ES333932A1 - Procedimiento para la preparacion de bencenosulfonilureas. - Google Patents
Procedimiento para la preparacion de bencenosulfonilureas.Info
- Publication number
- ES333932A1 ES333932A1 ES333932A ES333932A ES333932A1 ES 333932 A1 ES333932 A1 ES 333932A1 ES 333932 A ES333932 A ES 333932A ES 333932 A ES333932 A ES 333932A ES 333932 A1 ES333932 A1 ES 333932A1
- Authority
- ES
- Spain
- Prior art keywords
- benzenesulphonyl
- cyclohexyl
- alkyl
- benzamido
- phenoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 phenylcyclopropyl Chemical group 0.000 abstract 12
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- UMGDCJDMYOKAJW-UHFFFAOYSA-N aminothiocarboxamide Natural products NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 3
- 239000004202 carbamide Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000012948 isocyanate Substances 0.000 abstract 2
- UKWHYYKOEPRTIC-UHFFFAOYSA-N mercury(ii) oxide Chemical compound [Hg]=O UKWHYYKOEPRTIC-UHFFFAOYSA-N 0.000 abstract 2
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 2
- OGLKKYALUKXVPQ-UHFFFAOYSA-N 2-chloro-5-nitrobenzoyl chloride Chemical compound [O-][N+](=O)C1=CC=C(Cl)C(C(Cl)=O)=C1 OGLKKYALUKXVPQ-UHFFFAOYSA-N 0.000 abstract 1
- BXVSAYBZSGIURM-UHFFFAOYSA-N 2-phenoxy-4h-1,3,2$l^{5}-benzodioxaphosphinine 2-oxide Chemical compound O1CC2=CC=CC=C2OP1(=O)OC1=CC=CC=C1 BXVSAYBZSGIURM-UHFFFAOYSA-N 0.000 abstract 1
- BMGKQFRMINVVPP-UHFFFAOYSA-N 2-phenoxybenzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1OC1=CC=CC=C1 BMGKQFRMINVVPP-UHFFFAOYSA-N 0.000 abstract 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 abstract 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- ALZKZGUTVJXYEF-UHFFFAOYSA-N benzenesulfonylcarbamic acid Chemical class OC(=O)NS(=O)(=O)C1=CC=CC=C1 ALZKZGUTVJXYEF-UHFFFAOYSA-N 0.000 abstract 1
- PVMBGVAQRSHDBB-UHFFFAOYSA-N benzenesulfonylthiourea Chemical class NC(=S)NS(=O)(=O)C1=CC=CC=C1 PVMBGVAQRSHDBB-UHFFFAOYSA-N 0.000 abstract 1
- GHDLZGOOOLEJKI-UHFFFAOYSA-N benzenesulfonylurea Chemical class NC(=O)NS(=O)(=O)C1=CC=CC=C1 GHDLZGOOOLEJKI-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 150000001714 carbamic acid halides Chemical class 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000006622 cycloheptylmethyl group Chemical group 0.000 abstract 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000006623 cyclooctylmethyl group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000036571 hydration Effects 0.000 abstract 1
- 238000006703 hydration reaction Methods 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- MZSJGCPBOVTKHR-UHFFFAOYSA-N isothiocyanatocyclohexane Chemical compound S=C=NC1CCCCC1 MZSJGCPBOVTKHR-UHFFFAOYSA-N 0.000 abstract 1
- 125000005358 mercaptoalkyl group Chemical group 0.000 abstract 1
- 229940101209 mercuric oxide Drugs 0.000 abstract 1
- RMAHPRNLQIRHIJ-UHFFFAOYSA-N methyl carbamimidate Chemical compound COC(N)=N RMAHPRNLQIRHIJ-UHFFFAOYSA-N 0.000 abstract 1
- UUFWPLHGJYIEBA-UHFFFAOYSA-N n-(iminomethylidene)benzenesulfonamide Chemical class N=C=NS(=O)(=O)C1=CC=CC=C1 UUFWPLHGJYIEBA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- GKKCIDNWFBPDBW-UHFFFAOYSA-M potassium cyanate Chemical compound [K]OC#N GKKCIDNWFBPDBW-UHFFFAOYSA-M 0.000 abstract 1
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical class NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1518895A DE1518895C3 (de) | 1965-12-02 | 1965-12-02 | Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES333932A1 true ES333932A1 (es) | 1968-06-01 |
Family
ID=7101860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES333932A Expired ES333932A1 (es) | 1965-12-02 | 1966-11-29 | Procedimiento para la preparacion de bencenosulfonilureas. |
| ES349857A Expired ES349857A1 (es) | 1965-12-02 | 1968-01-27 | Un procedimiento para la obtencion de preparados farmaceu- ticos con actividad depresora del azucar en sangre. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES349857A Expired ES349857A1 (es) | 1965-12-02 | 1968-01-27 | Un procedimiento para la obtencion de preparados farmaceu- ticos con actividad depresora del azucar en sangre. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US3621057A (en, 2012) |
| AT (4) | AT287002B (en, 2012) |
