ES2985805T3 - Ligandos de formación de imágenes de TAU y sus usos en el diagnóstico y el tratamiento de tauopatías - Google Patents
Ligandos de formación de imágenes de TAU y sus usos en el diagnóstico y el tratamiento de tauopatías Download PDFInfo
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- ES2985805T3 ES2985805T3 ES15818480T ES15818480T ES2985805T3 ES 2985805 T3 ES2985805 T3 ES 2985805T3 ES 15818480 T ES15818480 T ES 15818480T ES 15818480 T ES15818480 T ES 15818480T ES 2985805 T3 ES2985805 T3 ES 2985805T3
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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| PT3334761T (pt) * | 2015-08-13 | 2023-08-17 | Univ New York | Moléculas baseadas em anticorpo seletivo para o epítopo {p}ser404 da tau e os seus usos no diagnóstico e tratamento de tauopatias |
| JP6913078B2 (ja) | 2015-08-13 | 2021-08-04 | ニューヨーク・ユニバーシティ | タウの短縮型Ａｓｐ４２１エピトープに特異的な、抗体を基にした分子、ならびにタウ異常症の診断および治療におけるそれらの使用 |
| BR112018004916A2 (pt) | 2016-07-12 | 2018-12-11 | H Lundbeck As | anticorpos específicos para tau hiperfosforilada e métodos de uso dos mesmos |
| CA3036264A1 (en) * | 2016-09-08 | 2018-03-15 | Regenerative Research Foundation | Bi-functional anti-tau polypeptides and use thereof |
| US10364286B2 (en) * | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| US10995137B2 (en) | 2017-01-04 | 2021-05-04 | H. Lundbeck A/S | Antibodies specific for hyperphosphorlated tau for the treatment of ocular diseases |
| BR112019017021A2 (pt) | 2017-02-17 | 2020-04-14 | Denali Therapeutics Inc | anticorpos anti-tau e métodos de uso dos mesmos |
| CA3070446A1 (en) | 2017-07-25 | 2019-01-31 | Immutics, Inc. | Treating cancer by blocking the interaction of tim-3 and its ligand |
| CN109406469B (zh) * | 2018-10-24 | 2021-04-09 | 中国医科大学 | 基于蛋白结合诱导dna双链变构的检测色氨酸的方法 |
| US12365724B2 (en) * | 2018-12-10 | 2025-07-22 | New York University | Antibodies binding to phospho-tau comprising phosphorylated Ser396 and Ser404 and methods of detecting thereof |
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| CN1671416B (zh) | 2001-07-12 | 2013-01-02 | 杰斐逊·富特 | 超人源化抗体 |
| BRPI0610093A2 (pt) | 2005-05-05 | 2008-12-09 | Merck & Co Inc | composiÇço farmacÊutica, e, mÉtodo para prevenir ou tratar uma doenÇa associada com os depàsitos de amilàides de alfa-beta no cÉrebro de um paciente |
| WO2007059782A1 (en) | 2005-11-28 | 2007-05-31 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
| US8012936B2 (en) | 2006-03-29 | 2011-09-06 | New York University | Tau fragments for immunotherapy |
| WO2008140639A2 (en) | 2007-02-08 | 2008-11-20 | Oligomerix, Inc. | Biomarkers and assays for alzheimer's disease |
| HUE055739T2 (hu) | 2009-03-18 | 2021-12-28 | Ac Immune Sa | Eljárás terápiás alkalmazásra |
| UA107571C2 (xx) * | 2009-04-03 | 2015-01-26 | Фармацевтична композиція | |
| EP3329932A1 (en) | 2009-06-10 | 2018-06-06 | New York University | Immunological targeting of pathological tau proteins |
| RU2518291C2 (ru) | 2009-07-30 | 2014-06-10 | Пфайзер Вэксинс ЭлЭлСи | Антигенные tau-пептиды и их применения |
| AR092779A1 (es) * | 2011-10-07 | 2015-05-06 | Ac Immune Sa | Composicon farmaceutica que comprende anticuerpos que se unen a conformeros de proteinas tau |
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2015
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- 2015-07-06 JP JP2017500891A patent/JP6913018B2/ja active Active
- 2015-07-06 CN CN201580047108.9A patent/CN107073297B/zh active Active
- 2015-07-06 WO PCT/US2015/039205 patent/WO2016007414A1/en not_active Ceased
- 2015-07-06 US US15/324,141 patent/US10132818B2/en active Active
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2018
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2020
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| Publication number | Publication date |
|---|---|
| CN107073297B (zh) | 2021-09-14 |
| EP3166688A1 (en) | 2017-05-17 |
| US20190025331A1 (en) | 2019-01-24 |
| JP6913018B2 (ja) | 2021-08-04 |
| EP3166688C0 (en) | 2024-08-21 |
| US10132818B2 (en) | 2018-11-20 |
| US11519920B2 (en) | 2022-12-06 |
| CN107073297A (zh) | 2017-08-18 |
| JP2017532288A (ja) | 2017-11-02 |
| US20170212131A1 (en) | 2017-07-27 |
| US10859582B2 (en) | 2020-12-08 |
| EP3166688B1 (en) | 2024-08-21 |
| US20210055309A1 (en) | 2021-02-25 |
| EP3166688A4 (en) | 2017-12-20 |
| WO2016007414A1 (en) | 2016-01-14 |
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