ES3013568T3 - Substituted heteroaryl compounds useful as t cell activators - Google Patents
Substituted heteroaryl compounds useful as t cell activators Download PDFInfo
- Publication number
- ES3013568T3 ES3013568T3 ES20845305T ES20845305T ES3013568T3 ES 3013568 T3 ES3013568 T3 ES 3013568T3 ES 20845305 T ES20845305 T ES 20845305T ES 20845305 T ES20845305 T ES 20845305T ES 3013568 T3 ES3013568 T3 ES 3013568T3
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- ES
- Spain
- Prior art keywords
- oxo
- methyl
- carbonitrile
- dihydro
- dimethylpiperazin
- Prior art date
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- 125000001072 heteroaryl group Chemical group 0.000 title description 18
- 229940126530 T cell activator Drugs 0.000 title description 2
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- 230000000694 effects Effects 0.000 claims abstract description 19
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- 230000009385 viral infection Effects 0.000 claims abstract description 13
- 101710192015 Diacylglycerol kinase zeta Proteins 0.000 claims abstract description 7
- 101710181033 Diacylglycerol kinase alpha Proteins 0.000 claims abstract description 5
- 102100022735 Diacylglycerol kinase alpha Human genes 0.000 claims abstract description 5
- -1 benzo[d]oxazolyl Chemical group 0.000 claims description 73
- 239000000203 mixture Substances 0.000 claims description 47
- 239000003814 drug Substances 0.000 claims description 44
- 239000003937 drug carrier Substances 0.000 claims description 20
- 108010062677 Diacylglycerol Kinase Proteins 0.000 claims description 18
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- 102000011107 Diacylglycerol Kinase Human genes 0.000 claims description 12
- 201000001441 melanoma Diseases 0.000 claims description 11
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- ZOKCQQGCFOWFKN-JKSUJKDBSA-N 8-[(2S,5R)-4-[4-(4-fluorophenyl)-1,3-thiazol-2-yl]-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-1,5-naphthyridine-2-carbonitrile Chemical compound FC1=CC=C(C=C1)C=1N=C(SC=1)N1C[C@@H](N(C[C@H]1C)C1=CC(N(C=2C=CC(=NC1=2)C#N)C)=O)C ZOKCQQGCFOWFKN-JKSUJKDBSA-N 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- LUVVDHXVXFNOAP-UONOGXRCSA-N 8-[(2S,5R)-4-(6-fluoro-1,3-benzothiazol-2-yl)-2,5-dimethylpiperazin-1-yl]-5-methyl-6-oxo-1,5-naphthyridine-2-carbonitrile Chemical compound FC1=CC2=C(N=C(S2)N2C[C@@H](N(C[C@H]2C)C2=CC(N(C=3C=CC(=NC2=3)C#N)C)=O)C)C=C1 LUVVDHXVXFNOAP-UONOGXRCSA-N 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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| IN201911053558 | 2019-12-23 | ||
| PCT/US2020/066510 WO2021133752A1 (en) | 2019-12-23 | 2020-12-22 | Substituted heteroaryl compounds useful as t cell activators |
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| IL (1) | IL294273A (https=) |
| MX (1) | MX2022007372A (https=) |
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| LT4081305T (lt) | 2019-12-24 | 2024-11-25 | Carna Biosciences, Inc. | Diacilglicerolio kinazę moduliuojantys junginiai |
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| CA3222277A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
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| TW202315620A (zh) * | 2021-08-03 | 2023-04-16 | 英屬開曼群島商百濟神州有限公司 | 吡唑并吡啶酮化合物 |
| WO2023122777A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Oxime derivatives useful as t cell activators |
