ES320382A1 - Procedure for the obtaining of benzolsulfonilureas. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining benzolsulfonylureas of the formula ** (See formula) ** where they represent: Z oxygen or sulfur R hydrogen, lower alkyl or phenylalkyl, R1 a) alkyl or alkenyl with 2-8 carbon atoms, b) phenylalkyl lower c) cyclohexylalkyl lower, d) endoalkylenecyclohexyl, endoalkylenecyclohexenyl, endoalkylenecyclohexylmethyl or endoalkylenecyclohexenylmethyl with 1-2 carbon atoms in the endoalkylene, e) lower alkylcyclohexyl, lower alkoxycyclohexyl, f) cycloalkyl with 5-8 carbon atoms, g) cyclohexenyl, cyclohexenylmethyl, And a hydrocarbon chain with 1-4 carbon atoms, X and X1 each hydrogen, alkyl having 1 to 6 C atoms, the alkyl radicals being able, together with the nitrogen atom, to also form a saturated heterocyclic ring, cycloalkyl with 5-8 carbon atoms, cyclohexylalkyl, lower alkylcyclohexyl , phenyl, phenyl-lower alkyl, each time the phenyl radical may be substituted by lower alkyl, lower alkoxy, halogen, CF3 or NO2, which may be the same or different X and X ', as well as their salts, characterized by a) converting amines of the formula R1NH2, or optionally their salts, with benzolsulfonyl isocyanates, benzolsulfonylcarbamic acid esters, benzolsulfonylthiocarbamic acid esters, benzolsulfonylcarbamic acid halides or benzolsulfonyl ureas, which bear the substituent ** (See formula) ** b) transforming benzolsulfonamides bearing the substituent ** (See formula) ** or their salts with isocyanates, carbamic acid esters, thiocarbamic acid esters, carbamic acid halides or ureas, all bearing the R 1 substituent. c) transforming benzolsulfochlorides bearing the substituent ** (See formula) ** with ureas, isourea ethers, isothiourea ethers or parabanic acids, all substituted by R1, and hydrolyzed the benzolsulfonyl isourea ethers, benzolsulfonyl isothiourea ethers or benzenesulfonyl parabanic acids obtained by this or by another process, d) replacing the sulfur atom or the two sulfur atoms, in whole or in part, with oxygen atoms in corresponding benzolsulfonylthioureas. e) oxidizing correspondingly substituted benzolsulfenylureas or benzolsulfinylureas. f) enter benzolsulfenilureas of the formula ** (See formula) ** with one or several reaction phases the rest ** (See formula) ** and optionally treating the process products with alkaline media for the formation of salts. (Machine-translation by Google Translate, not legally binding)