ES349158A1 - Procedure for the preparation of new 4-arilesulfonilsemicarbacidas 1-substitute. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Process for the preparation of new 1-substituted 4-arylsulfonylsemicarbacids, of the general formula i ** (see formula) ** Where R1 means hydrogen, halogen up to the atomic number 35, a lower alkyl, alkoxy, alkylthio or alkanoyl group or the amine group R2 means hydrogen; o well R1r2 means the trimethylenic or tetramethylene group, As well as its salts with inorganic or organic bases, characterized by reacting an isocyanate or isothiocyanate derivative of the general formula ii ** (see formula) ** Where R1'means hydrogen, halogen up to the atomic number 35, a lower alkyl, alkoxy, alkylthio or alkanoyl group or a radical which by hydrolysis, reduction or reductive dissociation can be transformed into an amine group, R2 means hydrogen, or R1'r2 means the trimethylenic or tetramethylene group and X means the oxygen or sulfur atom, Or a reactive functional derivative of a carbaminic or thiocarbaminic acid, of the general formula iii ** (see formula) ** Where X, r1', r2 or r1' r2 have the same meaning assigned to them in formulas i and ii, With 2-amino-2-aza-bicyclo [2.2.2] ectane or with an alkaline metal derivative of this compound, if desired in the presence of a condensing agent and, preferably, in an inert solvent; converting a derivative obtained from thiosemicarbacid to a semicarbacid derivative; if necessary, hydrolyze or reduce the product obtained from the reaction, to convert the group r1'to the free amine group; and, if desired, transform the product obtained from the reaction, with an inorganic or organic base, into a salt. (Machine-translation by Google Translate, not legally binding)