ES301905A1 - Pharmacologically active basic alcohols - Google Patents
Pharmacologically active basic alcoholsInfo
- Publication number
- ES301905A1 ES301905A1 ES0301905A ES301905A ES301905A1 ES 301905 A1 ES301905 A1 ES 301905A1 ES 0301905 A ES0301905 A ES 0301905A ES 301905 A ES301905 A ES 301905A ES 301905 A1 ES301905 A1 ES 301905A1
- Authority
- ES
- Spain
- Prior art keywords
- acid addition
- addition salt
- formula
- compounds
- carbon atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compounds of the general formula <FORM:1104292/C2/1> (wherein A and A1 are alkyl groups each having 2 or 3 carbon atoms, R1 is a hydrogen atom, R is a methyl or ethyl group and A, A1 and R have between them from 5 to 7 carbon atoms, or A and A1 are alkyl groups each having 1 to 3 carbon atoms and R and R1 are each a methyl group) and their acid addition salts are prepared by (a) catalytically hydrogenating an acid addition salt of a secondary ketoamine of the formula <FORM:1104292/C2/2> optionally followed by conversion to the free base or another acid addition salt, or (b)-in the case of compounds in which R1 is a hydrogen atom-reacting a primary amine of the formula <FORM:1104292/C2/3> with CH3COR and catalytically hydrogenating the product, optionally followed by conversion to an acid addition salt. The starting materials for process (a) may be prepared by reacting a haloketone of the formula <FORM:1104292/C2/4> (wherein X is a halogen atom) with RR1CH3CNH2 in the presence of a solvent and converting the product to an acid addition salt. The preparation of p-dipropoxybenzene, 2,5-dipropoxypropiophenone, 2,5 - dipropoxyisonitrosopropiophenone and racemic erythro - a - (2,5 - dipropoxyphenyl) - b - aminopropanol and its hydrochloride is described. The compounds of the invention have anti-arrhythmic activity, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB27613/63A GB1104292A (en) | 1963-07-11 | 1963-07-11 | Pharmacologically active basic alcohols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES301905A1 true ES301905A1 (en) | 1965-01-01 |
Family
ID=10262456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0301905A Expired ES301905A1 (en) | 1963-07-11 | 1964-07-10 | Pharmacologically active basic alcohols |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE650330A (en) |
| BR (1) | BR6460763D0 (en) |
| CH (2) | CH449653A (en) |
| DK (2) | DK111526B (en) |
| ES (1) | ES301905A1 (en) |
| FR (2) | FR1413914A (en) |
| GB (1) | GB1104292A (en) |
| NL (2) | NL6407885A (en) |
| SE (2) | SE318579B (en) |
-
0
- NL NL130977D patent/NL130977C/xx active
-
1963
- 1963-07-11 GB GB27613/63A patent/GB1104292A/en not_active Expired
-
1964
- 1964-01-11 BE BE650330A patent/BE650330A/xx unknown
- 1964-07-09 BR BR160763/64A patent/BR6460763D0/en unknown
- 1964-07-09 FR FR981303A patent/FR1413914A/en not_active Expired
- 1964-07-10 CH CH906764A patent/CH449653A/en unknown
- 1964-07-10 ES ES0301905A patent/ES301905A1/en not_active Expired
- 1964-07-10 DK DK346664AA patent/DK111526B/en unknown
- 1964-07-10 CH CH304467A patent/CH438369A/en unknown
- 1964-07-10 NL NL6407885A patent/NL6407885A/xx unknown
- 1964-07-13 SE SE8532/64A patent/SE318579B/xx unknown
- 1964-10-09 FR FR990979A patent/FR3741M/fr not_active Expired
-
1965
- 1965-07-03 DK DK341465AA patent/DK114842B/en unknown
-
1968
- 1968-03-15 SE SE03420/68A patent/SE328587B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL6407885A (en) | 1965-01-12 |
| GB1104292A (en) | 1968-02-21 |
| NL130977C (en) | |
| DK111526B (en) | 1968-09-09 |
| SE328587B (en) | 1970-09-21 |
| BR6460763D0 (en) | 1973-09-20 |
| BE650330A (en) | 1964-01-11 |
| FR3741M (en) | 1965-12-06 |
| CH449653A (en) | 1968-01-15 |
| SE318579B (en) | 1969-12-15 |
| DE1518444A1 (en) | 1969-08-07 |
| CH438369A (en) | 1967-06-30 |
| FR1413914A (en) | 1965-10-15 |
| DK114842B (en) | 1969-08-11 |
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