ES328088A1 - A procedure to prepare mucolytic agents. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure to prepare mucolytic agents. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES328088A1 ES328088A1 ES0328088A ES328088A ES328088A1 ES 328088 A1 ES328088 A1 ES 328088A1 ES 0328088 A ES0328088 A ES 0328088A ES 328088 A ES328088 A ES 328088A ES 328088 A1 ES328088 A1 ES 328088A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- hydrogen
- carbon atoms
- translation
- machine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A process for preparing a compound having the formula: ** (See formula) ** wherein R1 and R2 are hydrogen or an alkyl group of up to 4 carbon atoms; R3 is hydrogen, an alkyl, aralkyl, or aryl group, each of up to 9 carbon atoms; N is piperidino, pyrrolidino, N'-R5 -piperazino, morpholino, thiamorpholino, hexamethyleneimino, or amino, wherein R4 is hydrogen, alkyl, alkenyl, cycloalkyl, or cycloalkenyl, each of up to 5 carbon atoms, and they are unsubstituted or substituted by up to two hydroxyl groups; R5 is hydrogen or a lower alkyl group of up to 4 carbon atoms, and is unsubstituted or substituted by two hydroxyl groups; characterized by reacting cysteine or a substitution product thereof, which has the formula: ** (See formula) ** wherein Q is hydrogen or an easily separable protecting group, Y is hydrogen or an alkyl group, and R1, R2 and R3 are as defined above; with an amide of the formula R 4 R 5 NH, wherein R 4 and R 5 are as defined above, and with an acylating agent having at least one constituent radical of the formula R 3 CO-; the reaction with the amine and the acylating agent occurring in any sequence; and separating the protecting group when present; or reducing a bis-N-acylcysteine of the formula: ** (See formula) ** to the desired N-acylcysteine. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US467674A US3340147A (en) | 1965-06-28 | 1965-06-28 | Amides of n-acylated cysteines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES328088A1 true ES328088A1 (en) | 1967-08-01 |
Family
ID=59256495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0328088A Expired ES328088A1 (en) | 1965-06-28 | 1966-06-18 | A procedure to prepare mucolytic agents. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES328088A1 (en) |
-
1966
- 1966-06-18 ES ES0328088A patent/ES328088A1/en not_active Expired
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