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Sandoz AG
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Sandoz AG
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Priority claimed from CH1020163Aexternal-prioritypatent/CH424789A/en
Application filed by Sandoz AGfiledCriticalSandoz AG
Publication of ES307699A1publicationCriticalpatent/ES307699A1/en
C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
C—CHEMISTRY; METALLURGY
C07—ORGANIC CHEMISTRY
C07J—STEROIDS
C07J75/00—Processes for the preparation of steroids in general
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Chemical & Material Sciences
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Organic Chemistry
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Health & Medical Sciences
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General Health & Medical Sciences
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Steroid Compounds
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Cephalosporin Compounds
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
"Procedure for the production of heterocyclic compounds" of formula Ia, **(See formula)** wherein R1 signifies a (C2-C4) acyl radical, R2 signifies a hydrogen atom or a (C1-C4) phenyl or 1-methyl-4-piperidyl radical, R3 signifies a hydrogen atom or the hydroxyl radical and R4 means a hydrogen atom or the hydroxyl radical, characterized in that a cetal derivative of a compound of formula IIa is condensed, **(See formula)** in which R3 and R4 have the aforementioned meanings, with a compound of formula III, R2HN-NH2, in which R2 has the aforementioned meaning, the resulting aminopyrazole steroid is acylated in position 1', provided that any free hydroxyl radical present at position 21 is also acylated, the resulting acetamidopyrazole steroid is treated with a dilute organic or inorganic acid to remove the cephalic group and, should a free hydroxyl radical result at position 21, it is reacted with an acylating agent (C2-C4) to acylate at said position 21. (Machine-translation by Google Translate, not legally binding)
ES0307699A1963-08-191964-12-30Procedure for the production of heterociclic compounds. (Machine-translation by Google Translate, not legally binding)
ExpiredES307699A1
(en)