ES352129A1 - Procedimiento de purificacion de alfa-6-deoxitetraciclinas. - Google Patents
Procedimiento de purificacion de alfa-6-deoxitetraciclinas.Info
- Publication number
- ES352129A1 ES352129A1 ES352129A ES352129A ES352129A1 ES 352129 A1 ES352129 A1 ES 352129A1 ES 352129 A ES352129 A ES 352129A ES 352129 A ES352129 A ES 352129A ES 352129 A1 ES352129 A1 ES 352129A1
- Authority
- ES
- Spain
- Prior art keywords
- oxytetracycline
- deoxy
- salt
- solution
- sulphosalicylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004100 Oxytetracycline Substances 0.000 title abstract 5
- 229960000625 oxytetracycline Drugs 0.000 title abstract 5
- 238000007670 refining Methods 0.000 title 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 3
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 3
- MOODSJOROWROTO-UHFFFAOYSA-N salicylsulfuric acid Chemical class OC(=O)C1=CC=CC=C1OS(O)(=O)=O MOODSJOROWROTO-UHFFFAOYSA-N 0.000 abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 3
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 2
- YCPXWRQRBFJBPZ-UHFFFAOYSA-N 5-sulfosalicylic acid Chemical compound OC(=O)C1=CC(S(O)(=O)=O)=CC=C1O YCPXWRQRBFJBPZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000001953 recrystallisation Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US630194A US3397231A (en) | 1967-04-12 | 1967-04-12 | Refining of alpha-6-deoxy-5-oxytetracycline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES352129A1 true ES352129A1 (es) | 1969-07-16 |
Family
ID=24526184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES352129A Expired ES352129A1 (es) | 1967-04-12 | 1968-03-29 | Procedimiento de purificacion de alfa-6-deoxitetraciclinas. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3397231A (en:Method) |
| JP (1) | JPS4843503B1 (en:Method) |
| BE (1) | BE713268A (en:Method) |
| BR (1) | BR6898210D0 (en:Method) |
| CH (1) | CH525865A (en:Method) |
| DE (1) | DE1768189B1 (en:Method) |
| DK (1) | DK126587B (en:Method) |
| ES (1) | ES352129A1 (en:Method) |
| FR (1) | FR1570644A (en:Method) |
| GB (1) | GB1122480A (en:Method) |
| IE (1) | IE31825B1 (en:Method) |
| NL (1) | NL6805123A (en:Method) |
| SE (1) | SE320659B (en:Method) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA920124A (en) * | 1969-06-12 | 1973-01-30 | Marcus Israel | Water-soluble tetracyclines |
| US4061676A (en) * | 1970-07-03 | 1977-12-06 | Ivan Villax | Recovery of doxycycline and products thereof |
| US3795707A (en) * | 1970-12-28 | 1974-03-05 | Rachelle Labor Italia Spa | Manufacture of alpha-6-deoxytetracyclines |
| DK386784A (da) * | 1983-08-17 | 1985-02-18 | Hovione Int Ltd | Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner |
| ATE139992T1 (de) * | 1992-04-06 | 1996-07-15 | Pliva Handels Gmbh | Verfahren und zwischenprodukte für die reinigung von oxytetracycline |
| CN114835603A (zh) * | 2022-06-17 | 2022-08-02 | 盐城苏海制药有限公司 | 一种由氢化物直接合成盐酸多西环素的合成方法 |
-
1967
- 1967-04-12 US US630194A patent/US3397231A/en not_active Expired - Lifetime
- 1967-07-11 GB GB38161/67A patent/GB1122480A/en not_active Expired
-
1968
- 1968-03-20 IE IE318/68A patent/IE31825B1/xx unknown
- 1968-03-29 ES ES352129A patent/ES352129A1/es not_active Expired
- 1968-04-03 SE SE4447/68A patent/SE320659B/xx unknown
- 1968-04-04 BE BE713268D patent/BE713268A/xx not_active IP Right Cessation
- 1968-04-08 CH CH515068A patent/CH525865A/de not_active IP Right Cessation
- 1968-04-09 BR BR198210/68A patent/BR6898210D0/pt unknown
- 1968-04-10 NL NL6805123A patent/NL6805123A/xx unknown
- 1968-04-10 DK DK163368AA patent/DK126587B/da unknown
- 1968-04-10 DE DE19681768189 patent/DE1768189B1/de active Pending
- 1968-04-10 FR FR1570644D patent/FR1570644A/fr not_active Expired
- 1968-04-12 JP JP43024549A patent/JPS4843503B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US3397231A (en) | 1968-08-13 |
| IE31825B1 (en) | 1973-01-10 |
| BR6898210D0 (pt) | 1973-05-10 |
| CH525865A (de) | 1972-07-31 |
| JPS4843503B1 (en:Method) | 1973-12-19 |
| NL6805123A (en:Method) | 1968-10-14 |
| BE713268A (en:Method) | 1968-10-04 |
| DE1768189B1 (de) | 1972-11-30 |
| FR1570644A (en:Method) | 1969-06-13 |
| SE320659B (en:Method) | 1970-02-16 |
| DK126587B (da) | 1973-07-30 |
| GB1122480A (en) | 1968-08-07 |
| IE31825L (en) | 1968-10-12 |
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