| WO2023122772A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Oxime derivatives useful as t cell activators |
| CN118451073A (zh) * | 2021-12-29 | 2024-08-06 | 百济神州有限公司 | 杂环化合物 |
| EP4472963A1 (en) * | 2022-02-01 | 2024-12-11 | Arvinas Operations, Inc. | Dgk targeting compounds and uses thereof |
| WO2023165525A1 (en) * | 2022-03-01 | 2023-09-07 | Insilico Medicine Ip Limited | Diacylglycerol kinase (dgk) alpha inhibitors and uses thereof |
| KR20240156394A (ko) | 2022-03-01 | 2024-10-29 | 인실리코 메디신 아이피 리미티드 | 디아실글리세롤 키나아제 (dgk) 알파 억제제 및 이의 용도 |
| JP2025510945A (ja) * | 2022-03-31 | 2025-04-15 | インベンティスバイオ カンパニー リミテッド | キナーゼ阻害剤、その製造方法および用途 |
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| US12600723B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| US12600722B2 (en) | 2022-07-18 | 2026-04-14 | Incyte Corporation | Tetracyclic compounds as DGK inhibitors |
| KR20250046310A (ko) * | 2022-08-09 | 2025-04-02 | 브리스톨-마이어스 스큅 컴퍼니 | T 세포 활성화제로서 유용한 3급 아민 치환된 비시클릭 화합물 |
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| ES2444574T3 (es) | 2006-09-19 | 2014-02-25 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa |
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| AR090263A1 (es) | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Terapia combinada de anticuerpos contra el csf-1r humano y las utilizaciones de la misma |
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| JP6464139B2 (ja) * | 2013-03-14 | 2019-02-06 | コンバージーン・リミテッド・ライアビリティ・カンパニーＣｏｎｖｅｒｇｅｎｅ Ｌｌｃ | ブロモドメイン含有タンパク質の阻害のための方法および組成物 |
| CN112654621B (zh) * | 2018-06-27 | 2024-05-14 | 百时美施贵宝公司 | 可作为t细胞活化剂的经取代萘啶酮化合物 |
| PT3814347T (pt) * | 2018-06-27 | 2023-07-18 | Bristol Myers Squibb Co | Compostos de naftiridinona úteis como ativadores de células t |
| JPWO2020071550A1 (ja) * | 2018-10-04 | 2021-09-24 | 京都薬品工業株式会社 | Ｃｄｋ８阻害剤およびその用途 |
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- 2020-12-22 IL IL294273A patent/IL294273A/en unknown
- 2020-12-22 CN CN202080089546.2A patent/CN114846015B/zh active Active
- 2020-12-22 US US17/785,585 patent/US20230086933A1/en active Pending
- 2020-12-22 WO PCT/US2020/066510 patent/WO2021133752A1/en not_active Ceased
- 2020-12-22 BR BR112022012204A patent/BR112022012204A2/pt not_active IP Right Cessation
- 2020-12-22 AU AU2020412472A patent/AU2020412472A1/en not_active Abandoned
- 2020-12-22 EP EP20845305.0A patent/EP4081524B1/en active Active
- 2020-12-22 MX MX2022007372A patent/MX2022007372A/es unknown
- 2020-12-22 KR KR1020227025312A patent/KR20220119458A/ko active Pending
- 2020-12-22 JP JP2022538813A patent/JP7677976B2/ja active Active
- 2020-12-22 CA CA3163003A patent/CA3163003A1/en active Pending
- 2020-12-22 ES ES20845305T patent/ES3013568T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4081524A1 (en) | 2022-11-02 |
| CN114846015A (zh) | 2022-08-02 |
| CN114846015B (zh) | 2024-07-30 |
| BR112022012204A2 (pt) | 2022-09-13 |
| AU2020412472A1 (en) | 2022-08-18 |
| US20230086933A1 (en) | 2023-03-23 |
| EP4081524B1 (en) | 2025-01-29 |
| JP7677976B2 (ja) | 2025-05-15 |
| WO2021133752A1 (en) | 2021-07-01 |
| JP2023508054A (ja) | 2023-02-28 |
| IL294273A (en) | 2022-08-01 |
| KR20220119458A (ko) | 2022-08-29 |
| MX2022007372A (es) | 2022-07-12 |
| CA3163003A1 (en) | 2021-07-01 |
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