ES288887A1 - Un procedimiento para la preparación de nuevos derivados de la 6-metil y la 1,6-dimetil-ergolina - Google Patents
Un procedimiento para la preparación de nuevos derivados de la 6-metil y la 1,6-dimetil-ergolinaInfo
- Publication number
- ES288887A1 ES288887A1 ES288887A ES288887A ES288887A1 ES 288887 A1 ES288887 A1 ES 288887A1 ES 288887 A ES288887 A ES 288887A ES 288887 A ES288887 A ES 288887A ES 288887 A1 ES288887 A1 ES 288887A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- hydrogen
- ergoline
- translation
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1167062 | 1962-06-11 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES288887A1 true ES288887A1 (es) | 1963-12-16 |
Family
ID=11136772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES288887A Expired ES288887A1 (es) | 1962-06-11 | 1963-06-10 | Un procedimiento para la preparación de nuevos derivados de la 6-metil y la 1,6-dimetil-ergolina |
Country Status (8)
Country | Link |
---|---|
US (1) | US3228943A (es) |
AT (1) | AT258481B (es) |
BR (1) | BR6349779D0 (es) |
CH (1) | CH446367A (es) |
DK (1) | DK103780C (es) |
ES (1) | ES288887A1 (es) |
GB (1) | GB981827A (es) |
SE (1) | SE315904B (es) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3879554A (en) * | 1970-03-20 | 1975-04-22 | Farmaceutici Italia | Use of 1,6-dimethyl-8-{62 -(5-bromonicotinoyloxymethyl)-10 {60 -methoxyergoline in treating cerebral and peripheral metabolic vascular disorders |
NL159384B (nl) * | 1971-03-13 | 1979-02-15 | Farmaceutici Italia | Werkwijze voor het bereiden van een geneesmiddel met een adrenolytische activiteit, alsmede werkwijze voor het bereiden van een ester van 1-methyl-10-methoxylumilysergol. |
DE2330912C3 (de) * | 1972-06-22 | 1979-01-11 | Societa Farmaceutici Italia S.P.A., Mailand (Italien) | Verfahren zur Herstellung von Bromergolinverbindungen |
NL7400790A (es) * | 1973-02-02 | 1974-08-06 | ||
US3996228A (en) * | 1973-12-21 | 1976-12-07 | Societa' Farmaceutici Italia S.P.A. | Pyrimidinoaminoethyl ergoline derivatives |
US3929796A (en) * | 1974-08-02 | 1975-12-30 | Lilly Co Eli | Synthesis of penniclavine and elymoclavine |
US4199579A (en) * | 1975-03-14 | 1980-04-22 | Siphar S. A. | Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof |
US4054567A (en) * | 1975-08-11 | 1977-10-18 | Eli Lilly And Company | 6-Methyl-8β-hydroxymethyl-8-γ-substituted-9-ergolene compounds |
US4082753A (en) * | 1976-02-17 | 1978-04-04 | Eli Lilly And Company | Penniclavine acetonide |
YU40004B (en) * | 1977-07-21 | 1985-06-30 | Lek Tovarna Farmacevtskih | Praocess for preparing n-substituted esters of 9,10-dihydrlysergic acid |
IT1094965B (it) * | 1978-04-05 | 1985-08-10 | Corvi Mora E | Procedimento di preparazione di derivati del lisergolo |
US4382940A (en) * | 1979-12-06 | 1983-05-10 | Farmitalia Carlo Erba S.P.A. | Ercoline derivatives and therapeutic compositions having CNS affecting activity |
IT1173489B (it) * | 1984-03-27 | 1987-06-24 | Inverni Della Beffa Spa | Procedimento di preparazione di 1-metil-10alfa-metossilumilisergolo e di suci esteri,e intermedi per la loro preparazione |
IT1213206B (it) * | 1984-08-07 | 1989-12-14 | Inverni Della Beffa Spa | Procedimento per la preparazione di derivati del lisergolo. |
HU193782B (en) * | 1985-06-21 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for producing 2-halogeno-nicergoline derivatives and acid additional salts thereof |
FR2584720B1 (fr) * | 1985-07-11 | 1987-10-02 | Rhone Poulenc Sante | Procede de preparation de derives n-methyles de l'ergoline |
FR2584719B1 (fr) * | 1985-07-11 | 1987-10-02 | Rhone Poulenc Sante | Procede de preparation des derives n-methyles du lysergol et du methoxy-10a lumilysergol |
FR2584721B1 (fr) * | 1985-07-11 | 1987-10-02 | Rhone Poulenc Sante | Procede de preparation des derives n-methyles du dihydrolysergate de methyle ou du methoxylumilysergate de methyle |
US4713385A (en) * | 1985-10-01 | 1987-12-15 | Eli Lilly And Company | Alkoxy and dialkoxyalkyl esters of dihydrolysergic acid and related compounds useful as 5HT receptor antagonists |
US4683237A (en) * | 1985-12-20 | 1987-07-28 | Eli Lilly And Company | Fluoroalkyl esters of dihydrolysergic acid useful as 5HT2 receptor antagonists |
US5211504A (en) * | 1991-01-31 | 1993-05-18 | Roger Trudel | Adjustable manhole top |
FR2786100B1 (fr) | 1998-11-24 | 2002-03-01 | Aventis Laboratoire | Nouvelle application therapeutique de la nicergoline |
FR2786101B1 (fr) | 1998-11-24 | 2002-07-05 | Aventis Laboratoire | Utilisation de la nicergoline dans le traitement de la spasticite |
BR0313593A (pt) | 2002-08-19 | 2005-07-12 | Pfizer Prod Inc | Terapia de combinação para doenças hiperproliferativas |
US20050037063A1 (en) * | 2003-07-21 | 2005-02-17 | Bolton Anthony E. | Combined therapies |
US20060063803A1 (en) * | 2004-09-23 | 2006-03-23 | Pfizer Inc | 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
US8383660B2 (en) | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
EP2094643B1 (en) | 2006-12-01 | 2012-02-29 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
CA3125765A1 (en) | 2019-01-18 | 2020-07-23 | Astrazeneca Ab | Pcsk9 inhibitors and methods of use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3155667A (en) * | 1964-11-03 | Process for the preparation of | ||
GB786138A (en) * | 1955-02-04 | 1957-11-13 | Sandoz Ltd | New ergot alkaloid derivatives and process of making same |
-
1963
- 1963-06-04 US US28522963 patent/US3228943A/en not_active Expired - Lifetime
- 1963-06-06 GB GB22576/63A patent/GB981827A/en not_active Expired
- 1963-06-07 AT AT461263A patent/AT258481B/de active
- 1963-06-07 SE SE6306/63A patent/SE315904B/xx unknown
- 1963-06-07 DK DK270863AA patent/DK103780C/da active
- 1963-06-10 CH CH723163A patent/CH446367A/de unknown
- 1963-06-10 BR BR149779/63A patent/BR6349779D0/pt unknown
- 1963-06-10 ES ES288887A patent/ES288887A1/es not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH446367A (de) | 1967-11-15 |
BR6349779D0 (pt) | 1973-07-03 |
DK103780C (da) | 1966-02-21 |
US3228943A (en) | 1966-01-11 |
AT258481B (de) | 1967-11-27 |
DE1470241A1 (de) | 1969-12-11 |
SE315904B (es) | 1969-10-13 |
GB981827A (en) | 1965-01-27 |
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