A is a saturated chain or (g) a compound of the general formula wherein B and D represent sulphur or oxygen atoms is reacted with an agent generating sulphur and an agent which strips off the elements of hydrogen sulphide, for example, phosphorus pentasulphide. Halides of the Formula II above are prepared by halogenation of the corresponding omegahydroxy compounds. Intermediates of general Formula IV above are prepared by reaction of the intermediate halides above with a piperazine. Amines of general Formula VI above are prepared by amination of the halides mentioned above. Diamines of general Formula X above are prepared by reaction of an amine mentioned above and ethylene imine followed by reaction with a 2-bromopyridine. Pharmaceutical compositions in conventional forms for oral, parenteral or topical application and having blood pressure lowering, narcosisprolonging, narcosis-potentiating, tranquillizing and/or neuroleptic activities comprise an above novel compound and a suitable medicinal carrier therefor.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEM0073664 | 1967-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES352896A1 true ES352896A1 (en) | 1969-08-01 |
Family
ID=7315173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES352896A Expired ES352896A1 (en) | 1967-04-20 | 1968-04-19 | 1-(thiazolyl-5-alkyl)-4-(pyridyl-2)-piperazines |
Country Status (5)
Country | Link |
---|---|
DE (1) | DE1695410A1 (en) |
ES (1) | ES352896A1 (en) |
FR (1) | FR7405M (en) |
GB (1) | GB1149110A (en) |
NL (1) | NL6804594A (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4456756A (en) * | 1981-08-03 | 1984-06-26 | Mead Johnson & Company | Spirothiazolidinyl piperazine derivatives |
US4367335A (en) * | 1981-08-03 | 1983-01-04 | Mead Johnson & Company | Thiazolidinylalkylene piperazine derivatives |
US4411901A (en) * | 1981-12-23 | 1983-10-25 | Mead Johnson & Company | Benzisothiazole and benzisoxazole piperazine derivatives |
MX174210B (en) * | 1987-02-17 | 1994-04-28 | Pfizer | PROCEDURE FOR THE PREPARATION OF ARILPIPERAZINYL-ALKYLENPHENYL-P-HETEROCICLICOS COMPOUNDS |
US4935424A (en) * | 1988-05-27 | 1990-06-19 | Warner-Lambert Company | 4 or 5-(substituted piperazinylalkyl)-2-aminothiazoles as antipsychotic agents |
DE3902316A1 (en) * | 1989-01-26 | 1990-08-02 | Lentia Gmbh | Novel piperazinylalkyl-3(2H)-pyridazinones, process for their preparation and their use as hypotensive agents |
DE4425145A1 (en) * | 1994-07-15 | 1996-01-18 | Basf Ag | Use of thiazole and thiadiazole compounds |
-
1967
- 1967-04-20 DE DE19671695410 patent/DE1695410A1/en active Pending
-
1968
- 1968-03-28 GB GB14989/68A patent/GB1149110A/en not_active Expired
- 1968-04-02 NL NL6804594A patent/NL6804594A/xx unknown
- 1968-04-17 FR FR148295A patent/FR7405M/fr not_active Expired
- 1968-04-19 ES ES352896A patent/ES352896A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR7405M (en) | 1969-11-03 |
GB1149110A (en) | 1969-04-16 |
DE1695410A1 (en) | 1971-04-08 |
NL6804594A (en) | 1968-10-21 |
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