ES334424A1 - Procedimiento para la produccion de compuestos glucosidos. - Google Patents
Procedimiento para la produccion de compuestos glucosidos.Info
- Publication number
- ES334424A1 ES334424A1 ES334424A ES334424A ES334424A1 ES 334424 A1 ES334424 A1 ES 334424A1 ES 334424 A ES334424 A ES 334424A ES 334424 A ES334424 A ES 334424A ES 334424 A1 ES334424 A1 ES 334424A1
- Authority
- ES
- Spain
- Prior art keywords
- demethyl
- epipodophyllotoxin
- vii
- organic solvent
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YVCVYCSAAZQOJI-JHQYFNNDSA-N 4'-demethylepipodophyllotoxin Chemical class COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YVCVYCSAAZQOJI-JHQYFNNDSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 abstract 3
- 239000003960 organic solvent Substances 0.000 abstract 3
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 abstract 2
- YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 abstract 2
- 229960001237 podophyllotoxin Drugs 0.000 abstract 2
- YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 abstract 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- FCSKOFQQCWLGMV-UHFFFAOYSA-N 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole Chemical compound O1N=C(C)C=C1CCCCCOC1=CC=C(C=2OCCN=2)C=C1Cl FCSKOFQQCWLGMV-UHFFFAOYSA-N 0.000 abstract 1
- 229910015900 BF3 Inorganic materials 0.000 abstract 1
- AYLIEDQYYJIGDP-UHFFFAOYSA-N [C]1=CC=CS1 Chemical group [C]1=CC=CS1 AYLIEDQYYJIGDP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 238000006136 alcoholysis reaction Methods 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 229940057499 anhydrous zinc acetate Drugs 0.000 abstract 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Substances FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 239000002786 epipodophyllotoxin derivative Substances 0.000 abstract 1
- 229930182478 glucoside Natural products 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 229910000474 mercury oxide Inorganic materials 0.000 abstract 1
- UKWHYYKOEPRTIC-UHFFFAOYSA-N mercury(ii) oxide Chemical compound [Hg]=O UKWHYYKOEPRTIC-UHFFFAOYSA-N 0.000 abstract 1
- 150000007530 organic bases Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- DJWUNCQRNNEAKC-UHFFFAOYSA-L zinc acetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O DJWUNCQRNNEAKC-UHFFFAOYSA-L 0.000 abstract 1
- 239000011787 zinc oxide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1723065A CH507934A (de) | 1965-12-14 | 1965-12-14 | Verfahren zur Herstellung eines neuen Glucosids |
| CH1723265A CH469000A (de) | 1965-12-14 | 1965-12-14 | Verfahren zur Herstellung neuer Glucoside |
| CH1722965 | 1965-12-14 | ||
| CH1470366 | 1966-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES334424A1 true ES334424A1 (es) | 1968-03-01 |
Family
ID=27429581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES334424A Expired ES334424A1 (es) | 1965-12-14 | 1966-12-12 | Procedimiento para la produccion de compuestos glucosidos. |
Country Status (15)
| Country | Link |
|---|---|
| AT (2) | AT298681B (en, 2012) |
| BE (1) | BE691066A (en, 2012) |
| CH (2) | CH469000A (en, 2012) |
| DK (2) | DK120849B (en, 2012) |
| ES (1) | ES334424A1 (en, 2012) |
| FI (2) | FI47357C (en, 2012) |
| FR (1) | FR6310M (en, 2012) |
| GB (1) | GB1163106A (en, 2012) |
| IL (3) | IL34853A (en, 2012) |
| NL (1) | NL6617379A (en, 2012) |
| NO (1) | NO120371B (en, 2012) |
| OA (1) | OA02648A (en, 2012) |
| SE (2) | SE370072B (en, 2012) |
| SU (1) | SU414788A3 (en, 2012) |
| YU (1) | YU33197B (en, 2012) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4713246A (en) * | 1984-03-19 | 1987-12-15 | Bristol-Myers Company | Etoposide oral dosage form |
| US4965348A (en) * | 1989-05-19 | 1990-10-23 | Bristol-Myers Company | Dimeric epipodophyllotoxin glucoside derivatives |
| US5036055A (en) * | 1989-06-07 | 1991-07-30 | Bristol-Myers Company | Acylated derivatives of etoposide |
-
1965
- 1965-12-14 CH CH1723265A patent/CH469000A/de unknown
- 1965-12-14 CH CH1723065A patent/CH507934A/de not_active IP Right Cessation
-
1966
- 1966-11-28 GB GB53218/66A patent/GB1163106A/en not_active Expired
- 1966-12-06 OA OA52682A patent/OA02648A/xx unknown
- 1966-12-09 NL NL6617379A patent/NL6617379A/xx unknown
- 1966-12-10 YU YU2331/66A patent/YU33197B/xx unknown
- 1966-12-12 IL IL34853A patent/IL34853A/xx unknown
- 1966-12-12 BE BE691066D patent/BE691066A/xx not_active IP Right Cessation
- 1966-12-12 IL IL27042A patent/IL27042A/xx unknown
- 1966-12-12 FI FI663294A patent/FI47357C/fi active
- 1966-12-12 AT AT1053668A patent/AT298681B/de active
- 1966-12-12 SU SU1118481A patent/SU414788A3/ru active
- 1966-12-12 ES ES334424A patent/ES334424A1/es not_active Expired
- 1966-12-12 AT AT1142266A patent/AT295048B/de not_active IP Right Cessation
- 1966-12-13 DK DK646366AA patent/DK120849B/da not_active IP Right Cessation
- 1966-12-13 SE SE03842/70A patent/SE370072B/xx unknown
- 1966-12-13 NO NO165984A patent/NO120371B/no unknown
- 1966-12-13 SE SE17094/66A patent/SE337595B/xx unknown
-
1967
- 1967-03-10 FR FR98340A patent/FR6310M/fr not_active Expired
-
1968
- 1968-03-15 DK DK112368AA patent/DK118826B/da not_active IP Right Cessation
-
1970
- 1970-07-06 IL IL34853A patent/IL34853A0/xx unknown
-
1971
- 1971-06-24 FI FI711801A patent/FI47358C/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| IL27042A (en) | 1971-04-28 |
| FI47357C (fi) | 1973-11-12 |
| DK120849B (da) | 1971-07-26 |
| CH507934A (de) | 1971-05-31 |
| YU233166A (en) | 1975-12-31 |
| GB1163106A (en) | 1969-09-04 |
| DK118826B (da) | 1970-10-12 |
| CH469000A (de) | 1969-02-28 |
| SU414788A3 (en, 2012) | 1974-02-05 |
| SE370072B (en, 2012) | 1974-09-30 |
| IL34853A (en) | 1971-04-28 |
| AT298681B (de) | 1972-05-25 |
| OA02648A (fr) | 1970-12-15 |
| FR6310M (en, 2012) | 1968-09-16 |
| YU33197B (en) | 1976-06-30 |
| FI47358B (en, 2012) | 1973-07-31 |
| BE691066A (en, 2012) | 1967-06-12 |
| AT295048B (de) | 1971-12-27 |
| FI47357B (en, 2012) | 1973-07-31 |
| NL6617379A (en, 2012) | 1967-06-15 |
| SE337595B (en, 2012) | 1971-08-16 |
| FI47358C (fi) | 1973-11-12 |
| NO120371B (en, 2012) | 1970-10-12 |
| IL34853A0 (en) | 1970-09-17 |
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