ES301517A1 - A procedure for the manufacture of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the manufacture of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES301517A1 ES301517A1 ES0301517A ES301517A ES301517A1 ES 301517 A1 ES301517 A1 ES 301517A1 ES 0301517 A ES0301517 A ES 0301517A ES 301517 A ES301517 A ES 301517A ES 301517 A1 ES301517 A1 ES 301517A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- lower alkyl
- phenyl
- hydrogen
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A process for the manufacture of benzodiazepine derivatives, characterized in that it consists of reacting a compound of the general formula ** (See formula) ** where B represents a carbonyl or methylene group, R1 and R2 represent hydrogen, halogen, trifluoromethyl, nitro, lower alkyl, amino or cyano R3 represents pyridyl, phenyl or phenyl monosubstituted with halogen, trifluoromethyl, nitro, lower alkyl, amino or cyano R4 represents hydrogen, lower alkyl, lower acyl or the group (see formula), R5 represents hydrogen or R4 and R5, taken together, represent an additional C-N bond, in which case the nitrogen atom in the 4-position can carry an oxygen atom, R7 represents a lower alkylene group, R8 represents lower alkyl, lower alkoxy, phenyl or the group (see formula), R9 and R10 represent hydrogen, lower alkyl, lower alkenyl or phenyl and R11 represents hydrogen or lower alkyl, preferably after carrying out before the conversion of said compound into its 1-sodium derivative, with a compound of the general formula X-R7-CO-R8 where R7 represents a lower alkylene group, R8 represents lower alkyl, lower alkyloxy, phenyl or the group (see formula), R9 and R10 represent hydrogen, lower alkyl, lower alkenyl or phenyl and X represents chlorine, bromine or iodine, subjecting, if desired, the obtained compound to one or more of the reaction steps taken from: (a) reducing a 4-oxide obtained, either catalytically in the presence of Raney nickel, or with a phosphoric trihalide; (b) reducing a 4,5-unsaturated compound obtained, by means of hydrogen in the presence of a platinum oxide catalyst; (c) alkylating or acylating a obtained compound carrying a hydrogen atom in the 4-position; (d) quaternizing a 4,5-unsaturated compound obtained and reducing the quaternized compound, by means of a borohydride; (e) reducing the nitro groups to amino groups; (f) converting the amino groups into halogens or cyano groups; (g) treating a 4-oxide which is unsubstituted in the 3-position with an anhydride of a lower alkanoic acid; (h) saponifying the compound thus obtained; e (i) convert a product obtained into its salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29125663A | 1963-06-28 | 1963-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES301517A1 true ES301517A1 (en) | 1965-02-01 |
Family
ID=23119568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0301517A Expired ES301517A1 (en) | 1963-06-28 | 1964-06-27 | A procedure for the manufacture of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE649717A (en) |
| BR (1) | BR6460322D0 (en) |
| CH (1) | CH461515A (en) |
| DE (1) | DE1445898A1 (en) |
| DK (1) | DK107030C (en) |
| ES (1) | ES301517A1 (en) |
| FR (2) | FR3825M (en) |
| GB (1) | GB1058427A (en) |
| NL (2) | NL6407307A (en) |
| SE (5) | SE317680B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU187262B (en) * | 1979-08-16 | 1985-12-28 | Richter Gedeon Vegyeszet | Process for preparing new tetrahydro-1,4-benzodiazepin-2-ones |
-
0
- NL NL131197D patent/NL131197C/xx active
-
1964
- 1964-06-15 CH CH779564A patent/CH461515A/en unknown
- 1964-06-22 FR FR979086A patent/FR3825M/fr active Active
- 1964-06-24 BR BR160322/64A patent/BR6460322D0/en unknown
- 1964-06-25 BE BE649717D patent/BE649717A/xx unknown
- 1964-06-26 NL NL6407307A patent/NL6407307A/xx unknown
- 1964-06-26 GB GB26490/64A patent/GB1058427A/en not_active Expired
