ES330705A1 - Procedure for the preparation of new substitute ariloxy-2-hydroxy-3-aminopropanes (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of new substitute ariloxy-2-hydroxy-3-aminopropanes (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES330705A1 ES330705A1 ES0330705A ES330705A ES330705A1 ES 330705 A1 ES330705 A1 ES 330705A1 ES 0330705 A ES0330705 A ES 0330705A ES 330705 A ES330705 A ES 330705A ES 330705 A1 ES330705 A1 ES 330705A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- general formula
- see formula
- tert
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Procedure for the preparation of new racemic or optically active substituted 1-aryloxy-2-hydroxy-3-amino-propanes, of the general formula **(See formula)** where n is the number 1 or 2, and R1 means the isopropyl or tert-butyl groups, R2 is hydrogen, halogen, or methyl, R3 and R4 (which may be the same or different) mean hydrogen or methyl, with the proviso that that at least one of the R2-R4 residues is different from hydrogen, as well as from its addition salts with physiologically tolerable acids, characterized in that an epoxide of the general formula **(See formula)** wherein R2-R4 and n have the aforementioned significance, are reacted with isopropylamine or tert-butylamine, or by a halogenated compound of the formula **(See formula)** wherein R2-R4 and n have the aforementioned significance and Hal signifies a halogen atom, is reacted with isopropylamine or tert-butylamine, or by an oxazolidone of the general formula **(See formula)** where R1-R4 have the aforementioned significance, it hydrolyzes with alkalysis, or because a tertiary amine of the general formula **(See formula)** Where n and R1-R4 have the aforementioned significance, it is subjected to hydrogenolysis, and because, eventually, the racemates obtained are split according to usual methods into their optically active components and because, eventually, the obtained compounds are transformed into their salts. addition with physiologically tolerable acids. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3734765 | 1965-09-01 | ||
| DEB0085392 | 1966-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES330705A1 true ES330705A1 (en) | 1967-10-01 |
Family
ID=25967792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0330705A Expired ES330705A1 (en) | 1965-09-01 | 1966-08-29 | Procedure for the preparation of new substitute ariloxy-2-hydroxy-3-aminopropanes (Machine-translation by Google Translate, not legally binding) |
Country Status (6)
| Country | Link |
|---|---|
| BE (3) | BE686313A (en) |
| CH (4) | CH470346A (en) |
| ES (1) | ES330705A1 (en) |
| FR (1) | FR6403M (en) |
| GB (1) | GB1160448A (en) |
| NL (2) | NL6612340A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3856818A (en) * | 1972-07-03 | 1974-12-24 | Squibb & Sons Inc | Tricyclic phenoxy aminopropanols |
| EP0003664B1 (en) * | 1978-02-08 | 1982-02-17 | Imperial Chemical Industries Plc | Alkanolamine derivatives, process for their preparation and pharmaceutical compositions containing them |
| FR2507181A1 (en) | 1981-06-05 | 1982-12-10 | Sanofi Sa | NOVEL ETHERS OF PHENOL ACTIVE ON THE CARDIOVASCULAR SYSTEM, PROCESS FOR PREPARING THEM AND USE THEREOF IN MEDICAMENTS |
-
1966
- 1966-08-29 ES ES0330705A patent/ES330705A1/en not_active Expired
- 1966-09-01 CH CH1269566A patent/CH470346A/en not_active IP Right Cessation
- 1966-09-01 GB GB39170/66A patent/GB1160448A/en not_active Expired
- 1966-09-01 CH CH119669A patent/CH471076A/en not_active IP Right Cessation
- 1966-09-01 CH CH119869A patent/CH470347A/en not_active IP Right Cessation
- 1966-09-01 BE BE686313D patent/BE686313A/xx unknown
- 1966-09-01 BE BE686312D patent/BE686312A/xx unknown
- 1966-09-01 CH CH119769A patent/CH471077A/en not_active IP Right Cessation
- 1966-09-01 NL NL6612340A patent/NL6612340A/xx unknown
- 1966-09-01 NL NL6612374A patent/NL6612374A/xx unknown
- 1966-09-01 BE BE686311D patent/BE686311A/xx unknown
- 1966-11-30 FR FR85635A patent/FR6403M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1160448A (en) | 1969-08-06 |
| FR6403M (en) | 1968-10-21 |
| BE686311A (en) | 1967-03-01 |
| BE686312A (en) | 1967-03-01 |
| CH471076A (en) | 1969-04-15 |
| CH470346A (en) | 1969-03-31 |
| CH470347A (en) | 1969-03-31 |
| NL6612374A (en) | 1967-03-02 |
| BE686313A (en) | 1967-03-01 |
| CH471077A (en) | 1969-04-15 |
| NL6612340A (en) | 1967-03-02 |
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