ES345735A1 - Procedimiento para la obtencion de 2,3,4,4a,5,6-hexahidro- 1h-pirazino (1,2-a) quinazolinas. - Google Patents
Procedimiento para la obtencion de 2,3,4,4a,5,6-hexahidro- 1h-pirazino (1,2-a) quinazolinas.Info
- Publication number
- ES345735A1 ES345735A1 ES345735A ES345735A ES345735A1 ES 345735 A1 ES345735 A1 ES 345735A1 ES 345735 A ES345735 A ES 345735A ES 345735 A ES345735 A ES 345735A ES 345735 A1 ES345735 A1 ES 345735A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrazino
- hexahydro
- quinoline
- chloride
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FXNGILFJMJFFBM-UHFFFAOYSA-N 1h-pyrazino[1,2-a]quinoline Chemical class C1=CC=C2N3CC=NC=C3C=CC2=C1 FXNGILFJMJFFBM-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 10
- 239000000543 intermediate Substances 0.000 abstract 9
- -1 p-methoxybenzoyl chloride 3 - (p - chlorobenzoyl) - 2,3,4,4a,5,6 - hexahydro- 1H pyrazino [1,2-a] quinoline Chemical compound 0.000 abstract 8
- CHIINPDGHUONJZ-UHFFFAOYSA-N 2,3,4,4a,5,6-hexahydro-1h-pyrazino[1,2-a]quinoline Chemical class C1=CC=C2N3CCNCC3CCC2=C1 CHIINPDGHUONJZ-UHFFFAOYSA-N 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- SEGQXSVTXMMYNS-UHFFFAOYSA-N 1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl(furan-2-yl)methanone Chemical compound O1C(=CC=C1)C(=O)N1CC2N(C3=CC=CC=C3CC2)CC1 SEGQXSVTXMMYNS-UHFFFAOYSA-N 0.000 abstract 1
- MTSSOURQBWGLJV-UHFFFAOYSA-N 1-(1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)-2-phenylethanone Chemical compound C1(=CC=CC=C1)CC(=O)N1CC2N(C3=CC=CC=C3CC2)CC1 MTSSOURQBWGLJV-UHFFFAOYSA-N 0.000 abstract 1
- SAPAWHGNIMQFMR-UHFFFAOYSA-N 1-(1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)ethanone Chemical compound C1=CC=C2N3CCN(C(=O)C)CC3CCC2=C1 SAPAWHGNIMQFMR-UHFFFAOYSA-N 0.000 abstract 1
- NTIJTEBBAZRBAW-UHFFFAOYSA-N 1-benzoyl-6-methyl-2h-quinoline-2-carbonitrile Chemical compound N#CC1C=CC2=CC(C)=CC=C2N1C(=O)C1=CC=CC=C1 NTIJTEBBAZRBAW-UHFFFAOYSA-N 0.000 abstract 1
- OFTKFKYVSBNYEC-UHFFFAOYSA-N 2-furoyl chloride Chemical compound ClC(=O)C1=CC=CO1 OFTKFKYVSBNYEC-UHFFFAOYSA-N 0.000 abstract 1
- VMZCDNSFRSVYKQ-UHFFFAOYSA-N 2-phenylacetyl chloride Chemical compound ClC(=O)CC1=CC=CC=C1 VMZCDNSFRSVYKQ-UHFFFAOYSA-N 0.000 abstract 1
- XODLSVZKRPBFLU-UHFFFAOYSA-N N-[(6-methoxy-1,2,3,4-tetrahydroquinolin-2-yl)methyl]benzamide Chemical compound C(C1=CC=CC=C1)(=O)NCC1NC2=CC=C(C=C2CC1)OC XODLSVZKRPBFLU-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000006264 debenzylation reaction Methods 0.000 abstract 1
- JRVKTGJDUJGQEM-UHFFFAOYSA-N furan-2-yl-(8-methyl-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl)methanone Chemical compound O1C(=CC=C1)C(=O)N1CC2N(C3=CC=C(C=C3CC2)C)CC1 JRVKTGJDUJGQEM-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical class C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1436366A CH493546A (de) | 1966-10-05 | 1966-10-05 | Verfahren zur Herstellung neuer Pyrazino (1,2-a)-chinoline |
| CH156167 | 1967-02-02 | ||
| CH1136267 | 1967-08-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES345735A1 true ES345735A1 (es) | 1969-01-16 |
Family
ID=27173075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES345735A Expired ES345735A1 (es) | 1966-10-05 | 1967-10-04 | Procedimiento para la obtencion de 2,3,4,4a,5,6-hexahidro- 1h-pirazino (1,2-a) quinazolinas. |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE704690A (ja) |
| DE (1) | DE1670473A1 (ja) |
| ES (1) | ES345735A1 (ja) |
| FR (3) | FR1549373A (ja) |
| GB (1) | GB1143039A (ja) |
| GR (1) | GR36369B (ja) |
| NL (1) | NL6713503A (ja) |
-
1967
- 1967-09-27 DE DE19671670473 patent/DE1670473A1/de active Pending
- 1967-10-03 GB GB45003/67A patent/GB1143039A/en not_active Expired
- 1967-10-03 FR FR1549373D patent/FR1549373A/fr not_active Expired
- 1967-10-04 ES ES345735A patent/ES345735A1/es not_active Expired
- 1967-10-04 BE BE704690D patent/BE704690A/xx unknown
- 1967-10-04 NL NL6713503A patent/NL6713503A/xx unknown
- 1967-10-04 GR GR670136369A patent/GR36369B/el unknown
- 1967-12-29 FR FR134278A patent/FR7108M/fr not_active Expired
- 1967-12-29 FR FR134279A patent/FR7109M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR7109M (ja) | 1969-07-15 |
| BE704690A (ja) | 1968-04-04 |
| GB1143039A (en) | 1969-02-19 |
| DE1670473A1 (de) | 1971-02-11 |
| NL6713503A (ja) | 1968-04-08 |
| GR36369B (el) | 1969-02-04 |
| FR7108M (ja) | 1969-07-15 |
| FR1549373A (ja) | 1968-12-13 |
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