- 1964-06-26 SE SE7810/64A patent/SE317680B/xx unknown
- 1964-06-26 SE SE2379/69A patent/SE342631B/xx unknown
- 1964-06-27 ES ES0301517A patent/ES301517A1/en not_active Expired
- 1964-06-27 FR FR979906A patent/FR1409329A/en not_active Expired
- 1964-06-29 DK DK325564AA patent/DK107030C/en active
-
1967
- 1967-06-29 SE SE9681/67A patent/SE321234B/xx unknown
- 1967-06-29 SE SE9682/67A patent/SE321235B/xx unknown
- 1967-06-29 SE SE09680/67A patent/SE334897B/xx unknown
-
1968
- 1968-06-18 DE DE19681445898 patent/DE1445898A1/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| SE342631B (en) | 1972-02-14 |
| SE321234B (en) | 1970-03-02 |
| SE334897B (en) | 1971-05-10 |
| DE1445898C3 (en) | 1974-10-10 |
| DE1445898A1 (en) | 1969-04-10 |
| FR3825M (en) | 1966-01-10 |
| DE1445898B2 (en) | 1974-02-21 |
| SE321235B (en) | 1970-03-02 |
| DK107030C (en) | 1967-04-17 |
| NL131197C (en) | |
| NL6407307A (en) | 1964-12-29 |
| GB1058427A (en) | 1967-02-08 |
| CH461515A (en) | 1968-08-31 |
| FR1409329A (en) | 1965-08-27 |
| BR6460322D0 (en) | 1973-09-20 |
| BE649717A (en) | 1964-12-28 |
| SE317680B (en) | 1969-11-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES309169A1 (en) | A procedure for the preparation of benzodiazepinic derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES301517A1 (en) | A procedure for the manufacture of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES385641A1 (en) | Benzodiazepine derivatives | |
| FR2216268A1 (en) | Catalytic hydrogenation of 6-methylenetetracyclines - using rhodium-tert phosphine complex catalyst giving a stereospecific prod. in high yield | |
| KR840007561A (en) | Method for preparing substituted tetrahydro naphthalene | |
| ES367956A1 (en) | Process for the preparation of 1,3-dihydro-2h-1,4-benzodiazepin-2-ones | |
| ES290968A1 (en) | Procedure for preparing a diol and its derivatives (Machine-translation by Google Translate, not legally binding) | |
| AT289032B (en) | Catalyst for the production of hydrogen from gases containing carbon monoxide and process for its production | |
| AT315269B (en) | Catalyst for the recombination of the hydrogen and oxygen gas produced during the operation of electric accumulators to water and process for the production of the catalyst | |
| GB824542A (en) | Method of producing n-alkyl-piperidine-alpha-monocarboxylic acid amides | |
| ES394761A1 (en) | 2-amino-1,5-benzodiazocine derivatives | |
| ES334299A1 (en) | Process for preparing therapeutically useful 3-substituted benzodiazepines | |
| ES309176A1 (en) | Procedure for the preparation of new amides of aryloxyacetic acid. (Machine-translation by Google Translate, not legally binding) | |
| ES391801A1 (en) | 1,1'-azo bis(1h-imidazo(1,2-a)pyridinium dibromide compounds | |
| ES404719A1 (en) | Process for the preparation of azines | |
| ES380407A1 (en) | Diacyloxy-benzoic acid anilides | |
| ES329218A1 (en) | A procedure for the preparation of tetrahydro-isoquinoline derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES396489A1 (en) | Benzodiazepine derivatives | |
| ES282834A1 (en) | Procedure for the manufacture of tricyclic compounds (Machine-translation by Google Translate, not legally binding) | |
| ES413244A1 (en) | A procedure for preparing benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES384932A1 (en) | Procedure for the preparation of derivatives of 5-nitrofurilicos. (Machine-translation by Google Translate, not legally binding) | |
| ES304314A1 (en) | Procedure for the obtaining of benzosulfonilureas. (Machine-translation by Google Translate, not legally binding) | |
| ES305413A1 (en) | A procedure for the preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) | |
| ES417337A2 (en) | Derivatives of phenylaminopyridine | |
| ES377921A1 (en) | Adamantylcarboxamidophenylacetic acid derivatives their preparation and compositions containing them |