| BE (1) | BE690604A (en, 2012) |
| BR (1) | BR6685071D0 (en, 2012) |
| CH (3) | CH560681A5 (en, 2012) |
| CY (1) | CY566A (en, 2012) |
| DE (1) | DE1518895C3 (en, 2012) |
| DK (1) | DK120895B (en, 2012) |
| ES (2) | ES333932A1 (en, 2012) |
| FI (1) | FI45961C (en, 2012) |
| FR (2) | FR1510941A (en, 2012) |
| GB (1) | GB1171935A (en, 2012) |
| IL (1) | IL26927A (en, 2012) |
| IS (1) | IS809B6 (en, 2012) |
| LU (1) | LU52465A1 (en, 2012) |
| MC (1) | MC633A1 (en, 2012) |
| MY (1) | MY7100058A (en, 2012) |
| NL (1) | NL6616441A (en, 2012) |
| NO (1) | NO123645B (en, 2012) |
| OA (1) | OA02281A (en, 2012) |
| SE (1) | SE329608B (en, 2012) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518776A (en) * | 1982-07-19 | 1985-05-21 | Ciba Geigy Corporation | Process for producing sulfonylureas |
| EP2999691A4 (en) | 2013-05-21 | 2017-02-08 | Virginia Commonwealth University | Cryopyrin inhibitors for preventing and treating inflammation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE965234C (de) * | 1955-10-15 | 1957-06-06 | Hoechst Ag | Verfahren zur Herstellung von neuen Benzolsulfonylharnstoffen |
| GB815885A (en) * | 1956-08-10 | 1959-07-01 | Hoechst Ag | Sulphonyl-ureas and a process for their manufacture |
| DE1185180B (de) * | 1963-10-19 | 1965-01-14 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
-
1965
- 1965-12-02 DE DE1518895A patent/DE1518895C3/de not_active Expired
-
1966
- 1966-11-18 DK DK600566AA patent/DK120895B/da unknown
- 1966-11-22 NL NL6616441A patent/NL6616441A/xx unknown
- 1966-11-23 IL IL26927A patent/IL26927A/en unknown
- 1966-11-24 IS IS1612A patent/IS809B6/is unknown
- 1966-11-25 FI FI663124A patent/FI45961C/fi active
- 1966-11-29 US US597539A patent/US3621057A/en not_active Expired - Lifetime
- 1966-11-29 LU LU52465D patent/LU52465A1/xx unknown
- 1966-11-29 ES ES333932A patent/ES333932A1/es not_active Expired
- 1966-11-30 AT AT08108/68A patent/AT287002B/de not_active IP Right Cessation
- 1966-11-30 CH CH958369A patent/CH560681A5/xx not_active IP Right Cessation
- 1966-11-30 AT AT810968A patent/AT273998B/de active
- 1966-11-30 CH CH958269A patent/CH575386A5/xx not_active IP Right Cessation
- 1966-11-30 AT AT1109466A patent/AT273989B/de active
- 1966-11-30 CH CH1711066A patent/CH548380A/xx not_active IP Right Cessation
- 1966-11-30 AT AT810768A patent/AT273997B/de active
- 1966-12-01 SE SE16446/66A patent/SE329608B/xx unknown
- 1966-12-01 FR FR85764A patent/FR1510941A/fr not_active Expired
- 1966-12-01 GB GB53773/66A patent/GB1171935A/en not_active Expired
- 1966-12-02 MC MC661A patent/MC633A1/xx unknown
- 1966-12-02 BR BR185071/66A patent/BR6685071D0/pt unknown
- 1966-12-02 NO NO165846A patent/NO123645B/no unknown
- 1966-12-02 BE BE690604D patent/BE690604A/xx unknown
- 1966-12-02 OA OA52677A patent/OA02281A/xx unknown
-
1967
- 1967-02-28 FR FR96766A patent/FR6272M/fr not_active Expired
-
1968
- 1968-01-27 ES ES349857A patent/ES349857A1/es not_active Expired
-
1970
- 1970-11-24 CY CY56670A patent/CY566A/xx unknown
-
1971
- 1971-12-31 MY MY197158A patent/MY7100058A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR6272M (en, 2012) | 1968-08-26 |
| FI45961C (fi) | 1972-11-10 |
| MC633A1 (fr) | 1967-10-17 |
| AT273998B (de) | 1969-09-10 |
| GB1171935A (en) | 1969-11-26 |
| LU52465A1 (en, 2012) | 1968-06-25 |
| FI45961B (en, 2012) | 1972-07-31 |
| BR6685071D0 (pt) | 1973-12-04 |
| DE1518895A1 (de) | 1969-07-10 |
| OA02281A (fr) | 1970-05-05 |
| CH560681A5 (en, 2012) | 1975-04-15 |
| CY566A (en) | 1970-11-24 |
| ES349857A1 (es) | 1969-11-01 |
| MY7100058A (en) | 1971-12-31 |
| AT273997B (de) | 1969-09-10 |
| DK120895B (da) | 1971-08-02 |
| IL26927A (en) | 1972-03-28 |
| CH575386A5 (en, 2012) | 1976-05-14 |
| AT287002B (de) | 1971-01-11 |
| IS1612A7 (is) | 1967-05-25 |
| CH548380A (de) | 1974-04-30 |
| SE329608B (en, 2012) | 1970-10-19 |
| AT273989B (de) | 1969-09-10 |
| BE690604A (en, 2012) | 1967-06-02 |
| DE1518895B2 (de) | 1978-03-30 |
| US3621057A (en) | 1971-11-16 |
| FR1510941A (fr) | 1968-01-26 |
| DE1518895C3 (de) | 1978-12-07 |
| NL6616441A (en, 2012) | 1967-06-05 |
| NO123645B (en, 2012) | 1971-12-27 |
| IS809B6 (is) | 1972-05-02 |
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