ES3000984T3 - Polimorfos del compuesto antifúngico de triazol PC945 - Google Patents
Polimorfos del compuesto antifúngico de triazol PC945 Download PDFInfo
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- ES3000984T3 ES3000984T3 ES20824979T ES20824979T ES3000984T3 ES 3000984 T3 ES3000984 T3 ES 3000984T3 ES 20824979 T ES20824979 T ES 20824979T ES 20824979 T ES20824979 T ES 20824979T ES 3000984 T3 ES3000984 T3 ES 3000984T3
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- 238000011282 treatment Methods 0.000 claims description 24
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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Applications Claiming Priority (2)
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| GBGB1917867.2A GB201917867D0 (en) | 2019-12-06 | 2019-12-06 | Polymorphs |
| PCT/GB2020/053107 WO2021111142A1 (en) | 2019-12-06 | 2020-12-04 | Polymorphs of triazole antifungal compound pc945 |
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| ES3000984T3 true ES3000984T3 (es) | 2025-03-04 |
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| ES20824979T Active ES3000984T3 (es) | 2019-12-06 | 2020-12-04 | Polimorfos del compuesto antifúngico de triazol PC945 |
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| HU (1) | HUE069799T2 (https=) |
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| EP3227277B1 (en) | 2014-12-05 | 2020-02-05 | Pulmocide Limited | Antimycotic compound |
| CN117510488B (zh) * | 2022-07-28 | 2025-12-05 | 博瑞制药(苏州)有限公司 | 一种硫酸艾沙康唑的制备方法 |
| CN117330660A (zh) * | 2023-09-14 | 2024-01-02 | 广州医科大学附属第一医院（广州呼吸中心） | Uplc-ms/ms联用检测艾沙康唑的方法及应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1292472C (en) | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| DE3852477T2 (de) | 1987-11-20 | 1995-05-04 | Schering Corp | Tri- und tetrasubstituierte Oxetane und Tetrahydrofurane und deren Zwischenprodukte. |
| US5039676A (en) | 1990-05-11 | 1991-08-13 | Schering Corporation | Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof |
| US5714490A (en) | 1993-12-21 | 1998-02-03 | Schering Corporation | Tetrahydrofuran antifungals |
| PL181193B1 (pl) | 1993-12-21 | 2001-06-29 | Schering Corp | Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków |
| US5486625A (en) | 1994-07-08 | 1996-01-23 | Schering Corporation | Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents |
| HUP9701690A3 (en) | 1995-06-02 | 1998-04-28 | Schering Corp Kenilwort | Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same |
| EP0957101A1 (en) | 1998-05-14 | 1999-11-17 | Janssen Pharmaceutica N.V. | Water soluble azoles as broad-spectrum antifungals |
| EP1372394A1 (en) | 2001-04-03 | 2004-01-02 | Schering Corporation | Antifungal composition with enhanced bioavailability |
| EP2141159A1 (en) * | 2008-07-03 | 2010-01-06 | Sandoz AG | A Crystalline form of posaconazole |
| US9346791B2 (en) | 2011-09-07 | 2016-05-24 | The Johns Hopkins University | Itraconazole analogs and use thereof |
| EP3227277B1 (en) | 2014-12-05 | 2020-02-05 | Pulmocide Limited | Antimycotic compound |
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| SI4069690T1 (sl) | 2025-03-31 |
| BR112022006259A2 (pt) | 2022-06-21 |
| CO2022007808A2 (es) | 2022-06-30 |
| CN114746415B (zh) | 2025-04-11 |
| CN114746415A (zh) | 2022-07-12 |
| US12491182B2 (en) | 2025-12-09 |
| MX2022006654A (es) | 2022-09-07 |
| SA522432879B1 (ar) | 2025-01-26 |
| DK4069690T3 (da) | 2025-01-20 |
| EP4509179A2 (en) | 2025-02-19 |
| LT4069690T (lt) | 2025-01-10 |
| KR20220110726A (ko) | 2022-08-09 |
| SMT202400514T1 (it) | 2025-01-14 |
| PL4069690T3 (pl) | 2025-03-10 |
| GB201917867D0 (en) | 2020-01-22 |
| EP4509179A3 (en) | 2025-02-26 |
| EP4069690B1 (en) | 2024-11-13 |
| HUE069799T2 (hu) | 2025-04-28 |
| RS66401B1 (sr) | 2025-02-28 |
| US20260060980A1 (en) | 2026-03-05 |
| HRP20250042T1 (hr) | 2025-03-14 |
| EP4069690A1 (en) | 2022-10-12 |
| PT4069690T (pt) | 2024-12-13 |
| WO2021111142A1 (en) | 2021-06-10 |
| CA3155829A1 (en) | 2021-06-10 |
| JP2023505227A (ja) | 2023-02-08 |
| CL2022001464A1 (es) | 2023-03-24 |
| FI4069690T3 (fi) | 2025-01-21 |
| IL293401A (en) | 2022-07-01 |
| AU2020397613A1 (en) | 2022-06-02 |
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