ES321631A1 - Procedure for the preparation of 5,6-dihydro-6-oxormorphantridines 5-basically replaced. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of 5,6-dihydro-6-oxormorphantridines 5-basically replaced. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES321631A1 ES321631A1 ES0321631A ES321631A ES321631A1 ES 321631 A1 ES321631 A1 ES 321631A1 ES 0321631 A ES0321631 A ES 0321631A ES 321631 A ES321631 A ES 321631A ES 321631 A1 ES321631 A1 ES 321631A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- lower alkyl
- hydrogen
- dihydro
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Process for the preparation of 5-basicly substituted 5,6-dihydro-6-oxomorfantridines of the formula: ** (See formula) ** wherein R means a straight or branched alkylene group with 2 to 4 C atoms; R1 and R2 are the same or different and mean hydrogen or lower alkyl, one of both R3 being hydrogen, and the other halogen or lower alkyl, and R4 represents a lower alkyl moiety, as well as acid addition salts thereof, characterized by that either: a) Amines of the formula XH are reacted, optionally after the preceding or simultaneous action of a condensation medium, with reactable esters of alcohols of the formula YR-OH, with X and Y being interchangeable with each other, and, on the one hand, they represent a residue of 11-R4-5,6-dihydro-6-oxo-5-morfantridinyl, halogenated in one of both nuclei of benzol or inferiorly alkylated, on the other hand, the basic rest (see formula), while R, R1, R2 and R4 have the meaning quoted above, or because b) They are cyclized, with the release of water, respectively of an alcohol, an acid or an ester, o-amino-o'-carboxy (respectively, carbalkoxy) -1,1-diphenylalkanes n-aminoalkylated of the formula: ** (See formula) ** wherein R, R1, R2, R3 and R4 have the meaning indicated above, meaning R5 hydrogen or an acyl group, and R6 hydrogen or a lower alkyl group, or because c) For the preparation of compounds according to formula I, in which R 1 and/or R 2 represent lower alkyl, primary or secondary secondary amines of the formula are ** (See formula) ** wherein R, R1, R3 and R4 have the meaning indicated above, after which the reaction product is isolated in the form of the free base or of an acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH32765A CH464930A (en) | 1965-01-11 | 1965-01-11 | Process for the preparation of 5-basic substituted 5,6-dihydro-6-oxomorphanthridines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES321631A1 true ES321631A1 (en) | 1966-09-01 |
Family
ID=4184485
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES0321631A Expired ES321631A1 (en) | 1965-01-11 | 1966-01-11 | Procedure for the preparation of 5,6-dihydro-6-oxormorphantridines 5-basically replaced. (Machine-translation by Google Translate, not legally binding) |
Country Status (9)
Country | Link |
---|---|
AT (3) | AT260270B (en) |
BE (1) | BE674950A (en) |
BR (1) | BR6676352D0 (en) |
CH (1) | CH464930A (en) |
DE (1) | DE1620722A1 (en) |
ES (1) | ES321631A1 (en) |
FR (1) | FR5915M (en) |
GB (1) | GB1078266A (en) |
IL (1) | IL24925A (en) |
-
1965
- 1965-01-11 CH CH32765A patent/CH464930A/en unknown
-
1966
- 1966-01-03 AT AT221667A patent/AT260270B/en active
- 1966-01-03 AT AT2466A patent/AT260259B/en active
- 1966-01-03 AT AT221567A patent/AT260269B/en active
- 1966-01-05 IL IL2492566A patent/IL24925A/en unknown
- 1966-01-05 GB GB5226466A patent/GB1078266A/en not_active Expired
- 1966-01-05 DE DE19661620722 patent/DE1620722A1/en active Pending
- 1966-01-11 BE BE674950D patent/BE674950A/xx unknown
- 1966-01-11 ES ES0321631A patent/ES321631A1/en not_active Expired
- 1966-01-11 FR FR45424A patent/FR5915M/fr not_active Expired
- 1966-01-11 BR BR17635266A patent/BR6676352D0/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL24925A (en) | 1969-04-30 |
AT260259B (en) | 1968-02-26 |
AT260269B (en) | 1968-02-26 |
GB1078266A (en) | 1967-08-09 |
CH464930A (en) | 1968-11-15 |
BR6676352D0 (en) | 1973-09-06 |
DE1620722A1 (en) | 1970-08-27 |
AT260270B (en) | 1968-02-26 |
FR5915M (en) | 1968-04-01 |
BE674950A (en) | 1966-07-11 |
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