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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of ES301516A1publicationCriticalpatent/ES301516A1/en
Priority claimed from CH800963Aexternal-prioritypatent/CH451120A/en
Application filed by F Hoffmann La Roche AGfiledCriticalF Hoffmann La Roche AG
Process for the preparation of tricyclic amines, of the general formula ** (See formula) ** where R represents hydrogen or an alkyl group, A represents an ethylenic radical, which may be substituted by lower alkyl radicals, B represents a secondary or tertiary amino group (one of the alkyl substituents of the ethylenic radical or the R group being bonded to an alkyl substituent of group B, with formation of an N-heterocycle), R1 represents hydrogen, halogen or an alkoxy or lower alkyl group, and Hal represents a halogen atom located at position 10 or 11, and salts of these compounds, characterized by dehydrating a compound of the general formula ** (See formula) ** where A, B, R, R1 and Hal have the meaning stated above and one of the symbols X and Y means hydrogen, while the other means hydroxyl, or else reacting a compound of the general formula ** (See formula) ** where A, R, R1 and Hal have the meaning stated above, and Z represents a halogen atom, with an amine of the formula H - B' (IV) where B 'represents the radical of a primary or secondary amine deprived of a hydrogen atom, or by adducing a primary or secondary amine of the formula H - B' (IV) where B 'has the same meaning as defined above, to a compound of the general formula ** (See formula) ** where R, R1 and Hal have the meaning stated above, Y D represents a vinyl group, which may be substituted by lower alkyl groups, and by converting, if desired, the secondary amines obtained in each case into tertiary amines and, if desired, transforming the obtained products into salts. (Machine-translation by Google Translate, not legally binding)
ES301516A1963-06-281964-06-27Procedure for the preparation of tricyclic amines (Machine-translation by Google Translate, not legally binding)
ExpiredES301516A1
(en)
Procedure for the preparation of new compounds of 1,4-benzodioxane and 1,5-benzodioxepane (Machine-translation by Google Translate, not legally binding)
A procedure for the preparation of derivatives of 1-amino- (replaced) -3-4'-0-5'-tiazol (replaced) -2-oxi-2-propanol. (Machine-translation by Google Translate, not legally binding)