ES327925A1 - Un procedimiento para la produccion de derivados hidrogenados de tebaina y oripavina. - Google Patents
Un procedimiento para la produccion de derivados hidrogenados de tebaina y oripavina.Info
- Publication number
- ES327925A1 ES327925A1 ES0327925A ES327925A ES327925A1 ES 327925 A1 ES327925 A1 ES 327925A1 ES 0327925 A ES0327925 A ES 0327925A ES 327925 A ES327925 A ES 327925A ES 327925 A1 ES327925 A1 ES 327925A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- carbon atoms
- hydrogen atom
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 230000001476 alcoholic effect Effects 0.000 abstract 2
- 125000002723 alicyclic group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- -1 nicotinyl Chemical group 0.000 abstract 2
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- ZKLXUUYLEHCAMF-UUWFMWQGSA-N Oripavine Chemical class C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(O)C5=C4[C@@]21[C@H]3O5 ZKLXUUYLEHCAMF-UUWFMWQGSA-N 0.000 abstract 1
- ZKLXUUYLEHCAMF-UHFFFAOYSA-N Oripavine Chemical class COC1=CC=C2C(N(CC3)C)CC4=CC=C(O)C5=C4C23C1O5 ZKLXUUYLEHCAMF-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 125000002524 organometallic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical class C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB25289/65A GB1136214A (en) | 1965-06-15 | 1965-06-15 | Thebaine and oripavine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES327925A1 true ES327925A1 (es) | 1967-04-01 |
Family
ID=10225305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0327925A Expired ES327925A1 (es) | 1965-06-15 | 1966-06-14 | Un procedimiento para la produccion de derivados hidrogenados de tebaina y oripavina. |
Country Status (14)
| Country | Link |
|---|---|
| AT (1) | AT272530B (cs) |
| BE (1) | BE682551A (cs) |
| BR (1) | BR6680359D0 (cs) |
| CH (1) | CH558362A (cs) |
| DE (1) | DE1620206A1 (cs) |
| DK (1) | DK115926B (cs) |
| ES (1) | ES327925A1 (cs) |
| FI (1) | FI49724C (cs) |
| FR (1) | FR6395M (cs) |
| GB (1) | GB1136214A (cs) |
| LU (1) | LU51306A1 (cs) |
| NL (1) | NL6608255A (cs) |
| NO (1) | NO119590B (cs) |
| SE (1) | SE325276B (cs) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2554816B1 (fr) * | 1983-11-16 | 1986-09-26 | Sanofi Sa | Nouveau derive de la nororipavine presentant a la fois une activite agoniste et antagoniste des recepteurs morphiniques |
| KR100204659B1 (ko) * | 1996-05-28 | 1999-06-15 | 강재헌 | 신규한 부프레노핀계 진통제용 화합물 |
| RU2138502C1 (ru) * | 1999-03-29 | 1999-09-27 | Закрытое акционерное общество "РМА-Фарм" | Способ получения 17-циклопропилметил-6,14-эндо-этано-7-(2-гидрокси-3,3-диметилбут-2-ил)тетр агидро-17-норорипавина |
| AUPQ968300A0 (en) | 2000-08-25 | 2000-09-21 | Glaxo Wellcome Australia Ltd | Chemical methods |
| GB2388369B (en) | 2002-05-10 | 2004-05-05 | Reckitt Benckiser Healthcare | Demethylation of thebaine derivative |
| GB0421687D0 (en) † | 2004-09-30 | 2004-11-03 | Johnson Matthey Plc | Preparation of opiate analgesics |
| US8703099B2 (en) | 2005-02-24 | 2014-04-22 | Dr Pharma Nova, Llc | Registry method and control system for DEA schedule II-V medicines |
| DE102006054731B4 (de) | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| AU2009277095B2 (en) * | 2008-07-30 | 2012-09-06 | Purdue Pharma L.P. | Buprenorphine analogs |
| US8293906B2 (en) | 2008-09-30 | 2012-10-23 | Mallinckrodt Llc | Processes for the alkylation of norbuprenorphine with reduced impurity formation |
| MX2011011245A (es) | 2009-04-24 | 2012-04-11 | Univ Brock | Proceso para la preparacion de compuestos de morfinano. |
| GB201111775D0 (en) | 2011-07-08 | 2011-08-24 | Univ Bath | Compounds and uses thereof |
| US20140363487A1 (en) | 2011-12-12 | 2014-12-11 | Purdue Pharma L.P. | Transdermal delivery system comprising buprenorphine |
| RS61377B1 (sr) | 2012-07-26 | 2021-02-26 | Camurus Ab | Opioidne formulacije |
| HUE053273T2 (hu) | 2012-07-26 | 2021-06-28 | Camurus Ab | Opioid készítmények |
| WO2014087226A1 (en) * | 2012-12-07 | 2014-06-12 | Purdue Pharma L.P. | Buprenorphine analogs as opiod receptor modulators |
| DE112014002664T5 (de) | 2013-06-04 | 2016-04-07 | Lts Lohmann Therapie-Systeme Ag | Transdermales Verabreichungssystem |
| CA3238849A1 (en) | 2021-12-16 | 2023-06-22 | Arevipharma Gmbh | Method of making buprenorphine and precursor compounds thereof |
-
1965
- 1965-06-15 GB GB25289/65A patent/GB1136214A/en not_active Expired
-
1966
- 1966-06-10 NO NO163395A patent/NO119590B/no unknown
- 1966-06-13 LU LU51306A patent/LU51306A1/xx unknown
- 1966-06-13 FI FI661555A patent/FI49724C/fi active
- 1966-06-14 ES ES0327925A patent/ES327925A1/es not_active Expired
- 1966-06-14 BR BR180359/66A patent/BR6680359D0/pt unknown
- 1966-06-14 NL NL6608255A patent/NL6608255A/xx unknown
- 1966-06-14 SE SE08101/66A patent/SE325276B/xx unknown
- 1966-06-15 DE DE19661620206 patent/DE1620206A1/de active Pending
- 1966-06-15 CH CH861766A patent/CH558362A/de not_active IP Right Cessation
- 1966-06-15 FR FR65560A patent/FR6395M/fr not_active Expired
- 1966-06-15 BE BE682551D patent/BE682551A/xx not_active IP Right Cessation
- 1966-06-15 DK DK307766AA patent/DK115926B/da unknown
- 1966-06-15 AT AT571566A patent/AT272530B/de active
Also Published As
| Publication number | Publication date |
|---|---|
| NO119590B (cs) | 1970-06-08 |
| DK115926B (da) | 1969-11-24 |
| GB1136214A (en) | 1968-12-11 |
| DE1620206A1 (de) | 1970-03-19 |
| FI49724C (fi) | 1975-09-10 |
| SE325276B (cs) | 1970-06-29 |
| BR6680359D0 (pt) | 1973-12-26 |
| BE682551A (cs) | 1966-11-14 |
| NL6608255A (cs) | 1966-12-16 |
| AT272530B (de) | 1969-07-10 |
| FI49724B (cs) | 1975-06-02 |
| CH558362A (de) | 1975-01-31 |
| LU51306A1 (cs) | 1966-08-16 |
| FR6395M (cs) | 1968-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19870112 |