ES343513A1 - Un procedimiento para la preparacion de 1,6-dimetil-10 alfa-ergolina. - Google Patents
Un procedimiento para la preparacion de 1,6-dimetil-10 alfa-ergolina.Info
- Publication number
- ES343513A1 ES343513A1 ES343513A ES343513A ES343513A1 ES 343513 A1 ES343513 A1 ES 343513A1 ES 343513 A ES343513 A ES 343513A ES 343513 A ES343513 A ES 343513A ES 343513 A1 ES343513 A1 ES 343513A1
- Authority
- ES
- Spain
- Prior art keywords
- 10alpha
- ergoline
- dimethyl
- acid
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- AJLDKAZVAGCTKS-AADWAWOOSA-N (6aR,10aR)-4,7-dimethyl-5,5a,6,6a,8,9,10,10a-octahydroindolo[4,3-fg]quinoline Chemical class CN1CC2C[C@H]3N(CCC[C@@H]3C=3C=CC=C1C32)C AJLDKAZVAGCTKS-AADWAWOOSA-N 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- -1 heterocyclic carboxylic Chemical class 0.000 abstract 2
- RILZRCJGXSFXNE-UHFFFAOYSA-N 2-[4-(trifluoromethoxy)phenyl]ethanol Chemical compound OCCC1=CC=C(OC(F)(F)F)C=C1 RILZRCJGXSFXNE-UHFFFAOYSA-N 0.000 abstract 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CBYOKKIRJYELKD-AVPYDZBYSA-N [(6aR,9S,10aR)-4,7-dimethyl-5,5a,6,6a,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl]methanamine Chemical compound CN1CC2C[C@H]3N(C[C@@H](C[C@@H]3C=3C=CC=C1C=32)CN)C CBYOKKIRJYELKD-AVPYDZBYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2085166 | 1966-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES343513A1 true ES343513A1 (es) | 1968-10-16 |
Family
ID=11173007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES343513A Expired ES343513A1 (es) | 1966-07-29 | 1967-07-28 | Un procedimiento para la preparacion de 1,6-dimetil-10 alfa-ergolina. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3557118A (en, 2012) |
| AT (1) | AT278254B (en, 2012) |
| BE (1) | BE702014A (en, 2012) |
| DE (1) | DE1695752C3 (en, 2012) |
| ES (1) | ES343513A1 (en, 2012) |
| FI (1) | FI47767C (en, 2012) |
| GR (1) | GR36620B (en, 2012) |
| IL (1) | IL28388A (en, 2012) |
| NO (1) | NO119741B (en, 2012) |
| SE (1) | SE340284B (en, 2012) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR6915443D0 (pt) * | 1969-07-18 | 1973-03-13 | Farmaceutici Italia | Processo para a preparacao de derivados de ergolina |
| US3957785A (en) * | 1971-12-02 | 1976-05-18 | Societa' Farmaceutici Italia S.P.A. | Bβ-Pyrimidino-aminomethyl-10α-ergoline and 10α-methoxyergoline derivatives |
| CS171480B1 (en, 2012) * | 1974-03-19 | 1976-10-29 | ||
| CS177530B1 (en) * | 1974-07-19 | 1977-07-29 | Miroslav Semonsky | New nbeta-substituted derivatives of b-beta-aminoethyl-ergoline-i their salts and methods for the production thereof |
| US4348392A (en) * | 1974-07-19 | 1982-09-07 | Sandoz Ltd. | 8α-Substituted ergoline-I derivatives |
| US3985752A (en) * | 1974-12-06 | 1976-10-12 | Eli Lilly And Company | 6-Methyl-8-(substituted) methylergolines |
| IT1064473B (it) * | 1976-11-24 | 1985-02-18 | Simes | Sulfamoil derivati dell'8-beta-amminometilergolina |
| FR2421176A1 (fr) * | 1978-03-29 | 1979-10-26 | Sandoz Sa | Nouveaux derives de l'ergot de seigle, leur preparation et leur application comme medicaments |
| HU190105B (en) * | 1983-06-03 | 1986-08-28 | Gyogyszerkutato Intezet | Process for production of pirazolyl-methyl-ergolin- derivatives and their acid additional salts |
-
1967
- 1967-07-24 DE DE1695752A patent/DE1695752C3/de not_active Expired
- 1967-07-24 IL IL28388A patent/IL28388A/en unknown
- 1967-07-25 GR GR670136620A patent/GR36620B/el unknown
- 1967-07-25 US US655755A patent/US3557118A/en not_active Expired - Lifetime
- 1967-07-25 AT AT690467A patent/AT278254B/de not_active IP Right Cessation
- 1967-07-27 FI FI672059A patent/FI47767C/fi active
- 1967-07-27 NO NO169188A patent/NO119741B/no unknown
- 1967-07-28 SE SE10929/67*A patent/SE340284B/xx unknown
- 1967-07-28 BE BE702014D patent/BE702014A/xx unknown
- 1967-07-28 ES ES343513A patent/ES343513A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE340284B (en, 2012) | 1971-11-15 |
| FI47767B (en, 2012) | 1973-11-30 |
| DE1695752A1 (de) | 1972-03-30 |
| DE1695752B2 (de) | 1973-10-31 |
| DE1695752C3 (de) | 1974-06-06 |
| IL28388A (en) | 1971-11-29 |
| FI47767C (fi) | 1974-03-11 |
| GR36620B (el) | 1969-02-26 |
| AT278254B (de) | 1970-01-26 |
| NO119741B (en, 2012) | 1970-06-29 |
| BE702014A (en, 2012) | 1968-01-29 |
| US3557118A (en) | 1971-01-19 |
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