ES329218A1 - Un procedimiento para la preparacion de derivados de tetrahidro-isoquinolina. - Google Patents
Un procedimiento para la preparacion de derivados de tetrahidro-isoquinolina.Info
- Publication number
- ES329218A1 ES329218A1 ES0329218A ES329218A ES329218A1 ES 329218 A1 ES329218 A1 ES 329218A1 ES 0329218 A ES0329218 A ES 0329218A ES 329218 A ES329218 A ES 329218A ES 329218 A1 ES329218 A1 ES 329218A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- lower alkyl
- acid addition
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003526 tetrahydroisoquinolines Chemical class 0.000 title 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- -1 hydroxymethylene group Chemical group 0.000 abstract 2
- 238000006683 Mannich reaction Methods 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 125000003039 tetrahydroisoquinolinyl group Chemical class C1(NCCC2=CC=CC=C12)* 0.000 abstract 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB30549/65A GB1079520A (en) | 1965-07-19 | 1965-07-19 | Novel tetrahydro-isoquinoline derivatives and a process for the manufacture thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES329218A1 true ES329218A1 (es) | 1967-08-16 |
Family
ID=10309382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0329218A Expired ES329218A1 (es) | 1965-07-19 | 1966-07-16 | Un procedimiento para la preparacion de derivados de tetrahidro-isoquinolina. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3450704A (en)) |
| BE (1) | BE684185A (en)) |
| BR (1) | BR6681255D0 (en)) |
| CH (1) | CH464922A (en)) |
| DE (1) | DE1695147A1 (en)) |
| DK (1) | DK117704B (en)) |
| ES (1) | ES329218A1 (en)) |
| FR (1) | FR5796M (en)) |
| GB (1) | GB1079520A (en)) |
| IL (1) | IL26040A (en)) |
| NL (1) | NL6610093A (en)) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3903091A (en) * | 1970-02-06 | 1975-09-02 | Sumitomo Chemical Co | 1,2,3,4-Tetrahydroisoquinoline derivatives |
| CA2651732C (en) * | 2006-05-18 | 2014-10-14 | Mannkind Corporation | Intracellular kinase inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT190517B (de) * | 1954-06-22 | 1957-07-10 | Wander Ag Dr A | Verfahren zur Herstellung neuer, substituierter Tetrahydroisochinolinverbindungen |
| GB1032054A (en) * | 1963-07-19 | 1966-06-08 | Roche Products Ltd | Substituted isoquinoline and piperazine derivatives and a process for the manufacture thereof |
-
1965
- 1965-07-19 GB GB30549/65A patent/GB1079520A/en not_active Expired
-
1966
- 1966-06-24 CH CH919866A patent/CH464922A/de unknown
- 1966-06-27 IL IL26040A patent/IL26040A/en unknown
- 1966-06-28 DE DE19661695147 patent/DE1695147A1/de active Pending
- 1966-07-07 US US563396A patent/US3450704A/en not_active Expired - Lifetime
- 1966-07-13 BR BR181255/66A patent/BR6681255D0/pt unknown
- 1966-07-15 BE BE684185D patent/BE684185A/xx unknown
- 1966-07-16 ES ES0329218A patent/ES329218A1/es not_active Expired
- 1966-07-18 NL NL6610093A patent/NL6610093A/xx unknown
- 1966-07-19 FR FR69810A patent/FR5796M/fr not_active Expired
- 1966-07-19 DK DK373466AA patent/DK117704B/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1695147A1 (de) | 1970-12-17 |
| CH464922A (de) | 1968-11-15 |
| IL26040A (en) | 1970-04-20 |
| NL6610093A (en)) | 1967-01-20 |
| DK117704B (da) | 1970-05-25 |
| BR6681255D0 (pt) | 1973-12-26 |
| FR5796M (en)) | 1968-02-12 |
| GB1079520A (en) | 1967-08-16 |
| BE684185A (en)) | 1967-01-16 |
| US3450704A (en) | 1969-06-17 |
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